Modulatory Effects of Stem Cells on Oxidative Stress and Antioxidant Defense System in Cancer

2022 ◽  
pp. 1-16
Author(s):  
Osama M. Ahmed ◽  
Noha A. Ahmed ◽  
Nour Y. S. Yassin ◽  
Eman R. Abd Elhaliem
Keyword(s):  
Oxidative Stress ◽  
Stem Cells ◽  
Antioxidant Defense ◽  
Antioxidant Defense System ◽  
Defense System

Skeletal muscle uncoupling-induced longevity in mice is linked to increased substrate metabolism and induction of the endogenous antioxidant defense system

2013 ◽  
Vol 304 (5) ◽  
pp. E495-E506 ◽  
Author(s):  
S. Keipert ◽  
M. Ost ◽  
A. Chadt ◽  
A. Voigt ◽  
V. Ayala ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Skeletal Muscle ◽  
Antioxidant Defense ◽  
Antioxidant Defense System ◽  
Mapk Signaling ◽  
Redox Signaling ◽  
Defense System ◽  
High Fat ◽  
Substrate Metabolism ◽  
Endogenous Antioxidant

Ectopic expression of uncoupling protein 1 (UCP1) in skeletal muscle (SM) mitochondria increases lifespan considerably in high-fat diet-fed UCP1 Tg mice compared with wild types (WT). To clarify the underlying mechanisms, we investigated substrate metabolism as well as oxidative stress damage and antioxidant defense in SM of low-fat- and high-fat-fed mice. Tg mice showed an increased protein expression of phosphorylated AMP-activated protein kinase, markers of lipid turnover (p-ACC, FAT/CD36), and an increased SM ex vivo fatty acid oxidation. Surprisingly, UCP1 Tg mice showed elevated lipid peroxidative protein modifications with no changes in glycoxidation or direct protein oxidation. This was paralleled by an induction of catalase and superoxide dismutase activity, an increased redox signaling (MAPK signaling pathway), and increased expression of stress-protective heat shock protein 25. We conclude that increased skeletal muscle mitochondrial uncoupling in vivo does not reduce the oxidative stress status in the muscle cell. Moreover, it increases lipid metabolism and reactive lipid-derived carbonyls. This stress induction in turn increases the endogenous antioxidant defense system and redox signaling. Altogether, our data argue for an adaptive role of reactive species as essential signaling molecules for health and longevity.

Impact of seasonally frozen soil on germinability and antioxidant enzyme activity of Picea asperata seeds

2009 ◽  
Vol 39 (4) ◽  
pp. 723-730 ◽  
Author(s):  
Jihong Qin ◽  
Qing Liu
Keyword(s):  
Oxidative Stress ◽  
Antioxidant Defense ◽  
Germination Rate ◽  
Antioxidant Defense System ◽  
Antioxidant Enzyme Activity ◽  
Frozen Soil ◽  
Defense System ◽  
Frozen Ground ◽  
Subalpine Zone ◽  
Picea Asperata

In the subalpine zone of the Qinghai–Tibetan Plateau of China, Dragon spruce (Picea asperata Mast.) is commonly used for reforestation. The aim of the present work was to study the effects of seasonally frozen soil on the germination of P. asperata seeds and to investigate whether these effects were associated with resumption of the antioxidant defense system. The nonfrozen treatment resulted in near failure of germination (1%) and was associated with relatively high levels of hydrogen peroxide (H2O2) and low activities of superoxide dismutase (SOD), catalase (CAT), and ascorbate peroxide (APX). Germination of P. asperata seeds at 10 cm under the seasonally frozen soil was higher than that at 5 cm by 26%; this higher germination rate was associated with the recovery of SOD, CAT, and APX activities. The levels of malondialdehyde (MDA) in seeds from seasonally frozen treatments were higher than those in the nonfrozen treatment, implying greater lipid peroxidation and that frozen seeds might have suffered from oxidative stress. The results indicate that seasonally frozen soil facilitated the germination of P. asperata seeds and that germination was closely related to the resumption of antioxidant enzymes activity. Overall, these findings suggest that the disappearance of seasonally frozen ground caused by global warming might result in failure of regeneration of P. asperata.

scholarly journals Biomarkers of oxidative stress and antioxidant defense system among Guatemalan preschool children attending daycare centers with a common menu offering (639.2)

2014 ◽  
Vol 28 (S1) ◽  
Author(s):  
María Soto‐Méndez ◽  
Concepción Aguilera ◽  
María Mesa ◽  
Laura Campaña‐Martín ◽  
Victoria Martín‐Laguna ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Preschool Children ◽  
Antioxidant Defense ◽  
Antioxidant Defense System ◽  
Defense System ◽  
Daycare Centers ◽  
Biomarkers Of Oxidative Stress

scholarly journals Effect of Daily Chewing Soft Buds and Leaves of Catha edulis (Khat) on the Antioxidant Defense System and Oxidative Stress Markers in Blood

2014 ◽  
Vol 40 (1) ◽  
pp. 1-6 ◽  
Author(s):  
Khalid Mohammed Naji ◽  
Maher Ali Al-Maqtari ◽  
Adnan Ali Al-Asbahi ◽  
Qais Yusuf M. Abdullah ◽  
R. Nagesh Babu ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Antioxidant Defense ◽  
Antioxidant Defense System ◽  
Oxidative Stress Markers ◽  
Defense System ◽  
Catha Edulis ◽  
Stress Markers ◽  
And Oxidative Stress

Ketamine-induced oxidative stress at different developmental stages of zebrafish (Danio rerio) embryos

RSC Advances ◽  
2016 ◽  
Vol 6 (66) ◽  
pp. 61254-61266 ◽  
Author(s):  
Luís M. Félix ◽  
Ana M. Vidal ◽  
Cindy Serafim ◽  
Ana M. Valentim ◽  
Luís M. Antunes ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Developmental Stage ◽  
Danio Rerio ◽  
Antioxidant Defense ◽  
Developmental Stages ◽  
Antioxidant Defense System ◽  
Defense System ◽  
Gradual Development ◽  
Energy Sensing ◽  
Danio Rerio Embryos

The changes induced by ketamine exposure were developmental stage-dependent, and related with the gradual development of the antioxidant defense system of the embryo, which is dependent on changes in energy-sensing pathways.

scholarly journals Oral Rg1 supplementation strengthens antioxidant defense system against exercise-induced oxidative stress in rat skeletal muscles

2012 ◽  
Vol 9 (1) ◽  
pp. 23 ◽  
Author(s):  
Szu-Hsien Yu ◽  
Hui-Yu Huang ◽  
Mallikarjuna Korivi ◽  
Ming-Fen Hsu ◽  
Chih-Yang Huang ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Skeletal Muscles ◽  
Antioxidant Defense ◽  
Antioxidant Defense System ◽  
Defense System ◽  
Exercise Induced
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