Complicated Ocular Trauma with Corneal Opacity

2021 ◽  
pp. 83-92
Author(s):  
Daniel Lani Louzada ◽  
Pedro Albuquerque Rebello ◽  
Guilherme Marge De Aquino Guedes ◽  
Juliana Herrera Sadala Mascato ◽  
Erick Araujo ◽  
...  
Keyword(s):  
Ocular Trauma ◽  
Corneal Opacity

scholarly journals Clinical Application of Foldable Capsular Vitreous Bodies in the Treatment of Severe Ocular Trauma and Silicone Oil Dependent Eyes

2021 ◽  
Author(s):  
Hao Jiang ◽  
Chao Xue ◽  
Yanlin Gao ◽  
Ying Chen ◽  
Yan Wang
Keyword(s):  
Visual Acuity ◽  
Clinical Application ◽  
Ocular Trauma ◽  
Silicone Oil ◽  
Anterior Segment ◽  
Vitreous Body ◽  
Corneal Opacity ◽  
Ultrasound Biomicroscopy ◽  
Significant Difference

Abstract Background: Recently, a new type of foldable capsular vitreous body (FCVB) has been developed for clinical application to fill the vitreous cavity with vitreous substitutes. It may be an ideal substitute for the vitreous body in eyes with severe retinal detachment. The aim of this study was to assess the application of a foldable capsular vitreous body (FCVB) in the treatment of severe ocular trauma and silicone oil (SO) dependent eyes.Methods: A retrospective analysis was performed on the clinical application of FCVB in the treatment of severe ocular trauma and SO dependent eyes. The results of best-corrected visual acuity and intraocular pressure (IOP) evaluation, B-scan ultrasonography or color Doppler ultrasonography, ultrasound biomicroscopy, and anterior segment photography were recorded during follow-up. A paired t-test was used to compare the difference in IOP before and after FCVB implantation. Results: Seven eyes of seven patients were included in the 6 months follow-up. In all cases, B-scan ultrasonography and ultrasound biomicroscopy showed that FCVB adapted closely to the globe wall and ciliary body, thus supporting the retina. Visual acuity did not improve, except in one case from LP to HM. The mean±SD IOP was 9.29±1.60mmHg prior to FCVB implantation and 10.43±0.98mmHg after implantation, with no significant difference between these measurements (P=0.066). Five of the seven patients developed differing degrees of corneal opacity and keratopathy. Conclusions: FCVB implantation may be a safe and effective method for the treatment of severe ocular trauma and SO dependent eyes. However, corneal opacity and keratopathy are potential serious complications after surgery. Appropriate case selection and proper surgical time require further investigation.

scholarly journals Wide-Field Landers Temporary Keratoprosthesis in Severe Ocular Trauma: Functional and Anatomical Results after One Year

2015 ◽  
Vol 2015 ◽  
pp. 1-6 ◽  
Author(s):  
Katarzyna Nowomiejska ◽  
Dariusz Haszcz ◽  
Cesare Forlini ◽  
Matteo Forlini ◽  
Joanna Moneta-Wielgos ◽  
...  
Keyword(s):  
Visual Acuity ◽  
Ocular Trauma ◽  
Silicone Oil ◽  
Corneal Opacity ◽  
Corneal Graft ◽  
Wide Field ◽  
Eye Trauma ◽  
Temporary Keratoprosthesis ◽  
One Year

Purpose. To evaluate longitudinal functional and anatomical results after combined pars plana vitrectomy (PPV) and penetrating keratoplasty (PKP) using a wide-field Landers intraoperative temporary keratoprosthesis (TKP) in patients with vitreoretinal pathology and corneal opacity due to severe ocular trauma.Material and Methods. Medical records of 12 patients who had undergone PPV/PKP/KP due to severe eye trauma were analyzed. Functional (best-corrected visual acuity) and anatomic outcomes (clarity of the corneal graft, retinal attachment, and intraocular pressure) were assessed during the follow-up (mean 16 months).Results. Final visual acuities varied from NLP to CF to 2 m. Visual acuity improved in 7 cases, was unchanged in 4 eyes, and worsened in 1 eye. The corneal graft was transparent during the follow-up in 3 cases and graft failure was observed in 9 eyes. Silicone oil was used as a tamponade in all cases and retina was reattached in 92% of cases.Conclusions. Combined PPV and PKP with the use of wide-field Landers TKP allowed for surgical intervention in patients with vitreoretinal pathology coexisting with corneal wound. Although retina was attached in most of the cases, corneal graft survived only in one-fourth of patients and final visual acuities were poor.

TO ANALYZE THE EFFECT OF DAMAGE TO OTHER OCULAR TISSUES ON VISUAL OUTCOME AFTER TRAUMATIC CATARACT SURGERY.

2019 ◽  
Vol 3 (9) ◽  
Author(s):  
Dr. Mita V. Joshi ◽  
Dr. Sudhir Mahashabde
Keyword(s):  
Visual Outcome ◽  
Corneal Opacity ◽  
Research Centre ◽  
Traumatic Cataract ◽  
Visual Axis ◽  
College Hospital ◽  
Ocular Tissues ◽  
Department Of Ophthalmology ◽  
Ocular Injuries ◽  
Final Visual Outcome

All patient coming to Index Medical College Hospital & Research Centre, Indore operated in Department of Ophthalmology for traumatic cataract due to various injuries Result: Of the 37 patients, 19 patients (51%) showed corneal/ corneal sclera injury. 10 cases had injury to iris in the form of spincter tear, traumatic mydriasis, iris incarceration, floppy iris, posterior and anterior synechiae. Subluxation of lens was seen in 2 cases and Dislocation of lens was in 1 cases. 3 cases had corneal opacity. Old retinal detachment was seen in 1 (3%) case. Out of 30 cases who had associated ocular injuries, 3 cases had vision of HM, 07 cases had vision of CF-ctf – CF-3’, 01 cases had vision of 5/60, 07 cases had vision of 6/60-6/36, 03 cases had vision of 6/24-6/18, 09 cases had vision of 6/12-6/6. Out of 7 cases without associated in injury, 2 cases had vision of 6/24-6/18, 05 cases had vision of 6/12-6/6. Conclusion: Corneal scarring obstructing the visual axis as well as by inducing irregular astigmatism formed an important cause of poor visual outcome in significant number of cases. Irreversible posterior segment damage lead to impaired vision case. The final visual outcome showed good result however the final visual outcome depends upon the extent of associated ocular injuries. Effective Intervention and management are the key points in preventing monocular blindness due to traumatic cataract. Keywords: Ocular, Tissues, Traumatic, Cataract & Surgery.

Working conditions and occupational risks of anterior eye pathology in metalworking machine operators

2020 ◽  
pp. 462-467
Author(s):  
N. I. Latyshevskaya ◽  
M. A. Alborova ◽  
L. A. Davydenko ◽  
A. V. Belyaevа
Keyword(s):  
Working Conditions ◽  
Work Experience ◽  
Anterior Segment ◽  
Tear Film ◽  
Corneal Opacity ◽  
Occupational Risks ◽  
Machine Operators ◽  
Comparison Groups ◽  
Working Groups ◽  
Visual Organ

Introduction. The profession of “machine operator in metalworking”, one of the most common professions in various industries, characterized by a large volume of abrasive operations, accompanied by dust formation, which creates a potential for the occurrence of diseases of the visual organ.The aim of the study is to provide a hygienic assessment of working conditions and occupational risk of visual organ pathology in metalworking machine operators.Materials and methods. Observation groups — machine operators for metalworking of two training groups (experience up to 5 years, experience of 6–20 years). Two comparison groups (administrative and technical personnel of the enterprise) are formed according to the same age-experience principle.Results. The working conditions of machine operators were classified as class 3.2. taking into account the severity and intensity of the work process and the noise level (80 dBA) in the workplace. Nitrogen oxide, carbon monoxide, and manganese were registered in the air of the working area in concentrations below the permissible concentration (PC), and the aerosol dihydroxide was registered above the PC in 25.8% of cases. In the main working groups, diseases of the anterior segment of the eye were more often registered, among which dry eye syndrome (DYS) prevailed (94.1%), chronic blepharoconjunctivitis (79.9%), persistent corneal opacification (21.7%). There was an increase in the prevalence of detected diseases with an increase in work experience (p≤0.05). In machine operators, the frequency of inhibition of lacrimal formation and decreased stability of the tear film was recorded significantly more often, with increasing work experience, the degree of violation of lacrimal formation and stability of the tear film increased. The chances of detecting pathology of the anterior segment of the eye in machine operators are 5.9 and 3.5 times higher than in the comparison group. There are different forces of connection, increasing with the increase of work experience in the profession, between the working conditions of machine operators and the occurrence of SHG (relatively strong), with chronic blepharoconjunctivitis and persistent corneal opacity (medium strength), which suggests the professional conditionality of this pathology.Conclusions. The results obtained suggest that the pathology of the anterior segment of the eye is professionally conditioned in metalworking machine operators and necessitate the introduction of preventive measures aimed at protecting the visual organ.

scholarly journals First Molecular Confirmation of Equine Ocular Setaria digitata in China

2021 ◽  
Vol 8 (4) ◽  
pp. 55
Author(s):  
Feng Yu ◽  
Bo Liu ◽  
Shulei Chen ◽  
Ziwen Yi ◽  
Xianyong Liu ◽  
...  
Keyword(s):  
Phylogenetic Analysis ◽  
Light Microscopy ◽  
Corneal Opacity ◽  
12S Rrna ◽  
Rrna Gene ◽  
Asian Countries ◽  
Setaria Digitata ◽  
12S Rrna Gene ◽  
The Right ◽  
Ocular Discharge

A 5-year-old Mongolian mare (Equus caballus Linnaeus, 1758) was observed to have corneal opacity and excessive ocular discharge. An ophthalmic examination revealed a moving thread-like cylindrical worm in the anterior chamber of the right eye. The parasite was successfully removed surgically. The worm was observed under light microscopy and confirmed as Setaria digitata by 12S rRNA gene amplification and sequencing. Phylogenetic analysis demonstrated similarity with Setaria digitata in the National Center for Biotechnology Information (NCBI) GenBank database isolated from other Asian countries. This report is the first confirmed case of equine ocular setariasis by molecular diagnosis in China, which may indicate its presence in livestock and promote research on its epidemiology.

Glutamic Acid Uptake Inhibition Assay in Cultured Hep G2 Cells as an Alternative Method for Evaluating Potential In Vivo Eye Irritation

1989 ◽  
Vol 16 (4) ◽  
pp. 344-352
Author(s):  
Paul J. Dierickx
Keyword(s):  
Glutamic Acid ◽  
Corneal Opacity ◽  
Acid Uptake ◽  
Hep G2 ◽  
Hep G2 Cells ◽  
Eye Irritation ◽  
Uptake Inhibition ◽  
Range Finding ◽  
G2 Cells

Glutamic acid (GA) content was measured in cultured Hep G2 cells, after treatment of the cells with test compounds. The results with 37 chemicals were compared with their respective rabbit eye irritation data, of which 17 were determined according to the OECD test, and the other 20 in range-finding studies. The chemicals were mainly organic solvents (alcohols, esters, amines, acids and others). The xenobiotics were applied to the cells for 4 hours at 5 different concentrations. The cells were then incubated for 15 minutes with tritiated GA. GA uptake inhibition was measured by liquid scintillation counting, and the results were expressed as the GI50 value, which is the concentration of test compound required to induce a 50% reduction in GA uptake. A linear correlation coefficient r = 0.66 was found between the log GI50 and the mean corneal opacity scores. This value is comparable to that obtained in total protein and uridine uptake inhibition studies. However, r = 0.81 was found when the log GI50 was compared with range-finding scores, indicating that a closer relationship exists between cytotoxicity and the latter.

scholarly journals Effects of intravitreal injection of siRNA against caspase-2 on retinal and optic nerve degeneration in air blast induced ocular trauma

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Chloe N. Thomas ◽  
Alexandra Bernardo-Colón ◽  
Ella Courtie ◽  
Gareth Essex ◽  
Tonia S. Rex ◽  
...  
Keyword(s):  
Intravitreal Injection ◽  
Fluorescent Protein ◽  
Ocular Trauma ◽  
Ganglion Cells ◽  
Intravitreal Injections ◽  
Nerve Degeneration ◽  
Injection Timing ◽  
Air Blast ◽  
Neuroprotective Therapy ◽  
Caspase 2

AbstractOcular repeated air blast injuries occur from low overpressure blast wave exposure, which are often repeated and in quick succession. We have shown that caspase-2 caused the death of retinal ganglion cells (RGC) after blunt ocular trauma. Here, we investigated if caspase-2 also mediates RGC apoptosis in a mouse model of air blast induced indirect traumatic optic neuropathy (b-ITON). C57BL/6 mice were exposed to repeated blasts of overpressure air (3 × 2 × 15 psi) and intravitreal injections of siRNA against caspase-2 (siCASP2) or against a control enhanced green fluorescent protein (siEGFP) at either 5 h after the first 2 × 15 psi (“post-blast”) or 48 h before the first blast exposure (“pre-blast”) and repeated every 7 days. RGC counts were unaffected by the b-ITON or intravitreal injections, despite increased degenerating ON axons, even in siCASP2 “post-blast” injection groups. Degenerating ON axons remained at sham levels after b-ITON and intravitreal siCASP2 “pre-blast” injections, but with less degenerating axons in siCASP2 compared to siEGFP-treated eyes. Intravitreal injections “post-blast” caused greater vitreous inflammation, potentiated by siCASP2, with less in “pre-blast” injected eyes, which was abrogated by siCASP2. We conclude that intravitreal injection timing after ocular trauma induced variable retinal and ON pathology, undermining our candidate neuroprotective therapy, siCASP2.

Gamma-Irradiated Cornea in Combat-related Ocular Trauma

2020 ◽  
Author(s):  
Brian M Davis ◽  
Carson Clabeaux ◽  
Anton Vlasov ◽  
Paul Houghtaling
Keyword(s):  
Ocular Trauma ◽  
Cost Savings ◽  
Corneal Tissue ◽  
Significant Cost ◽  
Visual Rehabilitation ◽  
Military Health ◽  
Corneal Injury ◽  
Gamma Irradiated ◽  
The Military ◽  
Penetrating Ocular Trauma

ABSTRACT Corneal injury is a known risk for deployed troops worldwide. To the authors’ knowledge, there has been no reported use of gamma-irradiated corneas in the setting of severe corneal trauma. Our report highlights the case of a 36-year-old active duty solider who sustained bilateral penetrating ocular trauma from a nearby ordnance explosion. We propose that ocular surgeons should consider utilizing gamma-irradiated corneas in (1) a situation where the corneal tissue is so damaged that it would be challenging to accomplish an adequate repair while providing the opportunity for future visual rehabilitation and (2) remote and/or deployed environments where storage of fresh donor tissue is limited. The long shelf life of gamma-irradiated corneas reduces the need for specialized storage equipment and the need for continuous resupply, both potentially leading to significant cost savings for the Military Health System.

Blunt ocular trauma: What is hidden behind?

2021 ◽  
Vol 22 ◽  
pp. 100987
Author(s):  
M.J. Vicente Altabás ◽  
B. Arias-Peso ◽  
M.A. Vicente Altabás
Keyword(s):  
Ocular Trauma ◽  
Blunt Ocular Trauma
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