Lipoprotein(a) serum levels and apolipoprotein(a) phenotypes in children with chronic renal disease

Objective To evaluate the distribution pattern of apolipoprotein(a) [Apo(a)] phenotypes in Koreans and the effect of dialysis modality on serum lipoprotein(a) [Lp(a)] concentration according to apo(a) phenotype in patients with end-stage renal disease (ESRO). Design Cross-sectional study. Setting A university hospital. Participants: 153 normal controls, 99 hemodialysis (HO) patients and 82 continuous ambulatory peritoneal dialysis (CAPO) patients. Main Outcome Measures Fasting serum Lp(a), lipids, and apo(a) phenotypes were measured. Results The frequencies of the subjects with apo(a) phenotypes of high-molecular weight only, including S3, S4, or S5 or null type were 95.4% of control, 100% of HO patients, and 95.1% of CAPO patients. The frequent apo(a) phenotypes in Koreans consisted of S4, S4S5, S5, and S5S5 isoforms. Significant difference was found in serum Lp(a) concentration among controls and HO and CAPO patients [median (interquartile range): 0.05 g/L, (0.01 0.19); 0.19g/L, (0.10 0.35); 0.63g/L, (0.28 0.90), p< 0.001]. Lp(a) levels in CAPO patients were significantly higher than in HO patients for all four common apo(a) isoforms found in Korean subjects. CAPO patients had higher total and LOL cholesterol levels, and higher ApoB levels than H O patients. Significant differences were found in serum albumin levels between controls and HO and CAPO patients (44 ± 3 g/L, 40 ± 4 g/L, 32 ± 7 g/L, respectively, p < 0.05). There were significant inverse correlations between serum albumin and Lp(a) (r = -0.33, p < 0.01), total cholesterol (r = -0.31, p < 0.01), LOL (r = -0.39, p < 0.01) or ApoB (r = -0.35, p < 0.01) in ESRO patients. A significant positive correlation was found between serum albumin and ApoA1 (r = 0.24, p < 0.01). Conclusion These findings indicate that Koreans have mainly high -molecular weight apo(a) phenotypes and serum Lp(a) is elevated in CAPO patients compared to HO patients for common apo(a) phenotypes, which may contribute to the frequent cardiovascular mortality in CAPO patients.

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Elevated plasma concentrations of lipoprotein(a) in patients with end-stage renal disease are not related to the size polymorphism of apolipoprotein(a).

Journal of Clinical Investigation ◽

10.1172/jci116213 ◽

1993 ◽

Vol 91 (2) ◽

pp. 397-401 ◽

Cited By ~ 82

Author(s):

H Dieplinger ◽

C Lackner ◽

F Kronenberg ◽

C Sandholzer ◽

K Lhotta ◽

...

Keyword(s):

Renal Disease ◽

End Stage Renal Disease ◽

Plasma Concentrations ◽

Elevated Plasma ◽

Lipoprotein A ◽

Size Polymorphism ◽

Apolipoprotein A ◽

Stage Renal Disease ◽

End Stage

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Lipoprotein(a) and treatment of chronic renal disease

Journal of Internal Medicine ◽

10.1111/j.1365-2796.1993.tb00777.x ◽

1993 ◽

Vol 234 (5) ◽

pp. 453-455 ◽

Cited By ~ 11

Author(s):

D. BUGGY ◽

A. BREATHNACH ◽

B. KEOGH ◽

T. COOKE ◽

J. FEELY

Keyword(s):

Renal Disease ◽

Chronic Renal Disease ◽

Lipoprotein A

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Early Expression of the Apolipoprotein (a) Gene: Relationships Between Infants' and Their Parents' Serum Apolipoprotein (a) Levels

PEDIATRICS ◽

10.1542/peds.89.3.401 ◽

1992 ◽

Vol 89 (3) ◽

pp. 401-406 ◽

Cited By ~ 1

Author(s):

Xing L. Wang ◽

David E. L. Wilcken ◽

Nicholas P. B. Dudman

Keyword(s):

Positive Family History ◽

Serum Levels ◽

Serum Lipoprotein ◽

Parental Values ◽

Lipoprotein A ◽

Apolipoprotein A ◽

Early Expression ◽

High Concentrations ◽

Family Based ◽

Highly Correlated

The serum concentration of apo(a), the unique apolipoprotein of lipoprotein (a), reflects serum lipoprotein (a) levels. High concentrations are associated with increased cardiovascular risk. Inasmuch as atherogenesis may begin in childhood, the early expression of the apo(a) gene and relationships between serum levels in infants and their parents were explored. Serum apo(a) and lipid profiles were measured in 51 infants when aged 8.5 ± 2 months. They were from among 1032 consecutively born babies in whom apo(a) levels had been measured on day 2 to 5. Levels in 18 infants were in the top 5% of the neonatal apo(a) distribution and in 33 from below the 95th percentile. Parental values were also assessed. Infants' apo(a) levels (n = 51) at the ages of 2 to 5 days and 8.5 ± 2.3 months were highly correlated (r .73, P < .0001) and increased from an initial median value of 48 U/L (range 1 to 462 U/L) to 100 U/L (5 to 969 U/L) at 8.5 months, and they were then not different from parental levels. Measurements at both times were closely correlated with parental levels. Regression coefficients between 8.5-month levels, and the levels of fathers, of mothers, and the average level of both parents were 0.439, 0.521 and 0.93, respectively (P < .0001 for each). It is concluded that the gene for the regulation of apo(a) is fully expressed before the age of 1 year. The apo(a) levels in infants during this time track closely and are predictive of parental values. These results are consistent with apo(a) contributing to that part of coronary risk associated with a positive family history, with implications for both future childhood screening and family-based coronary prevention.

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Lipoprotein(a), apolipoprotein A-I and B serum levels in young families from Tallinn, Estonia. Relationships with other cardiovascular risk factors and nationality

Scandinavian Journal of Clinical and Laboratory Investigation ◽

10.1080/00365519950185706 ◽

1999 ◽

Vol 59 (3) ◽

pp. 179-189 ◽

Cited By ~ 4

Author(s):

K Aasvee ◽

M Jauhiainen ◽

E Kurvinen ◽

R Jordania ◽

J Sundvall ◽

...

Keyword(s):

Risk Factors ◽

Cardiovascular Risk ◽

Cardiovascular Risk Factors ◽

Serum Levels ◽

Lipoprotein A ◽

Apolipoprotein A

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Relationship Between Periodontal Disease and Serum Factors in Patients Undergoing Hemodialysis

The Open Dentistry Journal ◽

10.2174/1874210601711010701 ◽

2017 ◽

Vol 11 (1) ◽

pp. 701-709 ◽

Cited By ~ 3

Author(s):

Narges Naghsh ◽

Negar Kanuni Sabet ◽

Forozan Vahidi ◽

Ahmad Mogharehabed ◽

Jaber Yaghini

Keyword(s):

Serum Level ◽

Periodontal Disease ◽

Renal Disease ◽

Cystatin C ◽

Chronic Renal Disease ◽

Serum Levels ◽

Pocket Depth ◽

Clinical Attachment Loss ◽

Cross Sectional ◽

Serum Factors

Background:Chronic renal disease is a common condition with several recognized risk factors. Periodontal disease is a recently suggested risk factor for renal disease. We aimed to assess the relationship between periodontal disease and several serum factors in patients undergoing hemodialysis.Methods:This descriptive cross-sectional study was conducted on 57 patients undergoing hemodialysis. Periodontal examination was done by measuring the mean Pocket Depth (PD), Silness-Löe Plaque Index (PI), Ainamo and Bay Bleeding On Probing (BOP), Löe and Silness Gingival Index (GI) and Clinical Attachment Loss (CAL). Serum levels of albumin, calcium, phosphorus, hemoglobin, ferritin and creatinine were measuredviaa routine blood test. Cystatin C was separately measured. Data were analyzed using independent t-test, Pearson’s correlation coefficient, chi square test and Mann Whitney test (alpha=0.05).Results:37 men and 20 women were evaluated. Of these, 26.3% had periodontitis and 73.7% had gingivitis. Serum level of albumin (P=0.02) and ferritin (P=0.043) in patients with periodontitis was significantly higher than that in patients with gingivitis. The serum level of creatinine (P=0.02), cystatin C (P=0.013), calcium (P=0.046) and phosphorus (P=0.037) had a significant correlation with severity of periodontitis and increase in CAL.Conclusion:Increase in the serum levels of albumin and ferritin was related to the progression of gingivitis to periodontitis. Also, the serum levels of creatinine, cystatin C, calcium and phosphorus increased with an increase in CAL.

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