Long term effects of vincristine on the peripheral nervous system

1993 ◽  
Vol 15 (1) ◽  
pp. 23-27 ◽  
Author(s):  
T. J. Postma ◽  
B. A. Benard ◽  
P. C. Huijgens ◽  
G. J. Ossenkoppele ◽  
J. J. Heimans
Keyword(s):  
Nervous System ◽  
Peripheral Nervous System ◽  
Long Term Effects

Long-Term Effects of 2,3,7,8-Tetrachlorodibenzo-p-Dioxin on the Peripheral Nervous System

1987 ◽  
Vol 7 (1) ◽  
pp. 29-37 ◽  
Author(s):  
Sergio Barbieri ◽  
Carlo Pirovano ◽  
Guglielmo Scarlato ◽  
Paolo Tarchini ◽  
Alessandro Zappa ◽  
...  
Keyword(s):  
Nervous System ◽  
Peripheral Nervous System ◽  
Long Term Effects

20. Long-term effects of vincristine on the peripheral nervous system

1992 ◽  
Vol 94 (1) ◽  
pp. 80
Author(s):  
T.J. Postma ◽  
B.A. Benard ◽  
P.C. Huijgens ◽  
G.J. Ossenkoppele ◽  
J.J. Heimans
Keyword(s):  
Nervous System ◽  
Peripheral Nervous System ◽  
Long Term Effects

scholarly journals Long-term effects of mercury intoxication in the peripheral nervous system

2014 ◽  
Vol 72 (8) ◽  
pp. 648-648
Author(s):  
Joseph B.B. Brooks ◽  
Luisa F. Rocha ◽  
Yara Dadalti Fragoso
Keyword(s):  
Nervous System ◽  
Peripheral Nervous System ◽  
Long Term Effects ◽  
Mercury Intoxication

The Long-Term Effects of Central Nervous System Therapy on Children with Brain Tumors

1991 ◽  
Vol 9 (2) ◽  
pp. 479-495 ◽  
Author(s):  
Patricia K. Duffner ◽  
Michael E. Cohen
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Brain Tumors ◽  
Long Term Effects ◽  
System Therapy

Long-Term Diffusion Impairment of Cerebral White Matter in a Degenerative Disease of the Central and Peripheral Nervous System

2011 ◽  
Vol 27 (2) ◽  
pp. 229-233
Author(s):  
Katrin Sabine Blum ◽  
Christian Hagel ◽  
Eva Neuen-Jacob ◽  
Peter Herkenrath ◽  
Jens Fiehler ◽  
...  
Keyword(s):  
Nervous System ◽  
White Matter ◽  
Peripheral Nervous System ◽  
Degenerative Disease ◽  
Cerebral White Matter

scholarly journals Maternal Overnutrition Induces Long-Term Cognitive Deficits across Several Generations

Nutrients ◽  
2018 ◽  
Vol 11 (1) ◽  
pp. 7 ◽  
Author(s):  
Gitalee Sarker ◽  
Daria Peleg-Raibstein
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Cognitive Deficits ◽  
Maternal Obesity ◽  
Cognitive Impairments ◽  
Long Term Effects ◽  
Ample Evidence ◽  
Increased Risk ◽  
Maternal Overnutrition

Ample evidence from epidemiological studies has linked maternal obesity with metabolic disorders such as obesity, cardiovascular disease, and diabetes in the next generation. Recently, it was also shown that maternal obesity has long-term effects on the progeny’s central nervous system. However, very little is known regarding how maternal overnutrition may affect, in particular, the cognitive abilities of the offspring. We reported that first-generation offspring exposed to a maternal high-fat diet (MHFD) displayed age-dependent cognitive deficits. These deficits were associated with attenuations of amino acid levels in the medial prefrontal cortex and the hippocampus regions of MHFD offspring. Here, we tested the hypothesis that MHFD in mice may induce long-term cognitive impairments and neurochemical dysfunctions in the second and third generations. We found that MHFD led to cognitive disabilities and an altered response to a noncompetitive receptor antagonist of the N-Methyl-D-aspartic acid (NMDA) receptor in adult MHFD offspring in both second and third generations in a sex-specific manner. Our results suggest that maternal overnutrition leads to an increased risk of developing obesity in subsequent generations as well as to cognitive impairments, affecting learning and memory processes in adulthood. Furthermore, MHFD exposure may facilitate pathological brain aging which is not a consequence of obesity. Our findings shed light on the long-term effects of maternal overnutrition on the development of the central nervous system and the underlying mechanisms which these traits relate to disease predisposition.

95 LONG TERM EFFECTS OF ZINC IN THE CENTRAL NERVOUS SYSTEM OF RATS

1980 ◽  
Vol 39 (3) ◽  
pp. 368 ◽  
Author(s):  
Y. Kress ◽  
F. Gaskin ◽  
C. Brosnan ◽  
S. Levine
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Long Term Effects ◽  
The Central Nervous System

BDNF overexpression produces a long-term increase in myelin formation in the peripheral nervous system

2004 ◽  
Vol 77 (5) ◽  
pp. 662-669 ◽  
Author(s):  
Ravi J. Tolwani ◽  
Jos� M. Cosgaya ◽  
Sushama Varma ◽  
Reza Jacob ◽  
Lydia E. Kuo ◽  
...  
Keyword(s):  
Nervous System ◽  
Peripheral Nervous System ◽  
Myelin Formation

Long-term effects of early pain and injury

2021 ◽  
pp. 21-37
Author(s):  
Orla Moriarty ◽  
Suellen M. Walker
Keyword(s):  
Nervous System ◽  
Early Life ◽  
Tissue Injury ◽  
Afferent Input ◽  
Laboratory Studies ◽  
Long Term Effects ◽  
Nociceptive Pathways ◽  
Noxious Stimuli ◽  
Underlying Mechanisms

Nociceptive pathways are functional following birth, and acute responses to noxious stimuli have been documented from early in development in clinical and laboratory studies. The ability of noxious afferent input to alter the level of sensitivity of nociceptive pathways in the adult nervous system, with, for example, the development of central sensitization, is well established. However, the developing nervous system has additional susceptibilities to alterations in neural activity, and pain in early life may produce effects not seen following the same input at older ages. As a result, early tissue injury may lead to persistent changes in somatosensory processing and altered sensitivity to future noxious stimuli. Furthermore, there is increasing evidence that neonatal pain can result in long-term changes in cognitive and affective behavior. Effects of pain in early life are superimposed on a highly plastic developing system, and long-term outcomes vary depending on the type and severity of the injury, and on the evaluation methods used. Laboratory studies allow evaluation of different injuries, potential confounding factors, underlying mechanisms, and potential analgesic modulation.

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