Intestinal duplication detected with technetium-99m sodium pertechnetate imaging of the abdomen

1977 ◽  
Vol 22 (12) ◽  
pp. 1122-1126 ◽  
Author(s):  
Ronald M. Barkley ◽  
Otto Munoz ◽  
Robert W. Parkey
Keyword(s):  
Intestinal Duplication ◽  
Technetium 99M ◽  
Sodium Pertechnetate

99mTc Technetium Sulfide and the Scintillation Camera in the Rapid Diagnosis of Pericardial Effusion

1971 ◽  
Vol 10 (02) ◽  
pp. 122-128
Author(s):  
W. H. Blahd ◽  
M. A. Winston ◽  
G. T. Krishnamurthy ◽  
P. B. Thomas ◽  
E. Weiss
Keyword(s):  
Pericardial Effusion ◽  
Patient Positioning ◽  
Rapid Diagnosis ◽  
Scintillation Camera ◽  
Technical Error ◽  
Technetium 99M ◽  
Sodium Pertechnetate ◽  
Specific Uptake ◽  
Speed Accuracy

SummaryBecause of its speed, accuracy, and reproducibility, radioisotopic angiocardiography appears to be the method of choice for the diagnosis of pericardial effusion. Technetium-99m sulfide is preferable to 99mTc sodium pertechnetate in these studies for the following reasons: (1) its specific uptake by the liver aids both in patient positioning and in the accuracy of diagnosis; and (2), studies can be repeated within 15—20 minutes should there be equiment or technical error.

scholarly journals Experimental models using radionuclides for assessment of the effects of natural drugs

2008 ◽  
Vol 51 (spe) ◽  
pp. 169-174 ◽  
Author(s):  
Silvana Ramos Farias Moreno ◽  
Jorge José de Carvalho ◽  
Bernardo Rebello ◽  
Emely Kazan Rocha ◽  
Margareth de Oliveira Timóteo ◽  
...  
Keyword(s):  
Red Blood Cells ◽  
Ginkgo Biloba ◽  
Blood Cells ◽  
Experimental Models ◽  
Significant Alteration ◽  
Blood Constituents ◽  
Technetium 99M ◽  
Sodium Pertechnetate ◽  
Natural Drugs

The aim of this study was to evaluate the effect of the extracts of Nectandra membranacea (N. membranacea), Ginkgo biloba (EGb) and Passiflora (PEF) on the morphology of red blood cells (RBC), on the biodistribution of sodium pertechnetate (99mTcO4Na), on the morphology of duodenum and on the labeling of blood constituents (BC, IF-P, IF-BC) with technetium-99m (Tc-99m). Morphometry studies also were performed. The results show that EGb promotes alteration of the labeling of BC, IF-P and IF-BC (p<0.05). The N. membranacea extract does not promote significant alteration of the radiolabeling, and PEF extract alters the IF-P labeling. N. membranacea, EGb and PEF extracts were able to alter the RBC morphology (P<0.05). N. membranacea extract and EGb modifies the biodistribution of the 99mTcO4Na, and EGb influences the morphometry of duodenum isolated from rats (P<0.05).

Intestinal Duplication: Imaging With Tc-99m Sodium Pertechnetate

1996 ◽  
Vol 21 (12) ◽  
pp. 968 ◽  
Author(s):  
CHARLES L. TORGERSON ◽  
DANIEL W. YOUNG ◽  
YOGINDER N. VAID ◽  
KEITH E. GEORGESON ◽  
DAVID R. KELLY
Keyword(s):  
Intestinal Duplication ◽  
Sodium Pertechnetate

scholarly journals Biodistribution of technetium-99m pertechnetate after Roux-en-Y gastric bypass (Capella technique) in rats

2010 ◽  
Vol 25 (1) ◽  
pp. 9-12 ◽  
Author(s):  
Amália Cínthia Meneses do Rêgo ◽  
Irami Araújo-Filho ◽  
Ítalo Medeiros Azevedo ◽  
Daniel Tôrres Jácome ◽  
Rachel de Alcântara Oliveira Ramalho ◽  
...  
Keyword(s):  
Bariatric Surgery ◽  
Gastric Bypass ◽  
Nuclear Medicine ◽  
Statistical Analysis ◽  
T Test ◽  
Control Group ◽  
Technetium 99M ◽  
Sodium Pertechnetate ◽  
Significant Difference

PURPOSE: The biodistribution of sodium pertechnetate, the most used radiopharmaceutical in nuclear medicine, has not been studied in details after bariatric surgery. The objective was to investigate the effect of Roux-en-Y gastric bypass (RYGB) on biodistribution of sodium pertechnetate (Na99mTc-) in organs and tissues of rats. METHODS: Twelve rats were randomly divided into two groups of 6 animals each. The RYGB group rats were submitted to the Roux-en-Y gastric bypass and the control group rats were not operated. After 15 days, all rats were injected with 0.1mL of Na99mTc- via orbital plexus with average radioactivity of 0.66 MBq. After 30 minutes, liver, stomach, thyroid, heart, lung, kidney and femur samples were harvested, weighed and percentage of radioactivity per gram (%ATI/g) of each organ was determined by gama counter Wizard Perkin-Elmer. We applied the Student t test for statistical analysis, considering p<0.05 as significant. RESULTS: Significant reduction in mean %ATI/g was observed in the liver, stomach and femur in the RYGB group animals, compared with the control group rats (p<0.05). In other organs no significant difference in %ATI/g was observed between the two groups. CONCLUSION: This work contributes to the knowledge that the bariatric surgery RYGB modifies the pattern of biodistribution of Na99mTc-.

scholarly journals Effect of medicinal plants on the parasitemia of Trypanosoma cruzi and on the biodistribution of sodium pertechnetate (Na99mTcO4)

2008 ◽  
Vol 51 (spe) ◽  
pp. 209-214 ◽  
Author(s):  
Roseane Pereira da Silva ◽  
Cecília Maria de Carvalho Xavier Holanda ◽  
Vanessa Santos de Arruda Barbosa ◽  
Daniel Pereira de Oliveira ◽  
Natália Alves Lima ◽  
...  
Keyword(s):  
Nuclear Medicine ◽  
Medicinal Plants ◽  
Trypanosoma Cruzi ◽  
Antimalarial Drug ◽  
Biological Effects ◽  
Aloe Vera ◽  
Artemisia Vulgaris ◽  
Technetium 99M ◽  
Sodium Pertechnetate ◽  
Plant Effects

Artemisia vulgaris (AV) is an antihelmintic and antimalarial drug; Aloe vera(babosa) acts as antidiabetic, laxative and anti-inflammatory;Benznidazole (BZ) is a trypanocidal of Trypanosoma cruzi (TC). Technetium-99m (99mTc) has been used in nuclear medicine to obtain diagnostic images. This study evaluated the plant effects in TC parasitemia and on the biodistribution of 99mTc in mice. Twenty mice were infected by TC. At the peak of parasitemia, 5 mice received babosa; 5 received AV and 5 received BZ. The parasitemia was determined at 0, 2, 4 and 6 h of drugs administration. Five infected mice without drugs, 5 mice without TC and the group treated with AV, received 99mTc. The radioactivity was calculated. Infected mice that received babosa reduced significantly (p<0.05) the TC parasitemia. The percentage of activity per gram (%ATI/g) decreased significantly on the AV group. These results indicate that babosa possibly is an anti-TC drug and AV reduces the %ATI/g probably due to its biological effects.

scholarly journals Technetium-99m in production and use

2009 ◽  
Vol 24 (1) ◽  
pp. 68-73 ◽  
Author(s):  
Jurij Vucina ◽  
Nadezda Nikolic ◽  
Djokica Petrovic
Keyword(s):  
Nuclear Reactions ◽  
Technetium 99M ◽  
Sodium Pertechnetate ◽  
99Mtc Radiopharmaceuticals ◽  
99Mtc Generator ◽  
Uranium Fission

Several types of generators have been developed for the production of 99mTc. Due to its excellent performances, the chromatographic type, based on the fission-produced 99Mo sorbed in alumina, is predominant. Technetium-99m is obtained in the form of sodium pertechnetate-99mTc. However, due to the known disadvantages of the production of (n, f)99Mo, attempts are made to avoid uranium fission. The technologies based on (n, g)99Mo (sublimation, extraction, gel) are, with the exception of the gel generator, of limited importance. Certain nuclear reactions in cyclotrons can produce 99Mo (or directly 99mTc) but the obtained results are still not satisfying. Technetium-99m is used in the form of radiopharmaceuticals which are prepared by addition of 99mTc-eluate to the inactive components comprised in the 'cold' kits. The chromatographic (n, f)99Mo/99mTc generator and several 99mTc-radiopharmaceuticals have been developed and are regularly produced in the Vinca Institute of Nuclear Sciences (Laboratory for Radioisotopes).

scholarly journals Effects of chronic sucralose sweetener on the labeling of blood constituents with technetium-99m, morphology of red blood cells and the biodistribution of sodium pertechnetate in rats

2008 ◽  
Vol 51 (spe) ◽  
pp. 127-133 ◽  
Author(s):  
Gabrielle de Souza Rocha ◽  
Marcia de Oliveira Pereira ◽  
Mônica de Oliveira Benarroz ◽  
Jacques Natan Grinapel Frydman ◽  
Angélica Beatriz Garcia-Pinto ◽  
...  
Keyword(s):  
Red Blood Cells ◽  
Blood Cells ◽  
Wistar Rats ◽  
Quantitative Morphology ◽  
Blood Samples ◽  
Blood Constituents ◽  
Qualitative And Quantitative ◽  
Technetium 99M ◽  
Sodium Pertechnetate ◽  
Blood Smears

This work evaluates effects of the sweetener with sucralose on the labeling of blood constituents with technetium-99m (99mTc), on the morphology of red blood cells (RBC) and on the biodistribution of sodium pertechnetate in Wistar rats. Animals were treated with sweetener for 8 days. Blood samples were withdrawn and the assay of labeling of blood constituents with 99mTc was performed. Blood cells (BC) and plasma (P) were isolated. Aliquots of BC and P were also precipitated, soluble and insoluble fractions separated. The radioactivity in each fraction was counted and percentage of incorporated radioactivity (%ATI) determined. Blood smears were prepared, fixed, stained and the qualitative and quantitative morphology of the RBC was evaluated under optical microscopy. In biodistribution experiments, sodium pertechnetate was administrated, organs and tissues isolated, radioactivity was counted and percentage of incorporated radioactivity per gram (%ATI/g) determined. The data showed no significant alterations in %ATI, morphology of RBC and in %ATI/g in the studied organs.

Altered Distribution of Technetium-99m Sodium Pertechnetate Associated with Antimicrobial Therapy

1985 ◽  
Vol 10 (12) ◽  
pp. 868-871 ◽  
Author(s):  
J J CASTRONUOVO ◽  
L R CHERVU ◽  
D M MILSTEIN
Keyword(s):  
Antimicrobial Therapy ◽  
Technetium 99M ◽  
Sodium Pertechnetate

scholarly journals Experience in Validation of Methods for Determination of Radiochemical Impurities in Radiopharmaceuticals

2020 ◽  
Vol 10 (4) ◽  
pp. 244-256
Author(s):  
A. O. Malysheva ◽  
G. E. Kodina ◽  
E. A. Lyamtseva ◽  
N. A. Taratonenkova ◽  
A. S. Lunev
Keyword(s):  
Silica Gel ◽  
Analytical Methods ◽  
Experimental Studies ◽  
Sodium Acetate Solution ◽  
Acetate Solution ◽  
Technetium 99M ◽  
Sodium Pertechnetate ◽  
Validation Of Methods ◽  
Validation Parameters

Most important quality attributes of any radiopharmaceutical (RPh) are its radiochemical purity (RCP) or content of radiochemical impurities (RCIs) that have to comply with respective norms and limits. However, at present, there is no unified approach to validation of analytical methods in the context of highly radioactive samples.The aim of the study was to develop an approach to validation of methods for determination of RCI content in RPhs.Materials and methods: the authors determined the content of RCIs in a radiopharmaceutical formulation containing a complex of technetium-99m and methylenediphosphonic acid by the radiometric method after isolation of impurities from the main compound by thin-layer chromatography using silica gel and methyl ethyl ketone (for sodium pertechnetate determination) and silica gel and 13.6% sodium acetate solution (for determination of hydrolysed reduced technetium-99m). The radioactivity was registered by a chromatogram scanner with a detector of gamma-rays with energies from 0.05 to 1.5 MeV.Results: the paper analyses existing official approaches to validation of analytical procedures and compares them with the results of experimental studies described in available publications. It assesses the validation parameters for compliance with the acceptance criteria set forth in the current regulations and substantiates selectivity of chromatographic determination of impurities under the selected test conditions. Coefficients of variation for repeatability, reproducibility, and accuracy did not exceed 4.5, 2.8, and 8.9%, respectively, given the relative error of not more than 10.5%. The study demonstrated signal linearity for the 10-fold dilution of the standardised sodium pertechnetate solution, it also demonstrated correspondence between the applied and detected radioactivity when performing the test in the impurity content range of 0.5–5%. The validation procedure was associated with significant radiation burden for the personnel of the quality control laboratory.Conclusions: the authors suggested a methodological approach to validation of methods for determination of RCI content in technetium-99m-based RPhs. This approach may be used in the development of a guideline on validation of analytical methods for RCP/RCI determination in RPhs, or for introduction of relevant sections into existing documents.

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