The effect of chronic unpredictable stress on locomotor and exploratory activity in male rats with different endogenous prolactin levels

1992 ◽  
Vol 89 (3) ◽  
pp. 179-192 ◽  
Author(s):  
L. N. Fracchia ◽  
A. S. Gonz�lez Jatuff ◽  
E. O. Alvarez
Keyword(s):  
Exploratory Activity ◽  
Male Rats ◽  
Chronic Unpredictable Stress

Pineal indols and testosterone affect exploratory activity of male rats

1984 ◽  
Vol 40 (4) ◽  
pp. 397-398 ◽  
Author(s):  
M. Rodriguez ◽  
J. Sosa ◽  
G. Hernandez ◽  
M. Mas
Keyword(s):  
Exploratory Activity ◽  
Male Rats

scholarly journals Effects of Two Types of Restraint Stress on the Spontaneous Behaviour in Rats

2004 ◽  
Vol 47 (3) ◽  
pp. 177-180 ◽  
Author(s):  
Lenka Trnečková ◽  
Pavel Šída ◽  
Sixtus Hynie ◽  
Ivan Krejčí ◽  
Zdeněk Hliňák ◽  
...  
Keyword(s):  
Restraint Stress ◽  
Open Field Test ◽  
Exploratory Activity ◽  
Behavioural Response ◽  
Male Rats ◽  
Cognitive Responses ◽  
Activity Levels ◽  
Strong Suppression ◽  
Partial Immersion ◽  
Wistar Male Rats

Our previous findings suggested the existence of stressor-specific behavioural and cognitive responses in rats. In the present study, restraint stressor (immobilization, IMO) and restraint stressor combined with partial immersion of rats into water (IMO+C) were applied for 1 hour to Wistar male rats and their spontaneous behaviour was examined in the open field test. The classic behavioural parameters were recorded: crossing, rearing, and resting. When tested 1 and 4 hours after IMO+C, animals exhibited strong suppression of locomotor and exploratory activity (crossing and rearing); partial inhibition of both behavioural variables was found after IMO. Thus, substantial differences were observed in dependence on the length of period between the end of stressor application and the start of testing. In testing performed one week later, the locomotor and exploratory activity levels of both IMO and IMO+C animals corresponded to the control ones. These data suggest a differential behavioural response to both used stressors that may result from their different proportion of psychical and physical components. In conclusion, our results provide other data for the support of differential effects of two types of restraint stressors on spontaneous behaviour of animals exposed to a novel environment.

scholarly journals Effect of Voluntary Exercise Training on Corticosterone Level and Immobility Behavior Induced by Chronic Stress in Rats

2020 ◽  
Vol 6 (3) ◽  
pp. 164-169
Author(s):  
Zahra Entezari ◽  
◽  
Ayyub Babaei ◽  
Saleh Rahmati-Ahmadabad ◽  
◽  
...  
Keyword(s):  
Exercise Training ◽  
Chronic Stress ◽  
Exercise Group ◽  
Voluntary Exercise ◽  
Male Rats ◽  
Depression Symptoms ◽  
Chronic Unpredictable Stress ◽  
Corticosterone Concentration ◽  
Serum Corticosterone ◽  
Immobility Time

Background: Depression is a common mood disorder that in the long-term impairs thoughts, behavior, feelings, and health. Chronic unpredictable stress is one of the factors that can cause depression. Objectives: To investigate the effect of voluntary exercise training on immobility behavior (caused by chronic unpredictable stress) and serum corticosterone concentration. Materials & Methods: A total of 24 male rats were randomly and equally assigned to four groups of healthy-control, healthy-exercise, depressed-control, and depressed-exercise. Depressed-control and depressed-exercise groups were first exposed to three weeks of chronic unpredictable stress. After this period, the exercise groups performed four weeks of voluntary exercise training. Twentyfour hours after the last training session, a forced swim test was taken from the rats and their blood samples were taken 24 hours later. The obtained data were analyzed using a 2-way analysis of variance (significance level: P<0.05). The Pearson correlation coefficient was used to examine the relationship between study variables. All statistical analyses were performed in SPSS v. 22. Results: Chronic stress increased immobility behavior (P=0.001) and serum corticosterone concentration (P=0.001). In contrast, exercise training reduced immobility behavior (P=0.001) and serum corticosterone (P=0.001). The immobility time (P=0.001) and serum corticosterone concentration in the depressed-exercise group were higher than those in the healthy-exercise group (P=0.001). There was a positive correlation between immobility behavior and serum corticosterone concentration (r=0.85 and P=0.001). Conclusion: While the chronic stress increases the immobility behavior and serum corticosterone concentration, voluntary exercise training can reduce immobility behavior and serum corticosterone and adjust some depression symptoms.

Effect of tianeptine on neuroendocrine, enzyme and behavioral responses to restraint stress in male rats

1993 ◽  
Vol 8 (S2) ◽  
pp. 67s-73s ◽  
Author(s):  
R Fontanges ◽  
J Mimouni ◽  
X de Grieve ◽  
J Picard ◽  
M Pugeat ◽  
...  
Keyword(s):  
Open Field ◽  
Restraint Stress ◽  
Wistar Rats ◽  
Chronic Treatment ◽  
Single Injection ◽  
Behavioral Responses ◽  
Chronic Administration ◽  
Exploratory Activity ◽  
Male Rats ◽  
The Novel

SummaryThe effects of the novel antidepressant tianeptine, after acute or chronic administration, were compared in normal and restraint-stressed (30 min or 2 h) Wistar rats. Tianeptine, at the dose of 10 mg/kg, did not exert any effect in non-stressed rats. However, in animals restrained for 30 min, tianeptine reduced the increase of circulating ACTH and β-endorphin levels without modification of corticosterone. Moreover, it antagonized the deficit of vertical exploratory activity in an open field. In rats restrained for 2 hours, a single injection of tianeptine suppressed the stress-induced increase of TAT hepatic activity and moderately attenuated the deficit of activity in the open field. This effect was less marked and not statistically significant after chronic treatment.

Testosterone has antidepressant-like efficacy and facilitates imipramine-induced neuroplasticity in male rats exposed to chronic unpredictable stress

2016 ◽  
Vol 79 ◽  
pp. 58-69 ◽  
Author(s):  
Steven R. Wainwright ◽  
Joanna L. Workman ◽  
Amir Tehrani ◽  
Dwayne K. Hamson ◽  
Carmen Chow ◽  
...  
Keyword(s):  
Male Rats ◽  
Chronic Unpredictable Stress

THE SULPIRIDE CORRECTION OF BEHAVIORAL DISORDERS IN ALCOHOLIZED WHITE MALE RATS WITH DIFFERENT DEGREES OF DEPRESSION

2019 ◽  
pp. 19-28
Author(s):  
Г.А. Фролова
Keyword(s):  
Open Field ◽  
Behavioral Disorders ◽  
Open Space ◽  
Elevated Plus Maze ◽  
Total Duration ◽  
Exploratory Activity ◽  
Male Rats ◽  
Behavioral Activity ◽  
Porsolt Test ◽  
Plus Maze

Целью исследования является оценка коррекции поведенческих нарушений, вызванных двухнедельной алкоголизацией у самцов белых крыс, путем блокирования сульпиридом ауторецепторов дофамина с учетом индивидуально-типологических особенностей животных. Методика. Эксперимент был выполнен на 40 половозрелых крысах-самцах массой 180-220 г. Уровень тревожности крыс определяли в приподнятом крестообразном лабиринте по общему времени пребывания животного на открытом пространстве лабиринта за 5 мин тестирования и числу повторных выходов на него. Двигательную и исследовательскую активность, а также число актов груминга животных оценивали в тесте открытого поля в течение 5 мин. Уровень депрессивности животных устанавливали с помощью теста Порсолта с подсчетом количества и общей продолжительности периодов полной иммобильности (неподвижности) животного. По количеству фекальных болюсов судили об эмоциональности животных. После исходного (контрольного) тестирования в батарее вышеуказанных тестов животные были разделены на три подгруппы согласно выраженности депрессивности в тесте Порсолта. Алкоголизацию проводили в течение 14 сут путем внутрибрюшинного введения раствора этанола в виде 10% раствора из расчета 2 г/кг веса животного, после чего животные проходили повторное тестирование в поведенческих тестах. Сульпирид («Eglonyl», Sanofi Winthrop Industrie, France) вводили в течение 14 сут в дозе 10 мг/кг, внутрибрюшинно, после чего животные снова проходили тестирование. Результаты. Двухнедельная алкоголизация приводит к увеличению тревожности и депрессивности самцов с исходно низким и средним уровнем депрессивности, на что указывает сокращение пребывания животных данных подгрупп на открытом пространстве приподнятого крестообразного лабиринта (p<0,01), уменьшение числа повторных выходов на него (p<0,05) и значительное увеличение общего времени неподвижности в тесте Порсолта (p<0,01). Последующее введение сульпирида корректирует анксиогенный и депрессогенный эффекты алкоголизации у самцов этих подгрупп. Исходно высокодепрессивные животные не проявили чувствительности к 14-дневному введению этанола и последующему блокированию D2/D3-рецепторов дофамина в приподнятом крестообразном лабиринте и тесте Порсолта. Введение этанола в течение 14 дней угнетает исследовательскую активность (p<0,01) самцов в открытом поле независимо от исходного уровня их депрессивности и двигательную (p<0,01) у низкодепрессивных животных. Последующее введение сульпирида не привело к компенсации эффекта алкоголизации на показатели поведенческой активности в открытом поле. У низкодепрессивных самцов на фоне двухнедельной алкоголизации развивается депрессивноподобное состояние, характеризующееся выраженным поведенческим дефицитом в открытом поле. Двухнедельная алкоголизация приводит к значительному (в 2-3,5 раз, p<0,01) росту эмоциональности независимо от исходного уровня депрессивности крыс, что полностью корректируется последующим введением сульпирида у высокодепрессивных самцов, и к частичному снижению проявлений эмоциональности у низко- и среднедепрессивных животных. Заключение. Полученные результаты свидетельствуют о возможности коррекции тревожных и депрессивных нарушений, возникших на фоне двухнедельной алкоголизации, сульпиридом с учетом индивидуально-типологических особенностей организма. The aim of the study was to evaluate correction of behavioral disorders with sulpiride, a dopamine autoreceptor inhibitor, in alcoholized rats taking into account individual typological features of the animals. Methods. Experiments were performed on sexually mature male rats weighing 180-220 g. The level of anxiety was determined in the elevated plus-maze by the total time of stay in and number of exits from the open space of the maze during 5 minutes of testing. Locomotor and exploratory activity and grooming behavior were assessed in the open field for 5 minutes. The severity of animal depression was determined using the standard Porsolt test by the number and total duration of immobility periods. The emotional state of animals was evaluated by the number of fecal boluses. After the initial (control) tests, the rats were divided into three subgroups based on the severity of depression as determined in the Porsolt test. Alcoholism was modeled by intraperitoneal injections of 10% ethanol (2 g/kg body weight) for 14 days. Then the animal behavior was re-tested. Sulpiride (Eglonyl, Sanofi Winthrop Industrie, France) was administered for 14 days at a dose of 10 mg/kg, intraperitoneally; then the animals were tested again. Results. Two-week alcoholization resulted in increased anxiety and depression of rats with low and medium depression degree at baseline. These disorders were evident from shortened stay of these animals in the open space of elevated plus-maze, reduced number of repeated exits from the open space, and a significant increase in the total time of immobility in the Porsolt test. The subsequent sulpiride treatment corrected the anxiogenic and depressogenic effects of alcoholism in male rats of these subgroups. Originally high-depressive animals did not show a sensitivity to the 14 day-administration of ethanol and subsequent inhibition of D2/D3-dopamine receptors in the elevated plus-maze and Porsolt test. Administration of ethanol for 14 days suppressed both the exploratory activity of rats in the open field regardless of their baseline degree of depression, and the locomotor activity of low-depressive animals. The subsequent sulpiride treatment did not abolish the effect of alcohol on the behavioral activity in the open field. Low-depressive alcoholized males developed a depression-like condition characterized by a marked behavioral deficit in the open field. The two-week alcoholization resulted in a significant (2-3.5 times) increase in the emotionality irrespective of the baseline degree of depression. This disorder was fully corrected by the sulpiride treatment in high-depressive rats and partially reduced the signs of emotionality in low- and medium-depressive animals. Conclusion. The study showed a possibility for correction of anxiety and depressive disorders induced by two weeks of modeled alcohol abuse with sulpiride depending on individual typological features of animals.

scholarly journals Chronic unpredictable stress regulates visceral adipocyte-mediated glucose metabolism and inflammatory circuits in male rats

2014 ◽  
Vol 2 (5) ◽  
pp. e00284 ◽  
Author(s):  
Iordanes Karagiannides ◽  
Viktoriya Golovatscka ◽  
Kyriaki Bakirtzi ◽  
Aristea Sideri ◽  
Martha Salas ◽  
...  
Keyword(s):  
Glucose Metabolism ◽  
Male Rats ◽  
Chronic Unpredictable Stress

scholarly journals The biochemical estimation of the nitric oxide system in prenatally stressed rats

2021 ◽  
Vol 20 (3) ◽  
pp. 61-69
Author(s):  
L. E. Belyaeva ◽  
H. N. Pauliukevich
Keyword(s):  
Nitric Oxide ◽  
Blood Serum ◽  
Oxide System ◽  
No Synthase ◽  
Female Rats ◽  
Male Rats ◽  
Nitric Oxide Synthesis ◽  
Chronic Unpredictable Stress ◽  
Prenatally Stressed ◽  
Nitric Oxide System

Introduction. Pregnancy development following unfavorable conditions could facilitate disorders of nitric oxide (NO) production during offspring’s postnatal life and «program» offspring’s cardiovascular diseases. Investigation of particular features and mechanisms of nitric oxide synthesis and action disorders following prenatal stress will promote expansion of considerations about pathogenesis of different cardiovascular diseases and propose new approaches to their prevention and management.The aim of the investigation is to assess the nature of nitric oxide synthesis and action in mature rats whose mothers were exposed to chronic «unpredictable» stress during pregnancy. Materials and methods. Pregnant rats were subdivided into the «control» and «stress» groups (in 20 animals). The rats from the «stress» group were exposed to multiple different stressors at various intervals, such as 1-day famine; 20-min. immobilization in the water at room temperature; 1-day contact with cats’ excrements. In the blood serum of 3-mo offspring (n=96, including «control» males – 24, «control» females – 26, «stress» males – 22, «stress» females – 24) concentration of the stable products of NO degradation – nitrates/nitrites (NO3–/NO2–), endothelial (eNOS) and inducible (iNOS) isoforms of the NO-synthase, inhibitor of NO-synthase asymmetric dimethylargininne (ADMA), cyclic guanosine monophosphate (cGMP), lipid peroxidation products – diene conjugates (DC) and malonic dialdehyde (MDA) and C-reactive protein (hsCRP) was detected. Results. The decrease of eNOS and cGMP concentration (by 12.9 and 31.9 %, respectively), increase of iNOS, hsCRP and ADMA concentration (by 49.9, 20.3 и 63.1 %, respectively) without statistically significant fluctuation in the NO3–/NO2– level and accumulation of DC and MDA by 21.1 % and 1.5 times in a prenatally stressed male rats’ blood serum were found (as compared with «control» male rats). In a blood serum of female rats, whose mothers were exposed to chronic «unpredictable» stress during pregnancy, a tendency to eNOS concentration decreasing, and increase of iNOS by 30.6 %, hsCRP by 23.9 % and MDA by 2.3 times without statistically significant changes in cGMP, ADMA, NO3–/NO2–, and DC concentration were detected (as compared with «control» female rats). Conclusion. Identified changes of the nitric oxide system synthesis and action in the prenatally stressed male rats could argue the high risk of their cardiovascular system lesion.

scholarly journals Chronic unpredictable stress inhibits nociception in male rats

2004 ◽  
Vol 359 (1-2) ◽  
pp. 73-76 ◽  
Author(s):  
Filipa Pinto-Ribeiro ◽  
Armando Almeida ◽  
José M. Pêgo ◽  
João Cerqueira ◽  
Nuno Sousa
Keyword(s):  
Male Rats ◽  
Chronic Unpredictable Stress

The effects of chronic unpredictable stress on male rats in the water maze

2005 ◽  
Vol 86 (1-2) ◽  
pp. 21-31 ◽  
Author(s):  
Angela M. Gouirand ◽  
Leslie Matuszewich
Keyword(s):  
Water Maze ◽  
Male Rats ◽  
Chronic Unpredictable Stress
Sign in / Sign up

Export Citation Format

Share Document