The effects of chronic unpredictable stress on male rats in the water maze

2005 ◽  
Vol 86 (1-2) ◽  
pp. 21-31 ◽  
Author(s):  
Angela M. Gouirand ◽  
Leslie Matuszewich
Keyword(s):  
Water Maze ◽  
Male Rats ◽  
Chronic Unpredictable Stress

scholarly journals Beneficial effect of retigabine on memory in rats receiving ethanol

2020 ◽  
Author(s):  
Ewa Zwierzyńska ◽  
Agata Krupa-Burtnik ◽  
Bogusława Pietrzak
Keyword(s):  
Beneficial Effect ◽  
Fear Conditioning ◽  
Morris Water Maze ◽  
Water Maze ◽  
Experimental Models ◽  
Male Rats ◽  
Ethanol Administration ◽  
Free Access ◽  
Oral Gavage ◽  
The Impact

Abstract Background Retigabine belongs to the novel generation of antiepileptic drugs but its complex mechanism of action causes that the drug might be effective in other diseases, for instance, alcohol dependence. It is known that ethanol abuse impaired the function of brain structures associated with memory and learning such as the hippocampus. In our previous study, retigabine reduced hippocampal changes induced by ethanol in the EEG rhythms in rabbits. This study is focused on the impact of retigabine on memory processes in male rats receiving alcohol. Methods Memory was evaluated in various experimental models: Morris water maze, Contextual, and Cued Fear Conditioning tests. Retigabine was administered for 3 weeks directly to the stomach via oral gavage at a dose of 10 mg/kg. Rats received also 20% ethanol (5 g/kg/day in two doses) via oral gavage for 3 weeks and had free access to 5% ethanol in the afternoon and at night. Morris water maze was performed after 1 and 3 weeks of ethanol administration and after 1 week from the discontinuation of ethanol administration. Contextual and Cued Fear Conditioning tests were carried out after 24 h and 72 h of alcohol discontinuation. Results The drug significantly decreased ethanol-induced memory disturbances during alcohol administration as well as slightly improved learning processes after the discontinuation of ethanol administration. Conclusions This beneficial effect of retigabine-ethanol interaction on memory may be a relevant element of the drug’s impact on the development of addiction.

The timing of maternal separation affects morris water maze performance and long-term potentiation in male rats

2013 ◽  
Vol 56 (5) ◽  
pp. 1102-1109 ◽  
Author(s):  
Xiujing Cao ◽  
Shenghai Huang ◽  
Jiejie Cao ◽  
Tingting Chen ◽  
Ping Zhu ◽  
...  
Keyword(s):  
Morris Water Maze ◽  
Water Maze ◽  
Maternal Separation ◽  
Long Term Potentiation ◽  
Male Rats ◽  
Maze Performance ◽  
Term Potentiation

scholarly journals Effect of Voluntary Exercise Training on Corticosterone Level and Immobility Behavior Induced by Chronic Stress in Rats

2020 ◽  
Vol 6 (3) ◽  
pp. 164-169
Author(s):  
Zahra Entezari ◽  
◽  
Ayyub Babaei ◽  
Saleh Rahmati-Ahmadabad ◽  
◽  
...  
Keyword(s):  
Exercise Training ◽  
Chronic Stress ◽  
Exercise Group ◽  
Voluntary Exercise ◽  
Male Rats ◽  
Depression Symptoms ◽  
Chronic Unpredictable Stress ◽  
Corticosterone Concentration ◽  
Serum Corticosterone ◽  
Immobility Time

Background: Depression is a common mood disorder that in the long-term impairs thoughts, behavior, feelings, and health. Chronic unpredictable stress is one of the factors that can cause depression. Objectives: To investigate the effect of voluntary exercise training on immobility behavior (caused by chronic unpredictable stress) and serum corticosterone concentration. Materials & Methods: A total of 24 male rats were randomly and equally assigned to four groups of healthy-control, healthy-exercise, depressed-control, and depressed-exercise. Depressed-control and depressed-exercise groups were first exposed to three weeks of chronic unpredictable stress. After this period, the exercise groups performed four weeks of voluntary exercise training. Twentyfour hours after the last training session, a forced swim test was taken from the rats and their blood samples were taken 24 hours later. The obtained data were analyzed using a 2-way analysis of variance (significance level: P<0.05). The Pearson correlation coefficient was used to examine the relationship between study variables. All statistical analyses were performed in SPSS v. 22. Results: Chronic stress increased immobility behavior (P=0.001) and serum corticosterone concentration (P=0.001). In contrast, exercise training reduced immobility behavior (P=0.001) and serum corticosterone (P=0.001). The immobility time (P=0.001) and serum corticosterone concentration in the depressed-exercise group were higher than those in the healthy-exercise group (P=0.001). There was a positive correlation between immobility behavior and serum corticosterone concentration (r=0.85 and P=0.001). Conclusion: While the chronic stress increases the immobility behavior and serum corticosterone concentration, voluntary exercise training can reduce immobility behavior and serum corticosterone and adjust some depression symptoms.

Beta-hydroxy-beta-methylbutyrate (HMB) ameliorates age-related deficits in water maze performance, especially in male rats

2017 ◽  
Vol 170 ◽  
pp. 93-99 ◽  
Author(s):  
Daniel G. Kougias ◽  
Emily R. Hankosky ◽  
Joshua M. Gulley ◽  
Janice M. Juraska
Keyword(s):  
Water Maze ◽  
Male Rats ◽  
Maze Performance ◽  
Age Related

Effects of Saturated and Unsaturated Fats on Learning, Emotionality, and Reaction to Stress

1971 ◽  
Vol 29 (1) ◽  
pp. 79-86 ◽  
Author(s):  
B. Caffrey ◽  
M. Y. Patterson
Keyword(s):  
Pilot Study ◽  
Operant Conditioning ◽  
Dietary Fat ◽  
Water Maze ◽  
Saturated Fat ◽  
Male Rats ◽  
Escape Conditioning ◽  
Low Fat ◽  
Skinner Box

Dietary fat was manipulated in a pilot study to assess its effects on emotionality, operant conditioning, and escape conditioning in 30 male rats. Low-fat Ss learned best in the Skinner box. Those maintained on high saturated fat showed somewhat more emotionality but performed better in the water maze. There was some indication that restriction of dietary fat did not interfere with routine learning, but it did retard learning under stressful conditions.

Nandrolone decanoate administration elevates hippocampal prodynorphin mRNA expression and impairs Morris water maze performance in male rats

2009 ◽  
Vol 467 (3) ◽  
pp. 189-193 ◽  
Author(s):  
Kristina Magnusson ◽  
Anders Hånell ◽  
Igor Bazov ◽  
Fredrik Clausen ◽  
Qin Zhou ◽  
...  
Keyword(s):  
Mrna Expression ◽  
Morris Water Maze ◽  
Water Maze ◽  
Male Rats ◽  
Maze Performance ◽  
Nandrolone Decanoate ◽  
Prodynorphin Mrna

Testosterone has antidepressant-like efficacy and facilitates imipramine-induced neuroplasticity in male rats exposed to chronic unpredictable stress

2016 ◽  
Vol 79 ◽  
pp. 58-69 ◽  
Author(s):  
Steven R. Wainwright ◽  
Joanna L. Workman ◽  
Amir Tehrani ◽  
Dwayne K. Hamson ◽  
Carmen Chow ◽  
...  
Keyword(s):  
Male Rats ◽  
Chronic Unpredictable Stress

3α-diol administration decreases hippocampal PKA (II) mRNA expression and impairs Morris water maze performance in adult male rats

2015 ◽  
Vol 280 ◽  
pp. 149-159 ◽  
Author(s):  
Somayeh Assadian Narenji ◽  
Nasser Naghdi ◽  
Kayhan Azadmanesh ◽  
Rosita Edalat
Keyword(s):  
Mrna Expression ◽  
Morris Water Maze ◽  
Adult Male ◽  
Water Maze ◽  
Male Rats ◽  
Maze Performance

scholarly journals Chronic unpredictable stress regulates visceral adipocyte-mediated glucose metabolism and inflammatory circuits in male rats

2014 ◽  
Vol 2 (5) ◽  
pp. e00284 ◽  
Author(s):  
Iordanes Karagiannides ◽  
Viktoriya Golovatscka ◽  
Kyriaki Bakirtzi ◽  
Aristea Sideri ◽  
Martha Salas ◽  
...  
Keyword(s):  
Glucose Metabolism ◽  
Male Rats ◽  
Chronic Unpredictable Stress
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