scholarly journals Chronic unpredictable stress inhibits nociception in male rats

2004 ◽  
Vol 359 (1-2) ◽  
pp. 73-76 ◽  
Author(s):  
Filipa Pinto-Ribeiro ◽  
Armando Almeida ◽  
José M. Pêgo ◽  
João Cerqueira ◽  
Nuno Sousa
Keyword(s):  
Male Rats ◽  
Chronic Unpredictable Stress

scholarly journals Effect of Voluntary Exercise Training on Corticosterone Level and Immobility Behavior Induced by Chronic Stress in Rats

2020 ◽  
Vol 6 (3) ◽  
pp. 164-169
Author(s):  
Zahra Entezari ◽  
◽  
Ayyub Babaei ◽  
Saleh Rahmati-Ahmadabad ◽  
◽  
...  
Keyword(s):  
Exercise Training ◽  
Chronic Stress ◽  
Exercise Group ◽  
Voluntary Exercise ◽  
Male Rats ◽  
Depression Symptoms ◽  
Chronic Unpredictable Stress ◽  
Corticosterone Concentration ◽  
Serum Corticosterone ◽  
Immobility Time

Background: Depression is a common mood disorder that in the long-term impairs thoughts, behavior, feelings, and health. Chronic unpredictable stress is one of the factors that can cause depression. Objectives: To investigate the effect of voluntary exercise training on immobility behavior (caused by chronic unpredictable stress) and serum corticosterone concentration. Materials & Methods: A total of 24 male rats were randomly and equally assigned to four groups of healthy-control, healthy-exercise, depressed-control, and depressed-exercise. Depressed-control and depressed-exercise groups were first exposed to three weeks of chronic unpredictable stress. After this period, the exercise groups performed four weeks of voluntary exercise training. Twentyfour hours after the last training session, a forced swim test was taken from the rats and their blood samples were taken 24 hours later. The obtained data were analyzed using a 2-way analysis of variance (significance level: P<0.05). The Pearson correlation coefficient was used to examine the relationship between study variables. All statistical analyses were performed in SPSS v. 22. Results: Chronic stress increased immobility behavior (P=0.001) and serum corticosterone concentration (P=0.001). In contrast, exercise training reduced immobility behavior (P=0.001) and serum corticosterone (P=0.001). The immobility time (P=0.001) and serum corticosterone concentration in the depressed-exercise group were higher than those in the healthy-exercise group (P=0.001). There was a positive correlation between immobility behavior and serum corticosterone concentration (r=0.85 and P=0.001). Conclusion: While the chronic stress increases the immobility behavior and serum corticosterone concentration, voluntary exercise training can reduce immobility behavior and serum corticosterone and adjust some depression symptoms.

Testosterone has antidepressant-like efficacy and facilitates imipramine-induced neuroplasticity in male rats exposed to chronic unpredictable stress

2016 ◽  
Vol 79 ◽  
pp. 58-69 ◽  
Author(s):  
Steven R. Wainwright ◽  
Joanna L. Workman ◽  
Amir Tehrani ◽  
Dwayne K. Hamson ◽  
Carmen Chow ◽  
...  
Keyword(s):  
Male Rats ◽  
Chronic Unpredictable Stress

scholarly journals Chronic unpredictable stress regulates visceral adipocyte-mediated glucose metabolism and inflammatory circuits in male rats

2014 ◽  
Vol 2 (5) ◽  
pp. e00284 ◽  
Author(s):  
Iordanes Karagiannides ◽  
Viktoriya Golovatscka ◽  
Kyriaki Bakirtzi ◽  
Aristea Sideri ◽  
Martha Salas ◽  
...  
Keyword(s):  
Glucose Metabolism ◽  
Male Rats ◽  
Chronic Unpredictable Stress

scholarly journals The biochemical estimation of the nitric oxide system in prenatally stressed rats

2021 ◽  
Vol 20 (3) ◽  
pp. 61-69
Author(s):  
L. E. Belyaeva ◽  
H. N. Pauliukevich
Keyword(s):  
Nitric Oxide ◽  
Blood Serum ◽  
Oxide System ◽  
No Synthase ◽  
Female Rats ◽  
Male Rats ◽  
Nitric Oxide Synthesis ◽  
Chronic Unpredictable Stress ◽  
Prenatally Stressed ◽  
Nitric Oxide System

Introduction. Pregnancy development following unfavorable conditions could facilitate disorders of nitric oxide (NO) production during offspring’s postnatal life and «program» offspring’s cardiovascular diseases. Investigation of particular features and mechanisms of nitric oxide synthesis and action disorders following prenatal stress will promote expansion of considerations about pathogenesis of different cardiovascular diseases and propose new approaches to their prevention and management.The aim of the investigation is to assess the nature of nitric oxide synthesis and action in mature rats whose mothers were exposed to chronic «unpredictable» stress during pregnancy. Materials and methods. Pregnant rats were subdivided into the «control» and «stress» groups (in 20 animals). The rats from the «stress» group were exposed to multiple different stressors at various intervals, such as 1-day famine; 20-min. immobilization in the water at room temperature; 1-day contact with cats’ excrements. In the blood serum of 3-mo offspring (n=96, including «control» males – 24, «control» females – 26, «stress» males – 22, «stress» females – 24) concentration of the stable products of NO degradation – nitrates/nitrites (NO3–/NO2–), endothelial (eNOS) and inducible (iNOS) isoforms of the NO-synthase, inhibitor of NO-synthase asymmetric dimethylargininne (ADMA), cyclic guanosine monophosphate (cGMP), lipid peroxidation products – diene conjugates (DC) and malonic dialdehyde (MDA) and C-reactive protein (hsCRP) was detected. Results. The decrease of eNOS and cGMP concentration (by 12.9 and 31.9 %, respectively), increase of iNOS, hsCRP and ADMA concentration (by 49.9, 20.3 и 63.1 %, respectively) without statistically significant fluctuation in the NO3–/NO2– level and accumulation of DC and MDA by 21.1 % and 1.5 times in a prenatally stressed male rats’ blood serum were found (as compared with «control» male rats). In a blood serum of female rats, whose mothers were exposed to chronic «unpredictable» stress during pregnancy, a tendency to eNOS concentration decreasing, and increase of iNOS by 30.6 %, hsCRP by 23.9 % and MDA by 2.3 times without statistically significant changes in cGMP, ADMA, NO3–/NO2–, and DC concentration were detected (as compared with «control» female rats). Conclusion. Identified changes of the nitric oxide system synthesis and action in the prenatally stressed male rats could argue the high risk of their cardiovascular system lesion.

The effects of chronic unpredictable stress on male rats in the water maze

2005 ◽  
Vol 86 (1-2) ◽  
pp. 21-31 ◽  
Author(s):  
Angela M. Gouirand ◽  
Leslie Matuszewich
Keyword(s):  
Water Maze ◽  
Male Rats ◽  
Chronic Unpredictable Stress

scholarly journals Running exercise protects oligodendrocytes in the medial prefrontal cortex in chronic unpredictable stress rat model

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Yanmin Luo ◽  
Qian Xiao ◽  
Jin Wang ◽  
Lin Jiang ◽  
Menglan Hu ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Medial Prefrontal Cortex ◽  
Rat Model ◽  
Animal Studies ◽  
Treadmill Running ◽  
Male Rats ◽  
Structural Basis ◽  
Chronic Unpredictable Stress ◽  
Running Exercise ◽  
Beneficial Effects

AbstractPrevious postmortem and animal studies have shown decreases in the prefrontal cortex (PFC) volume and the number of glial cells in the PFC of depression. Running exercise has been shown to alleviate depressive symptoms. However, the effects of running exercise on the medial prefrontal cortex (mPFC) volume and oligodendrocytes in the mPFC of depressed patients and animals have not been investigated. To address these issues, adult male rats were subjected to chronic unpredictable stress (CUS) for 5 weeks, followed by treadmill running for 6 weeks. Then, the mPFC volume and the mPFC oligodendrocytes were investigated using stereology, immunohistochemistry, immunofluorescence and western blotting. Using a CUS paradigm that allowed for the analysis of anhedonia, we found that running exercise alleviated the deficits in sucrose preference, as well as the decrease in the mPFC volume. Meanwhile, we found that running exercise significantly increased the number of CNPase+ oligodendrocytes and Olig2+ oligodendrocytes, reduced the ratio between Olig2+/NG2+ oligodendrocytes and Olig2+ oligodendrocytes and increased myelin basic protein (MBP), CNPase and Olig2 protein expression in the mPFC of the CUS rat model. However, running exercise did not change NG2+ oligodendrocyte number in the mPFC in these rats. These results indicated that running exercise promoted the differentiation of oligodendrocytes and myelin-forming ability in the mPFC in the context of depression. These findings suggest that the beneficial effects of running exercise on mPFC volume and oligodendrocytes in mPFC might be an important structural basis for the antidepressant effects of running exercise.

scholarly journals Impact of ketamine on spontaneous coordinate activity and short memory behavior in rodents chronic unpredictable stress model

2021 ◽  
pp. 76-76
Author(s):  
Ana Starcevic ◽  
Darko Laketic ◽  
Ana Cirovic ◽  
Aleksandra Zelenovic ◽  
Jelena Boljanovic ◽  
...  
Keyword(s):  
Short Term Memory ◽  
Single Injection ◽  
Statistical Significance ◽  
Male Rats ◽  
Control Group ◽  
Chronic Unpredictable Stress ◽  
Short Term ◽  
Short Memory ◽  
The Impact ◽  
Experimental Group

Introduction/Objective. This research aims to evaluate the impact of chronic stress on behavioral effects of ketamine, which are not sufficiently clear, still. Methods. Wistar male rats aged five weeks were used in the experiment. The animals were divided into two equal groups: control and experimental. After being exposed to a chronic unpredictable stress paradigm for 42 days, experimental rats had received a single injection of ketamine (10 mg/kg; day 45) as well as control group. The impact of ketamine was assessed using behavioral tests, spontaneous coordinate activity, and water maze tests for the evaluation of short-term memory. Results. The experimental group rats showed less spontaneous motoric activity than before ketamine application. Statistical significance was shown in gaining weight after time of ketamine application in control group and also in experimental group where they showed weight loss during stress paradigm and then increased their weight after ketamine application. There was no statistical significance in speed measurements in both groups showing no effects on short memory behavior. Conclusion. These findings show that ketamine in single subanesthetic dose has antidepressant and anxiolytic like effects in male rats exposed to chronic unpredictable stress paradigm

Author response for "Mapping of the excitatory, inhibitory, and modulatory afferent projections to the anatomically defined active expiratory oscillator in adult male rats"

2020 ◽  
Author(s):  
Vivian Biancardi ◽  
Jashan Saini ◽  
Anileen Pageni ◽  
M. Hema Prashaad ◽  
Gregory D. Funk ◽  
...  
Keyword(s):  
Adult Male ◽  
Male Rats ◽  
Author Response ◽  
Afferent Projections
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