Effect of painless rectal distension on gastrointestinal transit of solid meal

1984 ◽  
Vol 29 (10) ◽  
pp. 902-906 ◽  
Author(s):  
M. S. Youle ◽  
N. W. Read
Keyword(s):  
Gastrointestinal Transit ◽  
Rectal Distension ◽  
Solid Meal

scholarly journals Effect of cisapride on the gastrointestinal transit of a solid meal in normal human subjects.

Gut ◽  
1987 ◽  
Vol 28 (1) ◽  
pp. 13-16 ◽  
Author(s):  
C A Edwards ◽  
S Holden ◽  
C Brown ◽  
N W Read
Keyword(s):  
Human Subjects ◽  
Gastrointestinal Transit ◽  
Solid Meal ◽  
Normal Human

Effects of Morphine and Tramadol on Somatic and Visceral Sensory Function and Gastrointestinal Motility after Abdominal Surgery 

1999 ◽  
Vol 91 (3) ◽  
pp. 639-639 ◽  
Author(s):  
Clive H. Wilder-Smith ◽  
Lauren Hill ◽  
Justin Wilkins ◽  
Lynnette Denny
Keyword(s):  
Gastrointestinal Motility ◽  
Gastrointestinal Transit ◽  
Colonic Transit ◽  
Pain Tolerance ◽  
Sensory Function ◽  
Rectal Distension ◽  
Gut Motility ◽  
Before And After ◽  
Sensory Parameters ◽  
Double Blinded

Background Chronic nociceptive input induces sensitization and changes in regulatory reflexes in animal models. In humans, postoperative somatic and visceral sensitization and the secondary effects on reflex gut motility are unclear. Methods Somatic and visceral sensation and gastrointestinal motility were evaluated after abdominal hysterectomies in 50 patients who were randomized to receive double-blinded postoperative 48-h infusions of morphine or tramadol. Pain scores, rectal distension, skin electric sensation and pain tolerance thresholds, and gastrointestinal transit were assessed before and after operation, during and after analgesic infusions. Results Pain intensity scores decreased similarly with morphine and tramadol infusions (total doses, 66.8+/-20 mg and 732.4+/-152 mg [mean +/- SD], respectively). Skin pain tolerance thresholds in the incisional dermatome remained similar with morphine and tramadol throughout the study. During morphine infusions, pain tolerance thresholds on the shoulder increased (P<0.05) and then decreased after discontinuation on day 4 (P<0.02) compared with before operation. Rectal distension pain tolerance pressure thresholds increased after operation during morphine infusions (P<0.05). Similar but nonsignificant trends occurred with tramadol. Orocecal and colonic transit times increased after operation with both morphine and tramadol (P<0.005), but gastric emptying was prolonged only with morphine (P = 0.03). AU motility and sensory parameters had returned to preoperative levels by 1 month after operation. Conclusions Pain control was equally effective with morphine and tramadol infusions. No somatic or visceral sensitization was evident during morphine and tramadol infusions, but pain tolerance thresholds as markers of antinociception were increased more during morphine infusions. The significant sensitization seen only after morphine discontinuation may be due to convergent visceral input. Gut motility was prolonged significantly by visceral surgery itself and also by morphine.

Cerebral cortical response to rectal distension varies with phases of the menstrual cycle

2001 ◽  
Vol 120 (5) ◽  
pp. A397-A397
Author(s):  
M KERN ◽  
R ARNDORFER ◽  
R COX ◽  
J HYDE ◽  
R SHAKER
Keyword(s):  
Menstrual Cycle ◽  
Cortical Response ◽  
Rectal Distension

An easy and low-cost biomagnetic methodology to study regional gastrointestinal transit in rats

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Leonardo Pinto ◽  
Guilherme Soares ◽  
André Próspero ◽  
Erick Stoppa ◽  
Gabriel Biasotti ◽  
...  
Keyword(s):  
Low Cost ◽  
Gastrointestinal Transit ◽  
Alternate Current ◽  
Phenol Red ◽  
Distal Small Intestine ◽  
Reliable Assessment ◽  
Imaging Approach ◽  
Magnetic Tracer ◽  
Tracer Distribution ◽  
Gi Transit

Abstract The identification of gastrointestinal (GI) motility disorders requires the evaluation of regional GI transit, and the development of alternative methodologies in animals has a significant impact on translational approaches. Therefore, the purpose of this study was to validate an easy and low-cost methodology (alternate current biosusceptometry – ACB) for the assessment of regional GI transit in rats through images. Rats were fed a test meal containing magnetic tracer and phenol red, and GI segments (stomach, proximal, medial and distal small intestine, and cecum) were collected to assess tracer’s retention at distinct times after ingestion (0, 60, 120, 240, and 360 min). Images were obtained by scanning the segments, and phenol red concentration was determined by the sample’s absorbance. The temporal retention profile, geometric center, gastric emptying, and cecum arrival were evaluated. The correlation coefficient between methods was 0.802, and the temporal retention of each segment was successfully assessed. GI parameters yielded comparable results between methods, and ACB images presented advantages as the possibility to visualize intrasegmental tracer distribution and the automated scan of the segments. The imaging approach provided a reliable assessment of several parameters simultaneously and may serve as an accurate and sensitive approach for regional GI research in rats.

scholarly journals “Masato de Yuca” and “Chicha de Siete Semillas” Two Traditional Vegetable Fermented Beverages from Peru as Source for the Isolation of Potential Probiotic Bacteria

2021 ◽  
Author(s):  
Teresa D. Rebaza-Cardenas ◽  
Kenneth Silva-Cajaleón ◽  
Carlos Sabater ◽  
Susana Delgado ◽  
Nilda D. Montes-Villanueva ◽  
...  
Keyword(s):  
Gastrointestinal Transit ◽  
Probiotic Strain ◽  
In Vitro Digestion ◽  
Intestinal Cell ◽  
Adhesion Ability ◽  
Intestinal Cell Line ◽  
Carbohydrate Fermentation ◽  
Traditional Vegetable ◽  
Genetic Profiles

AbstractIn this work, two Peruvian beverages “Masato de Yuca,” typical of the Amazonian communities made from cassava (Manihot esculenta), and “Chicha de Siete Semillas,” made from different cereal, pseudo-cereal, and legume flours, were explored for the isolation of lactic acid bacteria after obtaining the permission of local authorities following Nagoya protocol. From an initial number of 33 isolates, 16 strains with different RAPD- and REP-PCR genetic profiles were obtained. In Chicha, all strains were Lactiplantibacillus plantarum (formerly Lactobacillus plantarum), whereas in Masato, in addition to this species, Limosilactobacillus fermentum (formerly Lactobacillus fermentum), Pediococcus acidilactici, and Weissella confusa were also identified. Correlation analysis carried out with their carbohydrate fermentation patterns and enzymatic profiles allowed a clustering of the lactobacilli separated from the other genera. Finally, the 16 strains were submitted to a static in vitro digestion (INFOGEST model) that simulated the gastrointestinal transit. Besides, their ability to adhere to the human epithelial intestinal cell line HT29 was also determined. Following both procedures, the best probiotic candidate was Lac. plantarum Ch13, a robust strain able to better face the challenging conditions of the gastrointestinal tract and showing higher adhesion ability to the intestinal epithelium in comparison with the commercial probiotic strain 299v. In order to characterize its benefit for human health, this Ch13 strain will be deeply studied in further works.

scholarly journals Identification and Transferability of Tetracycline Resistance in Streptococcus thermophilus during Milk Fermentation, Storage, and Gastrointestinal Transit

Fermentation ◽  
2021 ◽  
Vol 7 (2) ◽  
pp. 65
Author(s):  
Armin Tarrah ◽  
Shadi Pakroo ◽  
Viviana Corich ◽  
Alessio Giacomini
Keyword(s):  
Efflux Pump ◽  
Acquired Resistance ◽  
Gastrointestinal Transit ◽  
Tetracycline Resistance ◽  
Lactobacillus Delbrueckii ◽  
Genomic Islands ◽  
Resistant Bacteria ◽  
Human Pathogens ◽  
Resistance Level ◽  
Milk Fermentation

The existence of antibiotic-resistant bacteria in food products, particularly those carrying acquired resistance genes, has increased concerns about the transmission of these genes from beneficial microbes to human pathogens. In this study, we evaluated the antibiotic resistance-susceptibility patterns of 16 antibiotics in eight S. thermophilus strains, whose genome sequence is available, using phenotypic and genomic approaches. The minimal inhibitory concentration values collected revealed intermediate resistance to aminoglycosides, whereas susceptibility was detected for different classes of β-lactams, quinolones, glycopeptide, macrolides, and sulfonamides in all strains. A high tetracycline resistance level has been detected in strain M17PTZA496, whose genome analysis indicated the presence of the tet(S) gene and the multidrug and toxic compound extrusion (MATE) family efflux pump. Moreover, an in-depth genomic analysis revealed genomic islands and an integrative and mobilizable element (IME) in the proximity of the gene tet(S). However, despite the presence of a prophage, genomic islands, and IME, no horizontal gene transfer was detected to Lactobacillus delbrueckii subsp. lactis DSM 20355 and Lactobacillusrhamnosus GG during 24 h of skim milk fermentation, 2 weeks of refrigerated storage, and 4 h of simulated gastrointestinal transit.

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