Selection of tumor cell variants for resistance to tumor necrosis factor also induces a form of pleiotropic drug resistance

1992 ◽  
Vol 34 (6) ◽  
pp. 399-406 ◽  
Author(s):  
Susan C. Wright ◽  
Albert W. Tam ◽  
Poornima Kumar
Keyword(s):  
Drug Resistance ◽  
Tumor Necrosis Factor ◽  
Tumor Cell ◽  
Tumor Necrosis ◽  
Pleiotropic Drug Resistance ◽  
Necrosis Factor ◽  
Selection Of

scholarly journals Selection of a Novel and Highly Specific Tumor Necrosis Factor α (TNFα) Antagonist

2010 ◽  
Vol 285 (16) ◽  
pp. 12096-12100 ◽  
Author(s):  
Povilas Byla ◽  
Mikkel H. Andersen ◽  
Thor L. Holtet ◽  
Helle Jacobsen ◽  
Mette Munch ◽  
...  
Keyword(s):  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Specific Tumor ◽  
Factor Α ◽  
Necrosis Factor ◽  
Selection Of

scholarly journals Mycobacterium bovis BCG promotes tumor cell survival from tumor necrosis factor-α-induced apoptosis

2014 ◽  
Vol 13 (1) ◽  
pp. 210 ◽  
Author(s):  
Sahana Holla ◽  
Devram Ghorpade ◽  
Vikas Singh ◽  
Kushagra Bansal ◽  
Kithiganahalli Balaji
Keyword(s):  
Tumor Necrosis Factor ◽  
Tumor Cell ◽  
Cell Survival ◽  
Mycobacterium Bovis ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Tumor Cell Survival ◽  
Induced Apoptosis ◽  
Factor Α ◽  
Necrosis Factor

scholarly journals APRIL, a New Ligand of the Tumor Necrosis Factor Family, Stimulates Tumor Cell Growth

1998 ◽  
Vol 188 (6) ◽  
pp. 1185-1190 ◽  
Author(s):  
Michael Hahne ◽  
Takao Kataoka ◽  
Michael Schröter ◽  
Kay Hofmann ◽  
Martin Irmler ◽  
...  
Keyword(s):  
Cell Growth ◽  
Tumor Necrosis Factor ◽  
Tumor Cell ◽  
Tumor Necrosis ◽  
Parental Cell Line ◽  
Lymphoid Tissues ◽  
Tumor Cell Growth ◽  
Transformed Cell Lines ◽  
Necrosis Factor

Members of the tumor necrosis factor (TNF) family induce pleiotropic biological responses, including cell growth, differentiation, and even death. Here we describe a novel member of the TNF family designated APRIL (for a proliferation-inducing ligand). Although transcripts of APRIL are of low abundance in normal tissues, high levels of mRNA are detected in transformed cell lines, and in human cancers of colon, thyroid, and lymphoid tissues in vivo. The addition of recombinant APRIL to various tumor cells stimulates their proliferation. Moreover, APRIL-transfected NIH-3T3 cells show an increased rate of tumor growth in nude mice compared with the parental cell line. These findings suggest that APRIL may be implicated in the regulation of tumor cell growth.

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