Correlation between ultrastructural and functional changes in sarcoplasmic reticulum during chronic stimulation of fast muscle

1981 ◽  
Vol 59 (2) ◽  
pp. 143-149 ◽  
Author(s):  
Claus Heilmann ◽  
Werner Müller ◽  
Dirk Pette
Keyword(s):  
Sarcoplasmic Reticulum ◽  
Fast Muscle ◽  
Chronic Stimulation ◽  
Functional Changes ◽  
Stimulation Of

scholarly journals Ca-ATPase isozyme expression in sarcoplasmic reticulum is altered by chronic stimulation of skeletal muscle

FEBS Letters ◽  
1990 ◽  
Vol 259 (2) ◽  
pp. 269-272 ◽  
Author(s):  
F.Norman Briggs ◽  
K.Francis Lee ◽  
Joseph J. Feher ◽  
Andrew S. Wechsler ◽  
Kay Ohiendieck ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Sarcoplasmic Reticulum ◽  
Chronic Stimulation ◽  
Stimulation Of

Deep brain stimulation modulates hypothalamic-brainstem fibers in cluster headache: case report

2020 ◽  
Vol 132 (3) ◽  
pp. 717-720 ◽  
Author(s):  
Sérgio A. F. Dantas ◽  
Eduardo J. L. Alho ◽  
Juliano J. da Silva ◽  
Nilson N. Mendes Neto ◽  
Erich Talamoni Fonoff ◽  
...  
Keyword(s):  
Deep Brain Stimulation ◽  
Cluster Headache ◽  
Brain Stimulation ◽  
Clinical Effects ◽  
Chronic Stimulation ◽  
Mammillary Bodies ◽  
Fiber Tracts ◽  
White Matter Region ◽  
Deep Brain ◽  
Stimulation Of

Hypothalamic deep brain stimulation (DBS) has been used for more than a decade to treat cluster headache (CH) but its mechanisms remain poorly understood. The authors have successfully treated a patient with CH using hypothalamic DBS and found that the contact used for chronic stimulation was located in a white matter region posterior to the mammillary bodies. Fiber tracts crossing that region were the medial forebrain bundle and those interconnecting the hypothalamus and brainstem, including the dorsal longitudinal fasciculus. Because the stimulation of axons is an important mechanism of DBS, some of its clinical effects in CH may be related to the stimulation of fibers interconnecting the hypothalamus and brainstem.

scholarly journals Antigen-driven EGR2 expression is required for exhausted CD8+ T cell stability and maintenance

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Mayura V. Wagle ◽  
Stephin J. Vervoort ◽  
Madison J. Kelly ◽  
Willem Van Der Byl ◽  
Timothy J. Peters ◽  
...  
Keyword(s):  
T Cells ◽  
Transcription Factor ◽  
Cd8 T Cell ◽  
Chronic Stimulation ◽  
Epigenetic State ◽  
Multiple Differentiation ◽  
Cell Stability ◽  
Substantial Interest ◽  
Transcriptional State ◽  
Stimulation Of

AbstractChronic stimulation of CD8+ T cells triggers exhaustion, a distinct differentiation state with diminished effector function. Exhausted cells exist in multiple differentiation states, from stem-like progenitors that are the key mediators of the response to checkpoint blockade, through to terminally exhausted cells. Due to its clinical relevance, there is substantial interest in defining the pathways that control differentiation and maintenance of these subsets. Here, we show that chronic antigen induces the anergy-associated transcription factor EGR2 selectively within progenitor exhausted cells in both chronic LCMV and tumours. EGR2 enables terminal exhaustion and stabilizes the exhausted transcriptional state by both direct EGR2-dependent control of key exhaustion-associated genes, and indirect maintenance of the exhausted epigenetic state. We show that EGR2 is a regulator of exhaustion that epigenetically and transcriptionally maintains the differentiation competency of progenitor exhausted cells.

Dyskinesias and grip control in Parkinson's disease are normalized by chronic stimulation of the subthalamic nucleus

2002 ◽  
Vol 52 (2) ◽  
pp. 240-243 ◽  
Author(s):  
Roland Wenzelburger ◽  
Bao-Rong Zhang ◽  
Meike Poepping ◽  
Bettina Schrader ◽  
Dieter Müller ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Subthalamic Nucleus ◽  
Chronic Stimulation ◽  
Stimulation Of
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