Plasma lipid concentration and lipoprotein distribution in exercising and nonexercising rats fed a high sucrose diet

AbstractMetabolism influences locomotor behaviors, but the understanding of neural curcuit control for that is limited. Under standard light-dark cycles, Drosophila exhibits bimodal morning (M) and evening (E) locomotor activities that are controlled by clock neurons. Here, we showed that a high-nutrient diet progressively extended M activity but not E activity. Drosophila tachykinin (DTk) and Tachykinin-like receptor at 86C (TkR86C)-mediated signaling was required for the extension of M activity. DTk neurons were anatomically and functionally connected to the posterior dorsal neuron 1s (DN1ps) in the clock neuronal network. The activation of DTk neurons reduced intracellular Ca2+ levels in DN1ps suggesting an inhibitory connection. The contacts between DN1ps and DTk neurons increased gradually over time in flies fed a high-sucrose diet, consistent with the locomotor behavior. DN1ps have been implicated in integrating environmental sensory inputs (e.g., light and temperature) to control daily locomotor behavior. This study revealed that DN1ps also coordinated nutrient information through DTk signaling to shape daily locomotor behavior.

Download Full-text

High sucrose diet induces morphological, structural and functional impairments in the renal tubules of Drosophila melanogaster: A model for studying type-2 diabetes mediated renal tubular dysfunction

Insect Biochemistry and Molecular Biology ◽

10.1016/j.ibmb.2020.103441 ◽

2020 ◽

Vol 125 ◽

pp. 103441

Author(s):

Lavi Rani ◽

Sanjay Saini ◽

Neha Shukla ◽

Debapratim Kar Chowdhuri ◽

Naveen Kumar Gautam

Keyword(s):

Type 2 Diabetes ◽

Tubular Dysfunction ◽

Renal Tubular Dysfunction ◽

Renal Tubules ◽

Functional Impairments ◽

Sucrose Diet ◽

High Sucrose Diet ◽

Renal Tubular ◽

High Sucrose

Download Full-text

Puerarin protects against high‐fat high‐sucrose diet‐induced non‐alcoholic fatty liver disease by modulating PARP‐1/PI3K/AKT signaling pathway and facilitating mitochondrial homeostasis

Phytotherapy Research ◽

10.1002/ptr.6417 ◽

2019 ◽

Vol 33 (9) ◽

pp. 2347-2359 ◽

Cited By ~ 15

Author(s):

Shuai Wang ◽

Fa‐Ji Yang ◽

Long‐Cheng Shang ◽

Yu‐Heng Zhang ◽

Yuan Zhou ◽

...

Keyword(s):

Fatty Liver Disease ◽

Akt Signaling Pathway ◽

High Fat ◽

Alcoholic Fatty Liver ◽

Mitochondrial Homeostasis ◽

Sucrose Diet ◽

High Sucrose Diet ◽

Parp 1 ◽

High Sucrose ◽

Alcoholic Fatty Liver Disease

Download Full-text

Effects on Serum Lipids of Different Dietary Fats Associated with a High Sucrose Diet

Clinical Science ◽

10.1042/cs0440601 ◽

1973 ◽

Vol 44 (6) ◽

pp. 601-604 ◽

Cited By ~ 5

Author(s):

J. I. Mann ◽

G. S. Watermeyer ◽

E. B. Manning ◽

J. Randles ◽

A. S. Truswell

Keyword(s):

Serum Lipids ◽

Saturated Fat ◽

Dietary Fats ◽

Complex Carbohydrate ◽

The Third ◽

Sucrose Diet ◽

Daily Energy ◽

Dietary Period ◽

High Sucrose Diet ◽

High Sucrose

1. Each of nine volunteers was fed three different diets. The percentage of total daily energy provided by fat, carbohydrate and protein remained constant, but the nature of the fat and carbohydrate was altered. The first diet contained ordinary amounts of sucrose and predominantly saturated fat. During the second dietary period, fat remained saturated, but the quantity of sucrose was increased at the expense of complex carbohydrate. In the third dietary period, the sucrose intake remained high, but fat was supplied chiefly in the polyunsaturated form. 2. A small but statistically significant increase of serum fasting cholesterol and triglyceride was observed during the second dietary period, but on the third diet levels of both lipids fell to concentrations not significantly different from those seen on the first diet.

Download Full-text