I/D polymorphism at the locus for ACE and apo A-I gene promoter polymorphism as risk factors for coronary artery disease in patients with familial hypercholesterolemia

1996 ◽  
Vol 431 (S6) ◽  
pp. R197-R198 ◽  
Author(s):  
D. Petrovič ◽  
I. Kleber ◽  
M. Zore ◽  
B. Peterlin
Keyword(s):  
Risk Factors ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Familial Hypercholesterolemia ◽  
Gene Promoter ◽  
Promoter Polymorphism ◽  
Artery Disease ◽  
I Gene ◽  
Gene Promoter Polymorphism

COX-2 GENE PROMOTER POLYMORPHISM AND CORONARY ARTERY DISEASE IN MIDDLE-AGED MEN: THE HELSINKI SUDDEN DEATH STUDY

2008 ◽  
Vol 9 (1) ◽  
pp. 102
Author(s):  
K.H. Huuskonen ◽  
T.A. Kunnas ◽  
M.M. Tanner ◽  
J. Mikkelsson ◽  
E. Ilveskoski ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Sudden Death ◽  
Gene Promoter ◽  
Promoter Polymorphism ◽  
Middle Aged ◽  
Cox 2 ◽  
Artery Disease ◽  
Gene Promoter Polymorphism

scholarly journals HMOX1 Gene Promoter Polymorphism is Not Associated with Coronary Artery Disease in Koreans

2014 ◽  
Vol 34 (5) ◽  
pp. 337-344 ◽  
Author(s):  
Seong Woo Han ◽  
Wonkeun Song ◽  
Han-Sung Kim ◽  
Kyu-Sung Shin ◽  
Heejung Kang ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Gene Promoter ◽  
Promoter Polymorphism ◽  
Artery Disease ◽  
Gene Promoter Polymorphism

scholarly journals COX-2 Gene Promoter Polymorphism and Coronary Artery Disease in Middle-Aged Men: The Helsinki Sudden Death Study

2008 ◽  
Vol 2008 ◽  
pp. 1-5 ◽  
Author(s):  
Kati H. Huuskonen ◽  
Tarja A. Kunnas ◽  
Minna M. Tanner ◽  
Jussi Mikkelsson ◽  
Erkki Ilveskoski ◽  
...  
Keyword(s):  
Coronary Artery ◽  
Sudden Death ◽  
Coronary Arteries ◽  
Gene Promoter ◽  
Restriction Endonuclease Analysis ◽  
Promoter Polymorphism ◽  
Atherosclerotic Lesions ◽  
Cox 2 ◽  
Artery Disease ◽  
Gene Promoter Polymorphism

Cyclooxygenase (COX) catalyzes formation of prostaglandins that contribute to the inflammation in atherosclerosis. Our objective was to study whether the functional C variant of the−765G→Cpolymorphism in the human COX-2 gene associates with the severity of coronary atherosclerosis measured at the coronary artery level. The Helsinki sudden death study autopsy material (n= 300) comprised of Finnish men who died suddenly. The area of atherosclerotic lesions in the coronary arteries was quantitated, and coronary narrowing was measured. The occurrence of myocardial infarction (MI) was assessed. Genotyping was by restriction endonuclease analysis. Men carrying the minor C allele had larger areas of complicated lesions (P= .024) and a higher number of coronary arteries that had over 50% stenosis (P= .036) compared to men representing the common GG genotype. The COX-2 polymorphism was not associated with MI. Our data suggest that COX-2 may be involved in plaque growth.

Correlation of Coronary Artery Disease with Risk Factors on Computed Tomography Angiography

2021 ◽  
Vol 15 (8) ◽  
pp. 1795-1799
Author(s):  
Muhammad Zain Ul Abidin ◽  
Sarah Maryam ◽  
Hamid Khalil ◽  
S.Yousaf Farooq ◽  
Muhammad Zakir ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Computed Tomography ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Familial Hypercholesterolemia ◽  
Computed Tomography Angiography ◽  
Sampling Technique ◽  
Cross Sectional ◽  
Artery Disease

Background: Coronary Artery Disease (CAD) was the contraction of coronary arteries that was frequently began through the atherosclerosis which primes to restraint of blood flowing to cardiac muscles. Atherosclerosis was an accumulation of plaque or fats deposition upon the internal walls of arteries. Aim: To correlate coronary artery disease with risk factors on Computed Tomography Angiography. Duration and place of study: This study was conduct from 17-July-2019 to 13-Oct-2020 at Punjab Institute of Cardiology Lahore. Methods: A cross sectional analytical study was conducted at Punjab Institute of Cardiology, Lahore. Data were collected according to the age, gender and risk factors such as diabetes mellitus, hypertension, hyperlipidemia; high cholesterol level, contrast with volume, vessels involved and extent of vessels involvement.132 participants including 103 males (78%) and 29 females (22%) were selected through convenient sampling technique. Results: Data examination exhibited that out of 132 patients, 101 patients (76.5%) had CAD and 31 patients (23.5%) had no CAD. Out of 29 females, 21 female patients (20.8%) had CAD whereas out of 103 males, 80 male patients (79.2%) had coronary artery disease. According to our study, as correlated the coronary artery disease with various risk factors on computed tomography angiography. The patient had one or more than one risk factors; out of 132 patients, 72 patients (54.5%) had diabetes mellitus, 102 patients (77.3%) had hypertension, 55 patients (41.7%) had hyperlipidemia, 56 patients (42.4%) familial hypercholesterolemia, and 30(22.7%) were smokers. Conclusions: We concluded from our study that patients with Diabetes Mellitus (DM) were more prone to develope coronary artery disease CAD. Males were more at risk (79.2%) than females (20.8%) for CAD. Diabetes mellitus and hypertension were stronger predictors of CAD than smoking, hyperlipidemia and familial hypercholesterolemia. Keywords: Coronary Artery disease, Computed Tomography Angiogrpahy, Diabetes Mellitus, Hypertension

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