Low-fat diets do not lower plasma cholesterol levels in healthy men compared to high-fat diets with similar fatty acid composition at constant caloric intake

Lipids ◽  
1995 ◽  
Vol 30 (11) ◽  
pp. 969-976 ◽  
Author(s):  
Gary J. Nelson ◽  
Perla C. Schmidt ◽  
Darshan S. Kelley
Keyword(s):  
Plasma Cholesterol ◽  
Caloric Intake ◽  
High Fat ◽  
Lower Plasma ◽  
Healthy Men ◽  
Cholesterol Levels ◽  
High Fat Diets ◽  
Similar Fatty Acid Composition ◽  
Lower Plasma Cholesterol ◽  
Fat Diets

Hepatic Gene Expression Related to Lower Plasma Cholesterol in Hamsters Fed High-Fat Diets Supplemented with Blueberry Peels and Peel Extract†

2010 ◽  
Vol 58 (7) ◽  
pp. 3984-3991 ◽  
Author(s):  
Hyunsook Kim ◽  
Glenn E. Bartley ◽  
Agnes M. Rimando ◽  
Wallace Yokoyama
Keyword(s):  
Gene Expression ◽  
Plasma Cholesterol ◽  
Hepatic Gene Expression ◽  
High Fat ◽  
Lower Plasma ◽  
High Fat Diets ◽  
Lower Plasma Cholesterol ◽  
Fat Diets ◽  
Peel Extract

scholarly journals Black, pinto and white beans lower hepatic lipids in hamsters fed high fat diets by excretion of bile acids

2020 ◽  
Vol 2 (1) ◽  
Author(s):  
Priscila L. S. Alves ◽  
Jose De J Berrios ◽  
James Pan ◽  
Wallace H. Yokoyama
Keyword(s):  
Lithocholic Acid ◽  
Plasma Cholesterol ◽  
Liver Cholesterol ◽  
Control Group ◽  
Chow Diet ◽  
High Fat ◽  
Bean Flour ◽  
Freeze Dried ◽  
High Fat Diets ◽  
Fat Diets

Abstract Hypolipidemic and anti-obesity properties of extruded black, pinto and white beans were examined in male Syrian hamsters fed high fat diets for 3 weeks. The efficiency and effectiveness of extruder processing to eliminate heat-labile antinutrients were also determined. Hamsters fed a high fat diet containing 40% extruded black beans gained the same amount of weight as animals on a low-fat chow diet (based on AIN-93G). Total plasma cholesterol of the hamsters fed bean flour- based diets tended to be lower, ranging between 298 and 356 mg/dL, compared to 365 mg/dL for the control group and total and free liver cholesterol was about 50 and 33% lower, respectively, in the livers (freeze-dried) of hamsters fed the black turtle bean (BB) and pinto bean (PB) diets. The nitrogen content of the feces from hamsters fed the PB and white bean (WB) diets were 2.6x higher than the control and the excretion of deoxycholic acid (DCA) and lithocholic acid (LCA) was higher in all legume fed hamsters The results show that extrusion efficiently and economically reduces anti-nutritive factors that inhibit the digestion and absorption of proteins and carbohydrates. Graphical abstract

Free‐Choice and No‐Choice High‐Fat Diets Affect Striatal Dopamine D 2/3 Receptor Availability, Caloric Intake, and Adiposity

Obesity ◽  
2012 ◽  
Vol 20 (8) ◽  
pp. 1738-1740 ◽  
Author(s):  
Elsmarieke Giessen ◽  
Susanne E. Fleur ◽  
Kora Bruin ◽  
Wim Brink ◽  
Jan Booij
Keyword(s):  
Free Choice ◽  
Caloric Intake ◽  
Striatal Dopamine ◽  
High Fat ◽  
High Fat Diets ◽  
Fat Diets

The effect of palmitic acid on endogeneous synthesis of cholesterol and on lipoprotein cholesterol levels in humans after feeding low or high fat diets

2000 ◽  
Vol 151 (1) ◽  
pp. 280
Author(s):  
M.T. Clandinin ◽  
S.L. Cook ◽  
S.D. Konrad ◽  
M.A. French ◽  
Y.K. Goh
Keyword(s):  
Palmitic Acid ◽  
Lipoprotein Cholesterol ◽  
High Fat ◽  
Cholesterol Levels ◽  
High Fat Diets ◽  
Fat Diets

scholarly journals Hypocholesterolaemic effects of plant sterol analogues are independent of ABCG5 and ABCG8 transporter expressions in hamsters

2007 ◽  
Vol 98 (3) ◽  
pp. 550-555 ◽  
Author(s):  
Xiaoming Jia ◽  
Naoyuki Ebine ◽  
Isabelle Demonty ◽  
Yanwen Wang ◽  
Robin Beech ◽  
...  
Keyword(s):  
Small Intestine ◽  
Mrna Expression ◽  
Plant Sterol ◽  
Plasma Cholesterol ◽  
Plant Sterols ◽  
Lower Plasma ◽  
Plant Stanols ◽  
Cholesterol Levels ◽  
Lower Plasma Cholesterol ◽  
Reduce Plasma Cholesterol

The hypolipidaemic effects of plant sterols are well established. However, mechanisms by which plant sterols lower plasma cholesterol levels, particularly at the molecular level, have not been clearly elucidated. The objective of the present study was to determine whether different plant sterol analogues reduce plasma cholesterol levels by up regulating the sterol transporters ABCG5 and ABCG8 in the liver and/or small intestine. Male Golden Syrian hamsters were divided into eight groups. Groups 1 and 2 were fed a maize starch–casein–sucrose-based diet that did not contain cholesterol (control; Con) or the Con diet with the addition of 0·25 % cholesterol (Ch-Con). Groups 3–8 were fed the Ch-Con diet supplemented with 1 % plant sterols, 1 % plant stanols, 1 % of a plant sterol and stanol mixture (50:50), 1·76 % plant sterol–fish oil esters, or 0·71 or 1·43 % stanol–ascorbic acid esters, respectively. After 5 weeks, the Ch-Con diet up regulated the ABCG5 mRNA expression and tended (P = 0·083) to increase ABCG8 mRNA expression in the liver, but did not affect both genes’ expression in the small intestine compared with the Con diet. Hamsters fed 0·7 % stanol esters showed lower plasma cholesterol levels (P < 0·001) and also lower liver ABCG5 mRNA expression (P < 0·05) compared with the Ch-Con diet. Plant stanols, stanol esters, and sterol esters did not affect the ABCG5 or ABCG8 mRNA expressions in the liver and intestine although they reduced plasma cholesterol levels. These results suggest that plant sterols and their derivatives reduce plasma cholesterol levels independently from the mRNA expression of ABCG5 and ABCG8 transporters.

Determinants of high-fat diet hyperphagia: experimental dissection of orosensory and postingestive effects

1995 ◽  
Vol 269 (1) ◽  
pp. R30-R37 ◽  
Author(s):  
Z. S. Warwick ◽  
H. P. Weingarten
Keyword(s):  
High Fat Diet ◽  
Caloric Intake ◽  
Oral Feeding ◽  
Laboratory Animals ◽  
High Fat ◽  
Short Term ◽  
Sham Feeding ◽  
High Carbohydrate ◽  
High Fat Diets ◽  
Fat Diets

High-fat diets often promote greater caloric intake and/or weight gain than high-carbohydrate diets in both laboratory animals and humans. Because altering the fat content of a diet simultaneously changes both its sensory properties and postingestive effects, it is unclear whether high-fat hyperphagia is due to the diet's palatability, its postingestive effects, or both. The present studies isolated the independent capacity of the orosensory and postingestive effects of a liquid high-fat diet (High-Fat) to produce overeating relative to an isocaloric liquid high-carbohydrate (High-CHO) diet. Rats fed High-Fat orally ate more calories and gained more weight over 16 days than rats fed High-CHO orally. One-bottle sham-feeding intake of High-Fat and High-CHO did not differ, but in two-bottle sham-feeding tests High-Fat was clearly preferred. When orosensory influences on intake were equated via chronic self-regulated intragastric feeding, High-Fat still promoted greater intake than High-CHO, although absolute intake across both diets was lower during intragastric feeding relative to oral feeding. An analysis of short-term intake revealed that rats accustomed to infusion of High-CHO increased meal size immediately when switched to High-Fat. The present results, coupled with previous findings, suggest that the postingestive effects of fat enhance daily caloric intake in two ways: 1) during a meal, fat produces less suppression of intake per calorie than carbohydrate; and 2) after a meal, fat produces less suppression of intake per calorie during the intermeal interval than carbohydrate.

Effects of high-fat diets with different carbohydrate-to-protein ratios on energy homeostasis in rats with impaired brain melanocortin receptor activity

2005 ◽  
Vol 289 (1) ◽  
pp. R156-R163 ◽  
Author(s):  
C. Morens ◽  
M. Keijzer ◽  
K. de Vries ◽  
A. Scheurink ◽  
G. van Dijk
Keyword(s):  
Body Weight ◽  
Energy Homeostasis ◽  
Caloric Intake ◽  
Melanocortin Receptor ◽  
High Fat ◽  
Macronutrient Composition ◽  
Plasma Adiponectin ◽  
High Fat Diets ◽  
Glucose Tolerant ◽  
Fat Diets

Changes in dietary macronutrient composition and/or central nervous system neuronal activity can underlie obesity and disturbed fuel homeostasis. We examined whether switching rats from a diet with high carbohydrate content (HC; i.e., regular chow) to diets with either high fat (HF) or high fat/high protein content at the expense of carbohydrates (LC-HF-HP) causes differential effects on body weight and glucose homeostasis that depend on the integrity of brain melanocortin (MC) signaling. In vehicle-treated rats, switching from HC to either HF or LC-HF-HP feeding caused similar reductions in food intake without alterations in body weight. A reduced caloric intake (−16% in HF and LC-HF-HP groups) required to maintain or increase body weight underlay these effects. Chronic third cerebroventricular infusion of the MC receptor antagonist SHU9119 (0.5 nmol/day) produced obesity and hyperphagia with an increased food efficiency again observed during HF (+19%) and LC-HF-HP (+33%) feeding. In this case, however, HF feeding exaggerated SHU9119-induced hyperphagia and weight gain relative to HC and LC-HF-HP feeding. Relative to vehicle-treated controls, SHU9119 treatment increased plasma insulin (2.8–4 fold), leptin (7.7–15 fold), and adiponectin levels (2.4–3.7 fold), but diet effects were only observed on plasma adiponectin (HC and LC-HF-HP<HF). Finally, SHU9119-treated LC-HF-HP-fed rats were less glucose tolerant than others. Relatively low plasma adiponectin levels likely contributed to this effect. Thus HF feeding amplifies obesity induced by impaired MC signaling, provided that the carbohydrate-to-protein (C/P) ratio is high enough. Reduction of the C/P ratio within a HF diet ameliorates hyperphagia and obesity in rats with impaired MC signaling but aggravates associated disturbances in fuel homeostasis.

The use of diet to lower plasma cholesterol levels

1987 ◽  
Vol 8 (suppl E) ◽  
pp. 79-85 ◽  
Author(s):  
G. Riccardi ◽  
A. A. Rivellese ◽  
M. Mancini
Keyword(s):  
Plasma Cholesterol ◽  
Lower Plasma ◽  
Cholesterol Levels ◽  
Lower Plasma Cholesterol

scholarly journals Why Do Mice Overeat High-Fat Diets? How High-Fat Diet Alters the Regulation of Daily Caloric Intake in Mice

Obesity ◽  
2018 ◽  
Vol 26 (6) ◽  
pp. 1026-1033 ◽  
Author(s):  
Julia A. Licholai ◽  
Katrina P. Nguyen ◽  
Wambura C. Fobbs ◽  
Corbin J. Schuster ◽  
Mohamed A. Ali ◽  
...  
Keyword(s):  
High Fat Diet ◽  
Caloric Intake ◽  
High Fat ◽  
Daily Caloric Intake ◽  
High Fat Diets ◽  
Fat Diets
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