Hepatic Gene Expression Related to Lower Plasma Cholesterol in Hamsters Fed High-Fat Diets Supplemented with Blueberry Peels and Peel Extract†

2010 ◽  
Vol 58 (7) ◽  
pp. 3984-3991 ◽  
Author(s):  
Hyunsook Kim ◽  
Glenn E. Bartley ◽  
Agnes M. Rimando ◽  
Wallace Yokoyama
Keyword(s):  
Gene Expression ◽  
Plasma Cholesterol ◽  
Hepatic Gene Expression ◽  
High Fat ◽  
Lower Plasma ◽  
High Fat Diets ◽  
Lower Plasma Cholesterol ◽  
Fat Diets ◽  
Peel Extract

High-fat diets promote insulin resistance through cytokine gene expression in growing female rats

2008 ◽  
Vol 19 (8) ◽  
pp. 505-513 ◽  
Author(s):  
Anne M. Flanagan ◽  
Jackie L. Brown ◽  
Consuelo A. Santiago ◽  
Pauline Y. Aad ◽  
Leon J. Spicer ◽  
...  
Keyword(s):  
Gene Expression ◽  
Insulin Resistance ◽  
Female Rats ◽  
Cytokine Gene Expression ◽  
Cytokine Gene ◽  
High Fat ◽  
High Fat Diets ◽  
Fat Diets

scholarly journals Maternal and Post-weaning High-Fat Diets Produce Distinct DNA Methylation Patterns in Hepatic Metabolic Pathways within Specific Genomic Contexts

2019 ◽  
Vol 20 (13) ◽  
pp. 3229 ◽  
Author(s):  
Moody ◽  
Wang ◽  
Jung ◽  
Chen ◽  
Pan
Keyword(s):  
Gene Expression ◽  
Dna Methylation ◽  
Metabolic Pathways ◽  
Expression Patterns ◽  
Sprague Dawley ◽  
High Fat ◽  
Differentially Methylated Genes ◽  
High Fat Diets ◽  
Diet Intake ◽  
Fat Diets

Calorie-dense high-fat diets (HF) are associated with detrimental health outcomes, including obesity, cardiovascular disease, and diabetes. Both pre- and post-natal HF diets have been hypothesized to negatively impact long-term metabolic health via epigenetic mechanisms. To understand how the timing of HF diet intake impacts DNA methylation and metabolism, male Sprague–Dawley rats were exposed to either maternal HF (MHF) or post-weaning HF diet (PHF). At post-natal week 12, PHF rats had similar body weights but greater hepatic lipid accumulation compared to the MHF rats. Genome-wide DNA methylation was evaluated, and analysis revealed 1744 differentially methylation regions (DMRs) between the groups with the majority of the DMR located outside of gene-coding regions. Within differentially methylated genes (DMGs), intragenic DNA methylation closer to the transcription start site was associated with lower gene expression, whereas DNA methylation further downstream was positively correlated with gene expression. The insulin and phosphatidylinositol (PI) signaling pathways were enriched with 25 DMRs that were associated with 20 DMGs, including PI3 kinase (Pi3k), pyruvate kinase (Pklr), and phosphodiesterase 3 (Pde3). Together, these results suggest that the timing of HF diet intake determines DNA methylation and gene expression patterns in hepatic metabolic pathways that target specific genomic contexts.

scholarly journals Black, pinto and white beans lower hepatic lipids in hamsters fed high fat diets by excretion of bile acids

2020 ◽  
Vol 2 (1) ◽  
Author(s):  
Priscila L. S. Alves ◽  
Jose De J Berrios ◽  
James Pan ◽  
Wallace H. Yokoyama
Keyword(s):  
Lithocholic Acid ◽  
Plasma Cholesterol ◽  
Liver Cholesterol ◽  
Control Group ◽  
Chow Diet ◽  
High Fat ◽  
Bean Flour ◽  
Freeze Dried ◽  
High Fat Diets ◽  
Fat Diets

Abstract Hypolipidemic and anti-obesity properties of extruded black, pinto and white beans were examined in male Syrian hamsters fed high fat diets for 3 weeks. The efficiency and effectiveness of extruder processing to eliminate heat-labile antinutrients were also determined. Hamsters fed a high fat diet containing 40% extruded black beans gained the same amount of weight as animals on a low-fat chow diet (based on AIN-93G). Total plasma cholesterol of the hamsters fed bean flour- based diets tended to be lower, ranging between 298 and 356 mg/dL, compared to 365 mg/dL for the control group and total and free liver cholesterol was about 50 and 33% lower, respectively, in the livers (freeze-dried) of hamsters fed the black turtle bean (BB) and pinto bean (PB) diets. The nitrogen content of the feces from hamsters fed the PB and white bean (WB) diets were 2.6x higher than the control and the excretion of deoxycholic acid (DCA) and lithocholic acid (LCA) was higher in all legume fed hamsters The results show that extrusion efficiently and economically reduces anti-nutritive factors that inhibit the digestion and absorption of proteins and carbohydrates. Graphical abstract

Safflower (n-6) and flaxseed (n-3) high-fat diets differentially regulate hypothalamic fatty acid profiles, gene expression, and insulin signalling

2018 ◽  
Vol 128 ◽  
pp. 67-73 ◽  
Author(s):  
Maria Fernanda Fernandes ◽  
Maria Cristina Tache ◽  
Shannon L. Klingel ◽  
Francesco Leri ◽  
David M. Mutch
Keyword(s):  
Gene Expression ◽  
Fatty Acid ◽  
Insulin Signalling ◽  
Fatty Acid Profiles ◽  
High Fat ◽  
High Fat Diets ◽  
Fat Diets

scholarly journals The intake of high-fat diets induces the acquisition of brown adipocyte gene expression features in white adipose tissue

2015 ◽  
Vol 39 (11) ◽  
pp. 1619-1629 ◽  
Author(s):  
E García-Ruiz ◽  
B Reynés ◽  
R Díaz-Rúa ◽  
E Ceresi ◽  
P Oliver ◽  
...  
Keyword(s):  
Gene Expression ◽  
Adipose Tissue ◽  
White Adipose Tissue ◽  
Brown Adipocyte ◽  
High Fat ◽  
High Fat Diets ◽  
Fat Diets

scholarly journals Lasting Effects on Body Weight and Mammary Gland Gene Expression in Female Mice upon Early Life Exposure to n-3 but Not n-6 High-Fat Diets

PLoS ONE ◽  
2013 ◽  
Vol 8 (2) ◽  
pp. e55603 ◽  
Author(s):  
Mirjam Luijten ◽  
Amar V. Singh ◽  
Caleb A. Bastian ◽  
Anja Westerman ◽  
M. Michele Pisano ◽  
...  
Keyword(s):  
Gene Expression ◽  
Body Weight ◽  
Mammary Gland ◽  
Early Life ◽  
High Fat ◽  
Female Mice ◽  
Early Life Exposure ◽  
High Fat Diets ◽  
Fat Diets

Gene Expression Patterns Are Altered in Athymic Mice and Metabolic Syndrome Factors Are Reduced in C57BL/6J Mice Fed High-Fat Diets Supplemented with Soy Isoflavones

2016 ◽  
Vol 64 (40) ◽  
pp. 7492-7501 ◽  
Author(s):  
Ting Luo ◽  
Sarah M. Snyder ◽  
Bingxin Zhao ◽  
Debra K. Sullivan ◽  
Jill Hamilton-Reeves ◽  
...  
Keyword(s):  
Gene Expression ◽  
Metabolic Syndrome ◽  
Expression Patterns ◽  
Soy Isoflavones ◽  
Gene Expression Patterns ◽  
Athymic Mice ◽  
High Fat ◽  
High Fat Diets ◽  
Fat Diets
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