Elucidation of cyclic fatty acid monomer structures. Cyclic and bicyclic ring sizes and double bond position and configuration

1995 ◽  
Vol 72 (6) ◽  
pp. 721-727 ◽  
Author(s):  
Magdi M. Mossoba ◽  
Martin P. Yurawecz ◽  
John A. G. Roach ◽  
Hubert S. Lin ◽  
Richard E. McDonald ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Double Bond ◽  
Double Bond Position ◽  
Cyclic Fatty Acid ◽  
Cyclic Fatty Acid Monomer

Rapid determination of double bond configuration and position along the hydrocarbon chain in cyclic fatty acid monomers

Lipids ◽  
1994 ◽  
Vol 29 (12) ◽  
pp. 893-896 ◽  
Author(s):  
M. M. Mossoba ◽  
M. P. Yurawecz ◽  
J. A. G. Roach ◽  
H. S. Lin ◽  
R. E. McDonald ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Double Bond ◽  
Rapid Determination ◽  
Hydrocarbon Chain ◽  
Cyclic Fatty Acid ◽  
Cyclic Fatty Acid Monomers

Collision-Induced Dissociation of Fatty Acid [M – 2H + Na]– Ions: Charge-Directed Fragmentation and Assignment of Double Bond Position

2014 ◽  
Vol 25 (11) ◽  
pp. 1917-1926 ◽  
Author(s):  
Michael C. Thomas ◽  
Jens Altvater ◽  
Thomas J. Gallagher ◽  
Geoffrey W. Nette
Keyword(s):  
Fatty Acid ◽  
Double Bond ◽  
Double Bond Position ◽  
Collision Induced Dissociation ◽  
Na Ions

scholarly journals Metabolic plasticity in cancer activates apocryphal pathways for lipid desaturation

2020 ◽  
Author(s):  
Reuben S.E. Young ◽  
Andrew P. Bowman ◽  
Elizabeth D. Williams ◽  
Kaylyn D. Tousignant ◽  
Charles L. Bidgood ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Double Bond ◽  
Building Blocks ◽  
Double Bond Position ◽  
Alternative Pathways ◽  
Metabolic Plasticity ◽  
Lipid Desaturation ◽  
Complex Lipids ◽  
Complex Structural ◽  
Canonical Products

AbstractFatty acid (FA) modifications, such as enzymatic desaturation and elongation, have long been thought to involve sequential and highly specific enzyme-substrate interactions, which result in canonical products that are well-defined in their chain lengths, degree of unsaturation and double bond positions.1 These products act as a supply of building blocks for the synthesis of complex lipids supporting a symphony of lipid signals and membrane macrostructure. Recently, it was brought to light that differences in substrate availability due to enzyme inhibition can activate alternative pathways in a range of cancers, potentially altering the total species repertoire of FA metabolism.2,3 We have used isomer-resolved lipidomics to analyse human prostate tumours and cancer cell lines and reveal, for the first-time, the full extent of metabolic plasticity in cancer. Assigning the double bond position(s) in simple and complex lipids allows mapping of fatty acid desaturation and elongation via hitherto apocryphal metabolic pathways that generate FAs with unusual sites of unsaturation. Downstream utilisation of these FAs is demonstrated by their incorporation into complex structural lipids. The unsaturation profiles of different phospholipids reveal substantive structural variation between classes that will, necessarily, modulate lipid-centred biological processes in cancer cells including membrane fluidity3-5 and signal transduction.6-8

scholarly journals Redesign of soluble fatty acid desaturases from plants for altered substrate specificity and double bond position

1997 ◽  
Vol 94 (10) ◽  
pp. 4872-4877 ◽  
Author(s):  
E. B. Cahoon ◽  
Y. Lindqvist ◽  
G. Schneider ◽  
J. Shanklin
Keyword(s):  
Fatty Acid ◽  
Double Bond ◽  
Substrate Specificity ◽  
Double Bond Position ◽  
Fatty Acid Desaturases
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