Cobalt and/or manganese incorporated berlinites (CoMnAPO4) and aluminophosphate molecule sieve (CoMnAPO-5) were hydrothermally synthesized, characterized by XRD, FT-IR, XPS and SEM, and employed as catalysts in the oxidation of cyclohexane with molecular oxygen at 348 K under atmospheric pressure. It was found that the berlinite-based catalysts were more selective for the production of KA oil, stable during the reaction, but slightly less active for the conversion of cyclohexane, when compared to their molecular sieve counterparts. The CoMnAPO4exhibited a better catalytic performance, due to a synergic effect, than the CoAPO4or MnAPO4.