An orthotopic colon cancer model for studying the B7-H3 antitumor effect in vivo

2006 ◽  
Vol 10 (5) ◽  
pp. 635-645 ◽  
Author(s):  
Catalin M. Lupu ◽  
Christoph Eisenbach ◽  
Michael A. Kuefner ◽  
Jan Schmidt ◽  
Alaviana D. Lupu ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Antitumor Effect ◽  
Cancer Model

An Orthotopic Colon Cancer Model for Studying the B7-H3 Antitumor Effect In Vivo

2006 ◽  
Vol 10 (5) ◽  
pp. 635-645 ◽  
Author(s):  
C LUPU ◽  
C EISENBACH ◽  
M KUEFNER ◽  
J SCHMIDT ◽  
A LUPU ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Antitumor Effect ◽  
Cancer Model

scholarly journals In vivo distribution and antitumor effect of infused immune cells in a gastric cancer model

2012 ◽  
Vol 28 (5) ◽  
pp. 1743-1749 ◽  
Author(s):  
XIAOHUI DU ◽  
RUNSEN JIN ◽  
NING NING ◽  
LI LI ◽  
QUANSHENG WANG ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Immune Cells ◽  
Antitumor Effect ◽  
Cancer Model ◽  
In Vivo Distribution

scholarly journals Chemopreventive potential of β-Sitosterol in experimental colon cancer model - an In vitro and In vivo study

2010 ◽  
Vol 10 (1) ◽  
Author(s):  
Albert A Baskar ◽  
Savarimuthu Ignacimuthu ◽  
Gabriel M Paulraj ◽  
Khalid S Al Numair
Keyword(s):  
Colon Cancer ◽  
In Vivo Study ◽  
Cancer Model

scholarly journals Antitumor effect of sikokianin C, a selective cystathionine β-synthase inhibitor, against human colon cancer in vitro and in vivo

MedChemComm ◽  
2018 ◽  
Vol 9 (1) ◽  
pp. 113-120 ◽  
Author(s):  
Weining Niu ◽  
Fei Chen ◽  
Jun Wang ◽  
Jing Qian ◽  
Shasha Yan
Keyword(s):  
Colon Cancer ◽  
Cancer Cells ◽  
Antitumor Effect ◽  
Human Colon ◽  
Competitive Inhibitor ◽  
Colon Cancer Cells ◽  
Human Colon Cancer ◽  
Synthase Inhibitor

A natural biflavonoid compound, sikokianin C, which is a selective, competitive inhibitor of cystathionine β-synthase, inhibits the proliferation and growth of colon cancer cells in vitro and in vivo.

scholarly journals In vivo antitumor effect of electrochemotherapy on a hamster gingival cancer model.

2000 ◽  
Vol 12 (4) ◽  
pp. 343-348
Author(s):  
Susumu Omura ◽  
Kiyohide Fujita
Keyword(s):  
Antitumor Effect ◽  
Cancer Model

Antitumor Effect of Cycle Inhibiting Factor Expression in Colon Cancer via Salmonella VNP20009

2020 ◽  
Vol 20 (14) ◽  
pp. 1722-1727
Author(s):  
Liang Liu ◽  
Junhua Zhang ◽  
Mingqiang Gu ◽  
Guichao Li ◽  
Jianjiao Ni ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Colon Cancer ◽  
Salmonella Typhimurium ◽  
Antitumor Effect ◽  
Expression System ◽  
Xenograft Model ◽  
Sw480 Cell ◽  
Cell Cycle Regulators ◽  
Attenuated Salmonella Typhimurium

Background: Colon cancer is one of the major causes of morbidity and mortality worldwide. Cycle inhibiting factors (Cifs) have been shown to deamidate Nedd8, resulting in cell cycle arrest. Objective: To determine the antitumor effect of Cifs on colon cancer by using attenuated Salmonella typhimurium VNP20009. Methods: The VNP-SOPE2-cif and VNP-SOPE2-cif-C/A plasmids were transfected into attenuated Salmonella typhimurium VNP20009. The efficiency and specificity of the Cif promoter were validated in colon cancer SW480 cell lines. Western blotting was subsequently performed to evaluate cell cycle regulators, including P21, P27 and Wee1. In vivo, the antitumor effect of VNP20009 was evaluated in a colon cancer xenograft model. Results: Firstly, VNP-SOPE2-cif and VNP-SOPE2-cif-C/A were selectively expressed both in the bacterial and colon cancer cells. Cif expression in SW480 cells via the VNP tumor-targeted expression system induced the accumulation of Wee1, p21 and p27 expression. Moreover, tumor growth was significantly inhibited in the mice with VNP-SOPE2-cif compared to the mice with VNP with the empty construct. Conclusion: These results suggest that Cif gene delivered by VNP20009 is a promising approach for the treatment of colon cancer.

Improvement of Antitumor Effect of Intratumoral Injection of Immature Dendritic Cells Into Irradiated Tumor by Cyclophosphamide in Mouse Colon Cancer Model

2012 ◽  
Vol 35 (8) ◽  
pp. 607-614 ◽  
Author(s):  
Cheol-Hun Son ◽  
Dong Yeok Shin ◽  
Sung-Dae Kim ◽  
Hee-Seong Park ◽  
Min Ho Jung ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Dendritic Cells ◽  
Antitumor Effect ◽  
Intratumoral Injection ◽  
Cancer Model ◽  
Mouse Colon ◽  
Immature Dendritic Cells
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