Relationship between Matrix Metalloproteinase 2 and Lung Cancer Progression

2007 ◽  
Vol 11 (3) ◽  
pp. 183-192 ◽  
Author(s):  
Chun-Bao Guo ◽  
Shan Wang ◽  
Chun Deng ◽  
Dian-Liang Zhang ◽  
Fu-Ling Wang ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Matrix Metalloproteinase ◽  
Cancer Progression ◽  
Matrix Metalloproteinase 2

Capn4 promotes non-small cell lung cancer progression via upregulation of matrix metalloproteinase 2

2015 ◽  
Vol 32 (3) ◽  
Author(s):  
Jie Gu ◽  
Feng-kai Xu ◽  
Guang-yin Zhao ◽  
Chun-lai Lu ◽  
Zong-wu Lin ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Matrix Metalloproteinase ◽  
Small Cell Lung Cancer ◽  
Cancer Progression ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Matrix Metalloproteinase 2 ◽  
Small Cell Lung

scholarly journals Secernin-1 Contributes to Colon Cancer Progression through Enhancing Matrix Metalloproteinase-2/9 Exocytosis

2015 ◽  
Vol 2015 ◽  
pp. 1-12 ◽  
Author(s):  
Shengtao Lin ◽  
Tao Jiang ◽  
Yang Yu ◽  
Huamei Tang ◽  
Su Lu ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Matrix Metalloproteinase ◽  
Cancer Progression ◽  
Poor Prognosis ◽  
Bioinformatics Analysis ◽  
Tumor Development ◽  
Matrix Metalloproteinase 2 ◽  
Cancer Cell Proliferation ◽  
Colon Cancer Progression

Emerging evidence shows that exocytosis plays a key role in tumor development and metastasis. Secernin-1 (SCRN1) is a novel regulator of exocytosis. Our previous work identified SCRN1 as a tumor-associated gene by bioinformatics analysis of transcriptomes. In this study, we demonstrated the aberrant overexpression of SCRN1 at mRNA and protein level in colon cancer. We also revealed that overexpression of SCRN1 was significantly associated with the tumor development and poor prognosis. Experimentsin vitrovalidated that SCRN1 may promote cancer cell proliferation and secretion of matrix metalloproteinase-2/9 (MMP-2/9) proteins to accelerate tumor progression.

Grifolin Inhibits Proliferation, Migration, and Invasion of Lung Cancer A549 Cells by Regulating miRNA-1251-5p

2020 ◽  
Vol 12 (3) ◽  
pp. 376-382
Author(s):  
Xiao Liu ◽  
Yuanlan Chen ◽  
Zhijiao Jiang
Keyword(s):  
Lung Cancer ◽  
Matrix Metalloproteinase ◽  
Cellular Proliferation ◽  
A549 Cells ◽  
Matrix Metalloproteinase 2 ◽  
Migration And Invasion ◽  
Control Group ◽  
Inhibitory Influence ◽  
Proliferation Inhibition ◽  
Inhibition Rate

To investigate the effect and molecular mechanism of grifolin on the proliferation, transfer, and infiltration of lung cancer (LC) cells. A control group, low grifolin group, midium grifolin group and high grifolin group, anti-miRNA-NC group, anti-miRNA-1251-5p group, grifolin + miRNA-NC group, and grifolin + miRNA-1251-5p group were established based on LC A549 cells. MTT was employed to detect cellular proliferation inhibition rate; Transwell assay was used to detect cellular transfer and infiltration; Western blot was used to test Cyclin D1, cyclin-dependent kinase inhibitor 1A (p21), matrix metalloproteinase 2 (MMP-2), and matrix metalloproteinase 9 (MMP-9) protein expression; and finally RT-qPCR was employed to test miRNA-1251-5p expression. After treatment with different concentrations of grifolin, an increase in proliferation inhibition rate of A549 cells, a decrease in migrating and invading cells, a decrease in CyclinD1, MMP-2, and MMP-9 expression, an increase in p21 expression, and a decrease in miRNA-1251-5p expression in a manner of concentration dependence was observed (P < 0.05). Inhibiting miRNA-1251-5p expression led to an increase in cellular proliferation inhibition rate, a decrease in migrating and invading cells, a decrease in CyclinD1, MMP-2, and MMP-9 expression, and an increase in p21 expression (P < 0.05). Overexpression of miRNA-1251-5p reversed the inhibitory influence of grifolin on the proliferation, transfer, and infiltration of A549 cells. Grifolin likely inhibits the proliferation, transfer, and infiltration of LC A549 cells by down-regulating miRNA-1251-5p.

Role of serum matrix metalloproteinase-2 and -9 to predict breast cancer progression

2011 ◽  
Vol 44 (10-11) ◽  
pp. 869-872 ◽  
Author(s):  
Suprava Patel ◽  
G. Sumitra ◽  
B.C. Koner ◽  
Alpana Saxena
Keyword(s):  
Breast Cancer ◽  
Matrix Metalloproteinase ◽  
Cancer Progression ◽  
Breast Cancer Progression ◽  
Matrix Metalloproteinase 2

scholarly journals Tissue Inhibitor of Metalloproteinase 3 Suppresses Tumor Angiogenesis in Matrix Metalloproteinase 2–Down-regulated Lung Cancer

2008 ◽  
Vol 68 (12) ◽  
pp. 4736-4745 ◽  
Author(s):  
Chandramu Chetty ◽  
Sajani S. Lakka ◽  
Praveen Bhoopathi ◽  
Sateesh Kunigal ◽  
Roger Geiss ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Matrix Metalloproteinase ◽  
Tumor Angiogenesis ◽  
Tissue Inhibitor Of Metalloproteinase ◽  
Matrix Metalloproteinase 2 ◽  
Tissue Inhibitor

scholarly journals Matrix metalloproteinase 2/9-triggered-release micelles for inhaled drug delivery to treat lung cancer: preparation and in vitro/in vivo studies

2018 ◽  
Vol Volume 13 ◽  
pp. 4641-4659 ◽  
Author(s):  
Xiaofei Wang ◽  
Qinyue Chen ◽  
Xiaoyan Zhang ◽  
Xiaoqing Ren ◽  
Xiulei Zhang ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Drug Delivery ◽  
Matrix Metalloproteinase ◽  
In Vivo Studies ◽  
Matrix Metalloproteinase 2 ◽  
Triggered Release ◽  
Inhaled Drug Delivery
Sign in / Sign up

Export Citation Format

Share Document