Serum levels of dimeric activin A are not a marker of placental tumors in the course of chemotherapy

1998 ◽  
Vol 21 (3) ◽  
pp. 166-169 ◽  
Author(s):  
P. Florio ◽  
S. Luisi ◽  
E. Casarosa ◽  
A. R. Genazzani ◽  
P. Pautier ◽  
...  
Keyword(s):  
Serum Levels ◽  
Activin A ◽  
Placental Tumors

scholarly journals Inverse correlation between baseline inhibin B and FSH after stimulation with GnRH: a study of serum levels of inhibin A and B, pro alpha-C and activin A in women with ovulatory disturbances before and after stimulation with GnRH

2000 ◽  
pp. 77-84 ◽  
Author(s):  
FW Casper ◽  
RJ Seufert ◽  
K Pollow
Keyword(s):  
Inverse Correlation ◽  
Strong Relationship ◽  
Serum Levels ◽  
Activin A ◽  
Inhibin B ◽  
Inhibin A ◽  
Before And After ◽  
Pituitary Secretion ◽  
Objective Interest ◽  
A Minor

OBJECTIVE: Interest has focused recently on the influences of the polypeptide factors inhibin and activin on the selective regulation of the pituitary secretion of gonadotropins. DESIGN: Measurement of the concentrations of inhibin-related proteins in relation to the changes in pituitary gonadotropin (FSH, LH) parameters, after GnRH stimulation with a bolus injection of 100 microg gonadorelin, in 19 women with ovulatory disturbances. METHODS: Serum levels of inhibin A and B, activin A, and pro alpha-C were measured using sensitive ELISA kits. RESULTS: Within 60 min after GnRH stimulation, FSH values doubled from 5 to 10 mU/ml (P < 0.001). LH increased 12-fold from 2 to 24 mU/ml (P < 0.001). Activin A showed a significant decrease from 0.47 to 0.36 ng/ml (P < 0.001), whereas pro alpha-C increased from 127 to 156 pg/ml (P = 0.039). The median inhibin A concentration did not show a significant change between baseline and the 60 min value, whereas inhibin B was characterized by a minor, but not significant, increase in the median from 168 to 179 pg/ml (P = 0.408). A significant inverse correlation (P = 0.014) with a mean coefficient of correlation of 0.5516 was found, demonstrating a strong relationship between high inhibin B baseline levels and a small increase of FSH after 60 min. CONCLUSION: Our results show an interesting correlation between the baseline inhibin B and the change in FSH before and after GnRH stimulation. A high baseline inhibin B implies only a minor increase of FSH after 60 min.

scholarly journals Pregnancy-associated and placental proteins in the placental tissue of normal pregnant women and patients with pre-eclampsia at term

2002 ◽  
pp. 785-793 ◽  
Author(s):  
NA Bersinger ◽  
N Groome ◽  
S Muttukrishna
Keyword(s):  
Pregnant Women ◽  
Protein A ◽  
Placental Tissue ◽  
Serum Levels ◽  
Activin A ◽  
Placental Lactogen ◽  
Compensatory Mechanism ◽  
Protein Markers ◽  
Inhibin A ◽  
Placental Disease

OBJECTIVE: Pre-eclampsia is a placental disease of unknown cause. Maternal circulating concentrations of a number of protein markers are altered (mainly increased) in pre-eclampsia in comparison with controls of matched gestational age. Inhibin A and activin A were found to be elevated even before the onset of the disease. The aim of this study was to compare the levels of inhibin A, activin A: follistatin ratio, leptin, pregnancy-associated plasma protein-A (PAPP-A), human placental lactogen (HPL), placenta growth factor (PLGF) and pregnancy-specific beta1-glycoprotein (SP1) in placental extracts of normal pregnant women and pre-eclampsia patients at term. METHODS: Placental tissue from normal pregnancies (n=14) and patients with pre-eclampsia (n=13) were collected at term (> or =37 weeks of gestation) and stored at -80 degrees C. The frozen tissue pieces were homogenised and the above-mentioned proteins were measured by specific enzyme-linked immunosorbent assays. RESULTS: Placental contents of inhibin A and PAPP-A were significantly higher (P<0.05) in pre-eclampsia placental extracts compared with the controls. Activin A:follistatin ratio was higher (23) in pre-eclampsia extracts than in the controls (15). Leptin, PLGF, SP1 and HPL levels were not altered in the term pre-eclampsia placenta. Inhibin A and PAPP-A contents were increased in the placental extracts of pre-eclampsia patients. CONCLUSION: Our data suggest that the placenta, possibly by a compensatory mechanism, is at least in part responsible for the altered serum levels observed in pre-eclampsia.

640: Elevated activin A and soluble endoglin serum levels in first trimester harald pre-eclampsia

2013 ◽  
Vol 208 (1) ◽  
pp. S271
Author(s):  
Marc Baumann ◽  
Nick Bersinger ◽  
Luigi Raio ◽  
Christiane Albrecht ◽  
Susanne Gerber ◽  
...  
Keyword(s):  
Serum Levels ◽  
First Trimester ◽  
Activin A ◽  
Soluble Endoglin

Activin A: Serum levels and immunohistochemical brain localization in rats given diets deficient in l-lysine or protein

1993 ◽  
Vol 54 (3) ◽  
pp. 459-466 ◽  
Author(s):  
K Torii ◽  
K Hanai ◽  
K Oosawa ◽  
M Funaba ◽  
A Okiyama ◽  
...  
Keyword(s):  
Serum Levels ◽  
Activin A ◽  
Brain Localization

scholarly journals Changes in peripheral serum levels of total activin A during the human menstrual cycle and pregnancy.

1996 ◽  
Vol 81 (9) ◽  
pp. 3328-3334
Author(s):  
S Muttukrishna ◽  
P A Fowler ◽  
L George ◽  
N P Groome ◽  
P G Knight
Keyword(s):  
Menstrual Cycle ◽  
Serum Levels ◽  
Activin A ◽  
Human Menstrual Cycle

scholarly journals Correlation between Blood Activin Levels and Clinical Parameters of Type 2 Diabetes

2012 ◽  
Vol 2012 ◽  
pp. 1-9 ◽  
Author(s):  
Hui Wu ◽  
Michael Wu ◽  
Yi Chen ◽  
Carolyn A. Allan ◽  
David J. Phillips ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Glucose Tolerance ◽  
Fasting Glucose ◽  
Serum Levels ◽  
Activin A ◽  
Oral Glucose ◽  
Clinical Parameters ◽  
Model Assessment

Aims. Activins A and B, and their binding protein, follistatin, regulate glucose metabolism and inflammation. Consequently, their role in type 2 diabetes (T2D) was examined.Methods. Blood was taken from fasted participants (34 males; 58 females; 50–75 years) with diabetes or during an oral glucose tolerance test (OGTT). Clinical parameters were assessed, and blood assayed for activins, follistatin, and C-reactive protein.Results. Serum levels of activin A (93.3 ± 27.0 pg/mL, mean ± SD), B (81.8 ± 30.8 pg/mL), or follistatin (6.52 ± 3.15 ng/mL) were not different (P>0.05) between subjects with normal OGTT (n=39), impaired glucose tolerance and/or fasting glucose (n=17), or T2D (n=36). However, activin A and/or activin B were positively correlated with parameters of insulin resistance and T2D, including fasting glucose (P<0.001), fasting insulin (P=0.02), glycated hemoglobin (P=0.003), and homeostasis model assessment of insulin resistance (HOMA-IR;P<0.001). Follistatin was positively correlated with HOMA-IR alone (P=0.01).Conclusions. These data indicate that serum measurements of activin A, B, or follistatin cannot discriminate risk for T2D in individual patients, but the activins display a positive relationship with clinical parameters of the disease.

scholarly journals PERBEDAAN RERATA KADAR AKTIVIN A SERUM MATERNAL ANTARA PREEKLAMSIA BERAT DENGAN BUKAN PREEKLAMSIA BERAT

2019 ◽  
Vol 1 (1) ◽  
pp. 30-37
Author(s):  
Dovy Djanas ◽  
Bayu Pramudyo Ariwibowo ◽  
Hafni Bachtiar
Keyword(s):  
Serum Levels ◽  
Activin A ◽  
Maternal Serum ◽  
Severe Preeclampsia ◽  
Inclusion Criteria ◽  
Exclusion Criteria ◽  
Cross Sectional ◽  
Tnf Α ◽  
The Mean ◽  
In Pregnancy

At the start of preelampsia there is a failure of cytotrophoblst invasion into the maternal spiral arteries that will lead to decreased uteroplacetal perfusion which will be followed by the failure of the unit fetoplacenter to get enough oxygen from the room intervillous that ultimately lead to a state of hypoxia in placenta. This will cause the expenditure of TNF-α dan IL-1β from placenta and a factors called hypoxia-inducible transcription factors that will spur the trophoblast to produce activin A lot more. This research was conducted by cross sectional method in maternal room of obstetrics and gynecology department of Central General Hospital of Dr. M. Djamil Padang from August 2015 until February 2016 with 20 patients of severe preeclampsia and 20 patients not severe preeclampsia, who met inclusion criteria and there is no exclusion criteria. Then performed statistical analysis using Mann-Whitney test to determine difference in mean maternal activin A serum levels of severe preeclampsia and not severe preeclampsia. The mean maternal serum levels of activin A in severe preeclampsia is 32,55 ± 1,84 ng/ml and in pregnancy with no severe preeclampsia is 8,59 ± 0,59 ng/ ml. Difference in mean maternal serum level of activin A in the two groups was statistically significant (p=0,001). Ma-ternal serum activin A levels is significantly higher in severe preeclampsia than pregnancy with no severe preeclampsia.Keywords: Activin A, severe preeclampsia, not severe preeclampsia

Maternal serum levels of total activin-A in first-trimester trisomy 21 pregnancies

10.1002/pd.53 ◽  
2001 ◽  
Vol 21 (4) ◽  
pp. 270-273 ◽  
Author(s):  
Kevin Spencer ◽  
Adolfo W Liao ◽  
Hariklea Skentou ◽  
Charas YT Ong ◽  
Kypros H Nicolaides
Keyword(s):  
Trisomy 21 ◽  
Serum Levels ◽  
First Trimester ◽  
Activin A ◽  
Maternal Serum
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