Heart fatty acid unsaturation and lipid peroxidation, and aging rate, are lower in the canary and the parakeet than in the mouse

1999 ◽  
Vol 11 (1) ◽  
pp. 44-49 ◽  
Author(s):  
R. Pamplona ◽  
M. Portero-Otín ◽  
D. Riba ◽  
F. Ledo ◽  
R. Gredilla ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Fatty Acid ◽  
Aging Rate ◽  
Fatty Acid Unsaturation

Relationship between Fatty Acid Unsaturation, Sensitivity to Lipid Peroxidation, and Maximum Life Span in the Liver of Mammals

1998 ◽  
Vol 854 (1 TOWARDS PROLO) ◽  
pp. 516-516 ◽  
Author(s):  
R. PAMPLONA ◽  
M. PORTERO-OTIN ◽  
D. RIBA ◽  
M. LOPEZ-TORRES ◽  
G. BARJA
Keyword(s):  
Lipid Peroxidation ◽  
Fatty Acid ◽  
Life Span ◽  
Maximum Life Span ◽  
Fatty Acid Unsaturation

scholarly journals Role of Lipid Composition and Lipid Peroxidation in the Sensitivity of Fungal Plant Pathogens to Aluminum Chloride and Sodium Metabisulfite

2007 ◽  
Vol 73 (9) ◽  
pp. 2820-2824 ◽  
Author(s):  
Tyler J. Avis ◽  
Mélanie Michaud ◽  
Russell J. Tweddell
Keyword(s):  
Lipid Peroxidation ◽  
Fatty Acid ◽  
Aluminum Chloride ◽  
Plant Pathogens ◽  
Membrane Lipids ◽  
Membrane Integrity ◽  
Sodium Metabisulfite ◽  
Fatty Acid Unsaturation ◽  
Fungal Plant Pathogens

ABSTRACT Aluminum chloride and sodium metabisulfite have shown high efficacy at low doses in controlling postharvest pathogens on potato tubers. Direct effects of these two salts included the loss of cell membrane integrity in exposed pathogens. In this work, four fungal potato pathogens were studied in order to elucidate the role of membrane lipids and lipid peroxidation in the relative sensitivity of microorganisms exposed to these salts. Inhibition of mycelial growth in these fungi varied considerably and revealed sensitivity groups within the tested fungi. Analysis of fatty acids in these fungi demonstrated that sensitivity was related to high intrinsic fatty acid unsaturation. When exposed to the antifungal salts, sensitive fungi demonstrated a loss of fatty acid unsaturation, which was accompanied by an elevation in malondialdehyde content (a biochemical marker of lipid peroxidation). Our data suggest that aluminum chloride and sodium metabisulfite could induce lipid peroxidation in sensitive fungi, which may promote the ensuing loss of integrity in the plasma membrane. This direct effect on fungal membranes may contribute, at least in part, to the observed antimicrobial effects of these two salts.

Unsaturated fatty acid-tuned assembly of photosensitizers for enhanced photodynamic therapy via lipid peroxidation

2021 ◽  
Vol 334 ◽  
pp. 213-223
Author(s):  
Yanxian Hou ◽  
Qiang Fu ◽  
Yafei Kuang ◽  
Dan Li ◽  
Yixin Sun ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Photodynamic Therapy ◽  
Fatty Acid ◽  
Unsaturated Fatty Acid

scholarly journals miR-21-5p regulates mitochondrial respiration and lipid content in H9C2 cells

2019 ◽  
Vol 316 (3) ◽  
pp. H710-H721 ◽  
Author(s):  
Victoria L. Nasci ◽  
Sandra Chuppa ◽  
Lindsey Griswold ◽  
Kathryn A. Goodreau ◽  
Ranjan K. Dash ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Fatty Acid ◽  
Palmitic Acid ◽  
Fatty Acid Oxidation ◽  
Lipid Content ◽  
Mitochondrial Respiration ◽  
Acid Oxidation ◽  
H9c2 Cells ◽  
Cellular Lipid ◽  
Transfected Cells

Cardiovascular-related pathologies are the single leading cause of death in patients with chronic kidney disease (CKD). Previously, we found that a 5/6th nephrectomy model of CKD leads to an upregulation of miR-21-5p in the left ventricle, targeting peroxisome proliferator-activated receptor-α and altering the expression of numerous transcripts involved with fatty acid oxidation and glycolysis. In the present study, we evaluated the potential for knockdown or overexpression of miR-21-5p to regulate lipid content, lipid peroxidation, and mitochondrial respiration in H9C2 cells. Cells were transfected with anti-miR-21-5p (40 nM), pre-miR-21-5p (20 nM), or the appropriate scrambled oligonucleotide controls before lipid treatment in culture or as part of the Agilent Seahorse XF fatty acid oxidation assay. Overexpression of miR-21-5p attenuated the lipid-induced increase in cellular lipid content, whereas suppression of miR-21-5p augmented it. The abundance of malondialdehyde, a product of lipid peroxidation, was significantly increased with lipid treatment in control cells but attenuated in pre-miR-21-5p-transfected cells. This suggests that miR-21-5p reduces oxidative stress. The cellular oxygen consumption rate (OCR) was increased in both pre-miR-21-5p- and anti-miR-21-5p-transfected cells. Levels of intracellular ATP were significantly higher in anti-mR-21-5p-transfected cells. Pre-miR-21-5p blocked additional increases in OCR in response to etomoxir and palmitic acid. Conversely, anti-miR-21-5p-transfected cells exhibited reduced OCR with both etomoxir and palmitic acid, and the glycolytic capacity was concomitantly reduced. Together, these results indicate that overexpression of miR-21-5p attenuates both lipid content and lipid peroxidation in H9C2 cells. This likely occurs by reducing cellular lipid uptake and utilization, shifting cellular metabolism toward reliance on the glycolytic pathway. NEW & NOTEWORTHY Both overexpression and suppression of miR-21-5p augment basal and maximal mitochondrial respiration. Our data suggest that reliance on glycolytic and fatty acid oxidation pathways can be modulated by the abundance of miR-21-5p within the cell. miR-21-5p regulation of mitochondrial respiration can be modulated by extracellular lipids.

Phospholipid fatty acid composition, vitamin e content and susceptibility to lipid peroxidation of duck spermatozoa

2000 ◽  
Vol 53 (5) ◽  
pp. 1025-1039 ◽  
Author(s):  
P.F. Surai ◽  
J-P. Brillard ◽  
B.K. Speake ◽  
E. Blesbois ◽  
F. Seigneurin ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Fatty Acid Composition ◽  
Fatty Acid ◽  
Vitamin E ◽  
Acid Composition ◽  
Phospholipid Fatty Acid ◽  
Phospholipid Fatty Acid Composition
Sign in / Sign up

Export Citation Format

Share Document