The relationship between retinol-binding protein 4 and apolipoprotein B-containing lipoproteins is attenuated in patients with very high serum triglycerides: A pilot study

Background: The prevous studies has showed that serum retinol binding protein 4 (RBP4) levels increased in metobolic disorders which are closely associated with cardiovascular dieases (CVD). However the human studies investigating the role of RBP4 in CVD are conflicted. Therefore, we aimed to evaluate the relationship between RBP4 and the presence and the severity of coronary artery disease (CAD) in this study. Methods: 55 patients with presenting acute coronary syndrome (ACS) and 43 control subjects who had various cardiovascular risk factors with normal coronary artery on coronary angiography were included in this study.The serum RBP4 concentrations were measured using ELISA method and clinically and anatomically score models were used to asses the severity of coronary lesion. Results: Serum RBP4 level was significantly higher in patients with ACS compared to the controls (68.40 ± 47.94 mg/L vs. 49.46 ± 13.64 mg/L; p = 0.014). RBP4 was correlated with GENSINI and SYNTAX I score (r = 0,286 p=0,034; r = 0.403 p = 0.002 respectively). However, there was no relationship between RBP4 and GRACE score. Conclusion: Patients with ACS had increased serum RBP4 levels and its high levels were correlated with CAD severity.

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The Relationship Between Retinol/Retinol Binding Protein 4 ratio, resistin and inflammation in non diabetic obese Indonesian men

Medical Journal of Indonesia ◽

10.13181/mji.v19i1.384 ◽

2010 ◽

pp. 57

Author(s):

Anna Meiliana ◽

Gatot S. Lawrence ◽

Lhamjaya Patellongi ◽

Andi Wijaya ◽

Suryani As’ad

Keyword(s):

Binding Protein ◽

Retinol Binding Protein ◽

Retinol Binding Protein 4 ◽

The Relationship

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The Relationship between Retinol-Binding Protein 4 and Markers of Inflammation and Thrombogenesis in Children with Kawasaki Disease

Mediators of Inflammation ◽

10.1155/2021/7029514 ◽

2021 ◽

Vol 2021 ◽

pp. 1-7

Author(s):

Maoling Yang ◽

Haobo Weng ◽

Qiongfei Pei ◽

Fengchuan Jing ◽

Qijian Yi

Keyword(s):

Kawasaki Disease ◽

Negative Correlation ◽

Binding Protein ◽

Retinol Binding Protein ◽

Enzyme Linked Immunosorbent Assay ◽

Positive Correlation ◽

Retinol Binding Protein 4 ◽

Markers Of Inflammation ◽

The Relationship ◽

Time Point

Background. Kawasaki disease (KD) is a self-limited vasculitis with unknown etiologies, and coronary artery lesions (CALs) are the most common and serious complications. Retinol-binding protein 4 (RBP4) has been confirmed effects on vasodilation, platelet activation inhibition, and cardiovascular diseases by researches. Therefore, this study was aimed at investigating the relationship between RBP4 and inflammation as well as thrombogenesis in children with KD. Methods. 79 subjects were from 62 children with KD and 17 healthy controls (HCs). The KD group was divided into KD with CALs (KD-CALs) and KD without CALs (KD-NCALs), and the serum RBP4 levels were measured by enzyme-linked immunosorbent assay (ELISA). Results. Compared with the HC group, serum RBP4 levels in the KD group were significantly decreased ( p < 0.05 ). RBP4, hemoglobin (Hb), and mean platelet volume (MPV) levels were higher, while platelet counts (Plt) and thrombin time (TT) levels were lower in the KD-NCALs group than in the KD-CALs group ( p < 0.05 ). RBP4 had positive correlation with time point of intravenous immunoglobulin (IVIG), Hb, and percentage of leukomonocytes (L%) and negative correlation with the percentage of neutrophils (N%), MPV, C-reactive protein (CRP), neutrophil-to-lymphocyte ratio (NLR), prothrombin time (PT), fibrinogen (Fbg), and D-dimer (DD) in the KD group; RBP4 had positive correlation with the time point of IVIG and L% and negative correlation with N%, MPV, and NLR in the KD-NCALs group; and RBP4 had positive correlation with Hb and L% and negative correlation with N%, CRP, NLR, and PT in the KD-CALs group ( p < 0.05 ). Multiple linear regression analysis confirmed that Hb and CRP in the KD group, MPV and N% in the KD-NCALs group, and PT and CRP in the KD-CALs group were independent predictors of RBP4 ( p < 0.05 ). Conclusion. Lower RBP4 was observed in the KD group than in the HC group, and RBP4 had associations with markers of inflammation and thrombogenesis in children with KD.

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The Relationship between Serum Retinol-Binding Protein 4 Levels and Coronary Artery Disease in Korean Adults

Korean Diabetes Journal ◽

10.4093/kdj.2009.33.2.105 ◽

2009 ◽

Vol 33 (2) ◽

pp. 105

Author(s):

Ji-Hoon Kim ◽

Eun-Jung Rhee ◽

Eun-Suk Choi ◽

Jong-Chul Won ◽

Cheol-Young Park ◽

...

Keyword(s):

Coronary Artery Disease ◽

Coronary Artery ◽

Binding Protein ◽

Retinol Binding Protein ◽

Serum Retinol ◽

Retinol Binding Protein 4 ◽

Korean Adults ◽

Artery Disease ◽

The Relationship

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The Changes in Plasma Retinol-Binding Protein 4 Levels are Associated With Those of the Apolipoprotein B-Containing Lipoproteins During Dietary and Drug Treatment

Angiology ◽

10.1177/0003319711407628 ◽

2011 ◽

Vol 63 (1) ◽

pp. 67-75 ◽

Cited By ~ 8

Author(s):

Georgios A. Christou ◽

Constantinos C. Tellis ◽

Moses S. Elisaf ◽

Alexandros D. Tselepis ◽

Dimitrios N. Kiortsis

Keyword(s):

Apolipoprotein B ◽

Binding Protein ◽

Low Density Lipoprotein ◽

Density Lipoprotein ◽

Retinol Binding Protein ◽

Percentage Change ◽

Lipoprotein Cholesterol ◽

Low Density ◽

Low Density Lipoprotein Cholesterol ◽

Retinol Binding Protein 4

We investigated the association between retinol-binding protein 4 (RBP4) and apolipoprotein B (ApoB)-containing lipoproteins. Obese or overweight, hypertriglyceridemic patients underwent the following interventions for 3 months: (1) Diet (n = 20), (2) Diet + fenofibrate (n = 18), (3) Diet + rimonabant (n = 8). Circulating RBP4 decreased during dietary treatment. The percentage change in RBP4 was positively correlated with the percentage changes in very-low density lipoprotein cholesterol ( r = .570, P = .02), low-density lipoprotein cholesterol ([LDL-C]; r = .605, P = .01), ApoB ( r = .705, P = .007), and small dense LDL-C ([sdLDL-C]; r = .872, P < .001). The percentage change in RBP4 was the best predictor of the percentage changes in sdLDL-C and ApoB. Rimonabant treatment reduced RBP4, whereas fenofibrate increased RBP4 during the first month of therapy followed by a subsequent decrease. In conclusion, RBP4 may significantly influence the metabolic pathways responsible for changes in ApoB lipoprotein subspecies, thus RBP4 may be associated with cardiovascular disease risk.

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