The Relationship between Retinol-Binding Protein 4 and Markers of Inflammation and Thrombogenesis in Children with Kawasaki Disease

Background. Kawasaki disease (KD) is a self-limited vasculitis with unknown etiologies, and coronary artery lesions (CALs) are the most common and serious complications. Retinol-binding protein 4 (RBP4) has been confirmed effects on vasodilation, platelet activation inhibition, and cardiovascular diseases by researches. Therefore, this study was aimed at investigating the relationship between RBP4 and inflammation as well as thrombogenesis in children with KD. Methods. 79 subjects were from 62 children with KD and 17 healthy controls (HCs). The KD group was divided into KD with CALs (KD-CALs) and KD without CALs (KD-NCALs), and the serum RBP4 levels were measured by enzyme-linked immunosorbent assay (ELISA). Results. Compared with the HC group, serum RBP4 levels in the KD group were significantly decreased ( p < 0.05 ). RBP4, hemoglobin (Hb), and mean platelet volume (MPV) levels were higher, while platelet counts (Plt) and thrombin time (TT) levels were lower in the KD-NCALs group than in the KD-CALs group ( p < 0.05 ). RBP4 had positive correlation with time point of intravenous immunoglobulin (IVIG), Hb, and percentage of leukomonocytes (L%) and negative correlation with the percentage of neutrophils (N%), MPV, C-reactive protein (CRP), neutrophil-to-lymphocyte ratio (NLR), prothrombin time (PT), fibrinogen (Fbg), and D-dimer (DD) in the KD group; RBP4 had positive correlation with the time point of IVIG and L% and negative correlation with N%, MPV, and NLR in the KD-NCALs group; and RBP4 had positive correlation with Hb and L% and negative correlation with N%, CRP, NLR, and PT in the KD-CALs group ( p < 0.05 ). Multiple linear regression analysis confirmed that Hb and CRP in the KD group, MPV and N% in the KD-NCALs group, and PT and CRP in the KD-CALs group were independent predictors of RBP4 ( p < 0.05 ). Conclusion. Lower RBP4 was observed in the KD group than in the HC group, and RBP4 had associations with markers of inflammation and thrombogenesis in children with KD.

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The Relationship of Retinol Binding Protein 4 to Changes in Insulin Resistance and Cardiometabolic Risk in Overweight Black Adolescents

The Journal of Pediatrics ◽

10.1016/j.jpeds.2008.07.018 ◽

2009 ◽

Vol 154 (1) ◽

pp. 67-73.e1 ◽

Cited By ~ 24

Author(s):

Elizabeth Goodman ◽

Timothy E. Graham ◽

Lawrence M. Dolan ◽

Stephen R. Daniels ◽

Eric R. Goodman ◽

...

Keyword(s):

Insulin Resistance ◽

Cardiometabolic Risk ◽

Black Adolescents ◽

Binding Protein ◽

Retinol Binding Protein ◽

Retinol Binding Protein 4 ◽

Relationship Of ◽

The Relationship

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Decreased levels of aquaporin-4 in the cerebrospinal fluid of patients with idiopathic intracranial hypertension

Cephalalgia ◽

10.1177/0333102416630592 ◽

2016 ◽

Vol 36 (14) ◽

pp. 1379-1384 ◽

Cited By ~ 1

Author(s):

Kathrin Doppler ◽

Morten Schütt ◽

Claudia Sommer

Keyword(s):

Cerebrospinal Fluid ◽

Intracranial Hypertension ◽

Idiopathic Intracranial Hypertension ◽

Binding Protein ◽

Aquaporin 4 ◽

Retinol Binding Protein ◽

Enzyme Linked Immunosorbent Assay ◽

Increased Intracranial Pressure ◽

Retinol Binding Protein 4

Background Idiopathic intracranial hypertension is characterized by increased intracranial pressure. Its pathogenesis is largely unknown. Aquaporins may play a role in the homeostasis of cerebrospinal fluid. Methods We aimed to elucidate the role of aquaporins in idiopathic intracranial hypertension by measuring the level of aquaporin-1 and aquaporin-4 in the cerebrospinal fluid and plasma of 28 patients and 29 controls by enzyme-linked immunosorbent assay. The adipokines leptin and retinol-binding protein 4 were also measured. Results We found a reduction in aquaporin-4 in the cerebrospinal fluid of patients. Leptin levels were increased in the cerebrospinal fluid and plasma of patients and were correlated with weight, body mass index and body fat. There was no difference between patients and controls in the levels of aquaporin-4 and retinol-binding protein 4. Conclusion Our data suggest that an imbalance of aquaporin-4 in the cerebrospinal fluid of patients with idiopathic intracranial hypertension may contribute to the pathogenesis of this disorder.

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Retinol Binding Protein 4 Levels relate to the presence and severity of coronary artery disease

Journal of Medical Biochemistry ◽

10.5937/jomb0-28846 ◽

2021 ◽

Author(s):

Gokay Nar ◽

Sara Cetin Sanlialp ◽

Rukiye Nar

Keyword(s):

Coronary Artery Disease ◽

Coronary Artery ◽

Binding Protein ◽

Retinol Binding Protein ◽

Serum Retinol ◽

Retinol Binding Protein 4 ◽

Coronary Syndrome ◽

Artery Disease ◽

The Relationship

Background: The prevous studies has showed that serum retinol binding protein 4 (RBP4) levels increased in metobolic disorders which are closely associated with cardiovascular dieases (CVD). However the human studies investigating the role of RBP4 in CVD are conflicted. Therefore, we aimed to evaluate the relationship between RBP4 and the presence and the severity of coronary artery disease (CAD) in this study. Methods: 55 patients with presenting acute coronary syndrome (ACS) and 43 control subjects who had various cardiovascular risk factors with normal coronary artery on coronary angiography were included in this study.The serum RBP4 concentrations were measured using ELISA method and clinically and anatomically score models were used to asses the severity of coronary lesion. Results: Serum RBP4 level was significantly higher in patients with ACS compared to the controls (68.40 ± 47.94 mg/L vs. 49.46 ± 13.64 mg/L; p = 0.014). RBP4 was correlated with GENSINI and SYNTAX I score (r = 0,286 p=0,034; r = 0.403 p = 0.002 respectively). However, there was no relationship between RBP4 and GRACE score. Conclusion: Patients with ACS had increased serum RBP4 levels and its high levels were correlated with CAD severity.

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Positive correlation between retinol binding protein 4 (RBP4) and triglyceride level in central obesity

IOP Conference Series Earth and Environmental Science ◽

10.1088/1755-1315/125/1/012167 ◽

2018 ◽

Vol 125 ◽

pp. 012167 ◽

Cited By ~ 1

Author(s):

S Oktaria ◽

D K Sari ◽

D Dalimunthe ◽

P C Eyanoer

Keyword(s):

Triglyceride Level ◽

Central Obesity ◽

Binding Protein ◽

Retinol Binding Protein ◽

Positive Correlation ◽

Retinol Binding Protein 4

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The Relationship Between Retinol/Retinol Binding Protein 4 ratio, resistin and inflammation in non diabetic obese Indonesian men

Medical Journal of Indonesia ◽

10.13181/mji.v19i1.384 ◽

2010 ◽

pp. 57

Author(s):

Anna Meiliana ◽

Gatot S. Lawrence ◽

Lhamjaya Patellongi ◽

Andi Wijaya ◽

Suryani As’ad

Keyword(s):

Binding Protein ◽

Retinol Binding Protein ◽

Retinol Binding Protein 4 ◽

The Relationship

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The relationship between retinol-binding protein 4 and apolipoprotein B-containing lipoproteins is attenuated in patients with very high serum triglycerides: A pilot study

HORMONES ◽

10.1007/bf03401408 ◽

2016 ◽

Vol 15 (1) ◽

pp. 99-105

Author(s):

Georgios A. Christou ◽

Constantinos C. Tellis ◽

Moses S. Elisaf ◽

Alexandras D. Tselepis ◽

Dimitrios N. Kiortsis

Keyword(s):

Pilot Study ◽

Apolipoprotein B ◽

Binding Protein ◽

High Serum ◽

Retinol Binding Protein ◽

Serum Triglycerides ◽

Retinol Binding Protein 4 ◽

The Relationship ◽

Very High

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Serum retinol-binding protein 4 levels in polycystic ovary syndrome

Endocrine Connections ◽

10.1530/ec-19-0116 ◽

2019 ◽

Vol 8 (6) ◽

pp. 709-717

Author(s):

Shilpa Lingaiah ◽

Laure Morin-Papunen ◽

Terhi Piltonen ◽

Inger Sundström-Poromaa ◽

Elisabet Stener-Victorin ◽

...

Keyword(s):

Insulin Resistance ◽

Polycystic Ovary Syndrome ◽

Polycystic Ovary ◽

Binding Protein ◽

Serum Levels ◽

Retinol Binding Protein ◽

Enzyme Linked Immunosorbent Assay ◽

Serum Retinol ◽

Ovary Syndrome ◽

Retinol Binding Protein 4

Objective Serum levels of retinol-binding protein 4 (RBP4), an adipokine thought to affect systemic insulin sensitivity, were compared between women with polycystic ovary syndrome (PCOS) and non-PCOS controls to evaluate the association of RBP4 with clinical, hormonal and metabolic parameters of PCOS. Subjects and methods Serum RBP4 levels were analysed in 278 women with PCOS (age range 18–57 years) and 191 non-PCOS controls (age 20–53 years) by enzyme-linked immunosorbent assay. Results Serum levels of RBP4 were increased in women with PCOS compared with control women in the whole population (45.1 ± 24.0 (s.d.) vs 33.5 ± 18.3 mg/L, P < 0.001). Age-stratified analysis showed that serum RBP4 levels were increased in women with PCOS aged ≤30 years compared with controls (47.7 ± 23.5 vs 27.1 ± 10.4 mg/L, P < 0.001), whereas no significant differences were seen in the other age groups. No significant correlations of RBP4 were seen with either steroids or indices of insulin resistance. Conclusions Although serum RBP4 levels were increased in younger women with PCOS compared with age-matched non-PCOS controls, RBP4 does not seem to be a good marker of insulin resistance or other metabolic derangements in women with PCOS.

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