Intracellular production of IL-2, IL-4 and IFN-? by peripheral blood CD3+ cells in intermittent allergic rhinitis

2005 ◽  
Vol 54 (2) ◽  
pp. 91-95 ◽  
Author(s):  
J. Gl�ck ◽  
B. Rogala ◽  
B. Mazur
Keyword(s):  
Allergic Rhinitis ◽  
Peripheral Blood ◽  
Intermittent Allergic Rhinitis

scholarly journals Sublingual immunotherapy increases Treg/Th17 ratio in allergic rhinitis

Open Medicine ◽  
2021 ◽  
Vol 16 (1) ◽  
pp. 826-832
Author(s):  
Jiarong Wang ◽  
Liansheng Qiu ◽  
Yimin Chen ◽  
Minyun Chen
Keyword(s):  
T Cells ◽  
Allergic Rhinitis ◽  
Retrospective Study ◽  
Regulatory T Cells ◽  
Visual Analog Scale ◽  
Peripheral Blood ◽  
Sublingual Immunotherapy ◽  
Analog Scale ◽  
Vas Score ◽  
Medication Score

Abstract Background Few studies investigated the effects of sublingual immunotherapy (SLIT) on the peripheral regulatory T cells (Tregs)/Th17 ratio. Objective To investigate the effectiveness of SLIT in children with allergic rhinitis (AR) and the effects on the Tregs/Th17 ratio. Methods This was a retrospective study of children who were treated for AR between April 2017 and March 2018 at one hospital. The patients were grouped according to the treatments they received: SLIT + pharmacotherapy vs pharmacotherapy alone. Results Eighty children (51 boys and 29 girls; 40/group) were included. The visual analog scale (VAS) and medication scores at 1 year in the SLIT + pharmacotherapy group were 2.70 ± 1.08 and 1.1 ± 0.8, respectively, which were lower than at baseline (7.7 ± 1.2 and 3.6 ± 1.0, respectively) (both Ps < 0.05). For the pharmacotherapy group, the VAS score was decreased at 1 year vs baseline (3.3 ± 1.2 vs 7.4 ± 1.0; P < 0.05), but the medication score did not change (P > 0.05). In the SLIT + pharmacotherapy group, the Treg percentage increased, while the Th17 percentage decreased at 1 year (both Ps < 0.01). The percentages of Tregs and Th17s did not change in the pharmacotherapy group (both Ps > 0.05). Conclusions SLIT + pharmacotherapy can increase the Treg percentage and decrease the Th17 percentage in the peripheral blood of children with AR.

scholarly journals Altered Expression of IFN-λ2 in Allergic Airway Disorders and Identification of Its Cell Origins

2016 ◽  
Vol 2016 ◽  
pp. 1-13 ◽  
Author(s):  
Qiuli Wang ◽  
Dong Chen ◽  
Hua Xie ◽  
Xiaoping Lin ◽  
Xuefeng Wang ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Mast Cells ◽  
Cd8 T Cells ◽  
Peripheral Blood ◽  
A549 Cells ◽  
Lung Cells ◽  
Elevated Plasma ◽  
Altered Expression ◽  
Cd8 Cells ◽  
Healthy Control

This study investigated the expression levels of interferon- (IFN-)λ2 in peripheral blood and tissues. The results showed that the levels of IFN-λ2 were elevated by 17.9% and 14.2% in the plasma of allergic rhinitis (AR) and combined rhinitis with asthma (AR + AS), which was positively correlated with the level of tryptase but negatively correlated with the level of IL-10. IFN-λ2 was predominately expressed in the CD16+ cells and CD14+ cells in healthy control subjects (HC) but upregulated only in CD8+ cells of AR and in eosinophils of asthma. It was observed that approximately 6.6% and 7.0% dispersed tonsil cells and 5.8% and 0.44% dispersed lung cells are IFN-λ2+ mast cells and macrophages. Moreover, tryptase and agonist peptides of PAR-2 induced enhanced IFN-λ2 mRNA expression in A549 cells. In conclusion, the elevated levels of IFN-λ2 in the plasma of AR and AR + AS indicate that IFN-λ2 is likely to contribute to the pathogenesis of allergic airway disorders. The potential origins of the elevated plasma IFN-λ2 include mast cells, macrophages, and epithelial cells in tissues, neutrophils, monocytes, CD8+ T cells, and eosinophils in peripheral blood. Development of IFN-λ2 related therapy may help to treat or prevent allergic airway disorders.

A role for neutrophils in intermittent allergic rhinitis

2004 ◽  
Vol 124 (5) ◽  
pp. 616-620 ◽  
Author(s):  
Mattias Fransson ◽  
Mikael Benson ◽  
Göran Wennergren ◽  
Lars-Olaf Cardell
Keyword(s):  
Allergic Rhinitis ◽  
Intermittent Allergic Rhinitis

Allergic rhinitis as a manifestation of the "atopic phenotype"

1995 ◽  
Vol 76 (1) ◽  
pp. 62-63
Author(s):  
V. N. Tsibulkina ◽  
M. I. Khasanova ◽  
G. V. Cherepnev
Keyword(s):  
Allergic Rhinitis ◽  
Cellular Immunity ◽  
Peripheral Blood ◽  
Clinical Immunology ◽  
Skin Testing ◽  
Humoral And Cellular Immunity ◽  
Republican Center

96 patients with allergic rhinitis aged from 24 to 40 years were under our supervision at the Republican Center of Clinical Immunology. Patients (40 men and 56 women) were followed regularly for 5 years. The duration of the disease did not exceed 10 years. The diagnostic program aimed to establish the signs of "atopic phenotype" and specific hypersensitivity in patients with allergic rhinitis. It included an allergic history, skin testing, provocative nasal tests, test of inhibition of natural emigration of leukocytes (TTEL) with histamine, determination of the number of eosinophils in peripheral blood, assessment of humoral and cellular immunity, HL-typing.

Potential Differences between Local and Systemic Allergic Rhinitis Induced by Birch Pollen

2020 ◽  
Vol 181 (11) ◽  
pp. 831-838
Author(s):  
Andrzej Bozek ◽  
Jolanta Zalejska Fiolka ◽  
Anna Krajewska Wojtys ◽  
Beata Galuszka ◽  
Anna Cudak
Keyword(s):  
Allergic Rhinitis ◽  
Birch Pollen ◽  
Provocation Test ◽  
Basophil Activation Test ◽  
Specific Ige ◽  
Immunological Parameters ◽  
Local Allergic Rhinitis ◽  
Before And After ◽  
Intermittent Allergic Rhinitis ◽  
Bet V1

<b><i>Introduction:</i></b> Different endotypes of rhinitis are known, but its pathomechanism has not been conclusively established. For example, the precise difference between systemic allergic rhinitis (SAR) and local allergic rhinitis (LAR) is still being checked. Comparison of patients with LAR and with allergies to birch of those with intermittent allergic rhinitis, same allergy, or with non-allergic rhinitis (NAR) was the purpose of this study. <b><i>Methods:</i></b> Twenty-six patients with LAR, 18 with SAR and allergy to birch, and 21 with NAR were included. Patients who met the inclusion criteria were selected to undergo the following procedures at baseline: medical examinations, nasal provocation test (NPT), detection of nasal-specific IgE to birch as well as basophil activation test (BAT). All immunological parameters were detected before and after NPT. <b><i>Results:</i></b> Concentration of nasal IgE to Bet v1 increased comparably in the LAR and SAR groups after NPT to birch as follows: in 21 (81%) patients with LAR, 14 (78%) with SAR, and in everyone in the NAR group. Serum concentration of allergen-specific IgE to Bet v1 increased significantly from a median of 20.7 (25–75% interval: 11.2–35.6) IU/mL to 29.9 (13.6–44.1) (<i>p</i> = 0.028) after NPT in patients with SAR. Allergen-specific IgE to Bet v1 was absent in all patients with LAR and NAR before and after NPT. BAT with Bet v1 was positive in 22 (85%) patients with LAR, in 14 (78%) with SAR, and 2 (9.5%) with NAR. <b><i>Conclusion:</i></b> These obtained data suggest there are no potential mechanisms that could explain LAR compared to SAR.

Sign in / Sign up

Export Citation Format

Share Document