3D-QSAR studies on lipid peroxidation inhibitory activity of chromone derivatives

2016 ◽  
Vol 25 (10) ◽  
pp. 2368-2379 ◽  
Author(s):  
Narumol Phosrithong ◽  
Jiraporn Ungwitayatorn
Keyword(s):  
Lipid Peroxidation ◽  
Inhibitory Activity ◽  
3D Qsar ◽  
Qsar Studies ◽  
Chromone Derivatives ◽  
Lipid Peroxidation Inhibitory Activity

3D QSAR Studies of Tricyclic Compounds as Porcupine Inhibitors for Wnt Pathway Inhibitory Activity

2018 ◽  
Vol 15 (7) ◽  
pp. 721-732
Author(s):  
Liqiang Meng ◽  
Liqian Sun ◽  
Chaoqun Yan ◽  
Dongxiao Cui ◽  
Jingrun Chen ◽  
...  
Keyword(s):  
Inhibitory Activity ◽  
Wnt Pathway ◽  
3D Qsar ◽  
Qsar Studies ◽  
Tricyclic Compounds

Synthesis and SAR/3D-QSAR studies on the COX-2 inhibitory activity of 1,5-diarylpyrazoles to validate the modified pharmacophore

2005 ◽  
Vol 40 (10) ◽  
pp. 977-990 ◽  
Author(s):  
Sunil K. Singh ◽  
V. Saibaba ◽  
K. Srinivasa Rao ◽  
P. Ganapati Reddy ◽  
Pankaj R. Daga ◽  
...  
Keyword(s):  
Inhibitory Activity ◽  
3D Qsar ◽  
Qsar Studies ◽  
Cox 2

3D-QSAR studies on chromone derivatives as HIV-1 protease inhibitors

2004 ◽  
Vol 689 (1-2) ◽  
pp. 99-106 ◽  
Author(s):  
Jiraporn Ungwitayatorn ◽  
Weerasak Samee ◽  
Jutarat Pimthon
Keyword(s):  
Protease Inhibitors ◽  
3D Qsar ◽  
Qsar Studies ◽  
Chromone Derivatives ◽  
Hiv 1

Lipid peroxidation inhibitory activity of some constituents isolated from the stem bark ofEucalyptus globulus

2000 ◽  
Vol 23 (2) ◽  
pp. 147-150 ◽  
Author(s):  
Bong-Sik Yun ◽  
In-Kyoung Lee ◽  
Jong-Pyung Kim ◽  
Sung-Hyun Chung ◽  
Gyu-Seop Shim ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Inhibitory Activity ◽  
Stem Bark ◽  
Lipid Peroxidation Inhibitory Activity

Synthesis and SAR/3D-QSAR Studies on the COX-2 Inhibitory Activity of 1,5-Diarylpyrazoles to Validate the Modified Pharmacophore.

ChemInform ◽  
2006 ◽  
Vol 37 (8) ◽  
Author(s):  
Sunil K. Singh ◽  
V. Saibaba ◽  
K. Srinivasa Rao ◽  
P. Ganapati Reddy ◽  
Pankaj R. Daga ◽  
...  
Keyword(s):  
Inhibitory Activity ◽  
3D Qsar ◽  
Qsar Studies ◽  
Cox 2

Limonoids from Meliaceae with Lipid Peroxidation Inhibitory Activity

2011 ◽  
Vol 6 (6) ◽  
pp. 1934578X1100600 ◽  
Author(s):  
Robert G. Fowles ◽  
Baldwin S. Mootoo ◽  
Russel S. Ramsewak ◽  
William F. Reynolds ◽  
Muraleedharan G. G. Nair
Keyword(s):  
Lipid Peroxidation ◽  
Antioxidant Activity ◽  
Inhibitory Activity ◽  
Natural Compounds ◽  
Lipid Peroxidation Inhibitory Activity ◽  
Positive Controls

In this study the antioxidant activity of natural limonoids from Meliaceae swietenolide (1), 3,6-O,O-diacetylswietenolide (2), swietenine (3), swietemahonin G (4) and 2-hydroxyswietenine (5) were investigated along with the semisynthetic analogues (6-25) of compounds 1, 3-4. Lipid peroxidation (LPO) inhibitory assays revealed 85.6, 13.3, 77.3, 61.2 and 24.6 % inhibition for the natural compounds 1-5. Excellent antioxidant activity was seen for the semisynthetic analogues 10 (98.3 %), 16-17, 21-22 and 25 (100 %), which were more active than the positive controls BHA (91.3 %) and TBHQ (95.7 %).

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