scholarly journals Magnetic Resonance Imaging Characteristics of Molecular Subgroups in Pediatric H3 K27M Mutant Diffuse Midline Glioma

2021 ◽  
Author(s):  
Annika Hohm ◽  
Michael Karremann ◽  
Gerrit H. Gielen ◽  
Torsten Pietsch ◽  
Monika Warmuth-Metz ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Imaging Data ◽  
Resonance Imaging ◽  
Molecular Subgroups ◽  
Hyperintense Signal ◽  
Dismal Prognosis ◽  
Large Patient ◽  
Imaging Characteristics ◽  
Diffuse Midline Glioma

Abstract Purpose Recent research identified histone H3 K27M mutations to be associated with a dismal prognosis in pediatric diffuse midline glioma (pDMG); however, data on detailed MRI characteristics with respect to H3 K27 mutation status and molecular subgroups (H3.1 and H3.3 K27M mutations) are limited. Methods Standardized magnetic resonance imaging (MRI) parameters and epidemiologic data of 68 pDMG patients (age <18 years) were retrospectively reviewed and compared in a) H3 K27M mutant versus H3 K27 wildtype (WT) tumors and b) H3.1 versus H3.3 K27M mutant tumors. Results Intracranial gliomas (n = 58) showed heterogeneous phenotypes with isointense to hyperintense signal in T2-weighted images and frequent contrast enhancement. Hemorrhage and necrosis may be present. Comparing H3 K27M mutant to WT tumors, there were significant differences in the following parameters: i) tumor localization (p = 0.001), ii) T2 signal intensity (p = 0.021), and iii) T1 signal homogeneity (p = 0.02). No significant imaging differences were found in any parameter between H3.1 and H3.3 K27M mutant tumors; however, H3.1 mutant tumors occurred at a younger age (p = 0.004). Considering spinal gliomas (n = 10) there were no significant imaging differences between the analyzed molecular groups. Conclusion With this study, we are the first to provide detailed MR imaging data on H3 K27M mutant pDMG with respect to molecular subgroup status in a large patient cohort. Our findings may support diagnosis and future targeted therapeutic trials of pDMG within the framework of the radiogenomics concept.

Magnetic Resonance Imaging Characteristics of Primary Intraspinal Peripheral Primitive Neuroectodermal Tumour

2013 ◽  
Vol 64 (3) ◽  
pp. 240-245 ◽  
Author(s):  
Guangyao Wu ◽  
Prasanna Ghimire ◽  
Ling Zhu ◽  
Aparajita Baral ◽  
Jiajia Su
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Resonance Imaging ◽  
Mri Findings ◽  
Primitive Neuroectodermal Tumour ◽  
Neuroectodermal Tumour ◽  
Hyperintense Signal ◽  
Imaging Characteristics ◽  
Thoracolumbar Region ◽  
Intradural Extramedullary

Purpose The purpose of our study was to describe the salient magnetic resonance imaging (MRI) findings in primary intraspinal peripheral primitive neuroectodermal tumour (PNET). Methods A retrospective review of the clinical and MRI images of 7 pathologically proven cases of intraspinal peripheral PNETs was performed. The various parameters, such as vertebral level of involvement; tumour location, size, focality, and margin; signal intensity of the lesion; the presence of hemorrhage or calcification; any signal voids; assessment of the adjacent cord for cord compression; cord dilatation; the presence of paraspinal tissue mass; or vertebral or other bony changes, were analysed. Results All 7 patients had lesions in the thoracolumbar region. Three patients had extradural lesions, 4 had intradural extramedullary lesions, and none had intramedullary lesions. Six lesions were well circumscribed. Only 1 patient had multifocal involvement. All lesions were of hypointense or isointense signal on T1-weighted imaging, whereas all but one were hyperintense on T2-weighted imaging. Lesions enhanced heterogeneously except 1 intradural extramedullary lesion, which enhanced homogeneously. A paraspinal mass was noticed in 2 patients. Vertebral collapse was present in 1 patients. Conclusion Intraspinal peripheral PNETs are rare spinal tumours. Although imaging characteristics are not specific, a focal circumscribed lesion in a young individual at the intramedullary, extramedullary intradural, or extradural spinal location that shows hypointense and hyperintense signal on T1- and T2-weighted images, respectively, requires PNET to be considered in the differentials.

Articulatory Synthesis Based on Real-Time Magnetic Resonance Imaging Data

2016 ◽  
Author(s):  
Asterios Toutios ◽  
Tanner Sorensen ◽  
Krishna Somandepalli ◽  
Rachel Alexander ◽  
Shrikanth S. Narayanan
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Real Time ◽  
Imaging Data ◽  
Resonance Imaging ◽  
Magnetic Resonance Imaging Data ◽  
Articulatory Synthesis

Imaging findings of trichilemmal cyst and proliferating trichilemmal tumour

2021 ◽  
pp. 197140092110177
Author(s):  
Masaya Kawaguchi ◽  
Hiroki Kato ◽  
Natsuko Suzui ◽  
Tatsuhiko Miyazaki ◽  
Hiroyuki Tomita ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Computed Tomography ◽  
Magnetic Resonance ◽  
Resonance Imaging ◽  
Hounsfield Units ◽  
Soft Tissue Density ◽  
Cutaneous Lesions ◽  
Imaging Characteristics ◽  
Trichilemmal Cyst ◽  
T1 Hyperintensity

Purpose The purpose of this study was to evaluate computed tomography and magnetic resonance imaging of benign trichilemmal cysts and proliferating trichilemmal tumours. Methods Nineteen histologically confirmed cutaneous lesions with trichilemmal keratinisation (12 trichilemmal cysts and seven proliferating trichilemmal tumours) were enrolled. Among them, 10 lesions (six trichilemmal cysts and four proliferating trichilemmal tumours) were examined by computed tomography, while 13 lesions (eight trichilemmal cysts and five proliferating trichilemmal tumours) were examined by magnetic resonance imaging. Computed tomography and magnetic resonance imaging characteristics were retrospectively reviewed. RESULTS Sixteen lesions (84%, 10 trichilemmal cysts and six proliferating trichilemmal tumours) occurred on the scalp. Lobulated margins were observed in five lesions (26%, three trichilemmal cysts and two proliferating trichilemmal tumours). With respect to computed tomography attenuation, calcification (>200 Hounsfield units) was observed in seven lesions (70%, five trichilemmal cysts and two proliferating trichilemmal tumours), hyperdense areas (≥80 and ≤200 Hounsfield units) in six (60%, three trichilemmal cysts and three proliferating trichilemmal tumours), and soft tissue density areas (<80 Hounsfield units) in nine (90%, five trichilemmal cysts and four proliferating trichilemmal tumours). On T1-weighted images, intratumoral hyperintensity was only observed in eight trichilemmal cysts but no proliferating trichilemmal tumours (100% vs. 0%, P<0.01). On T2-weighted images, hypointense rim and intratumoral hypointensity was observed in all 13 lesions (100%, eight trichilemmal cysts and five proliferating trichilemmal tumours), and linear or reticular hypointensity was observed in 10 (77%, six trichilemmal cysts and four proliferating trichilemmal tumours). Conclusion Trichilemmal cysts and proliferating trichilemmal tumours predominantly occurred on the scalp with calcification, and usually exhibited linear or reticular T2 hypointensity. Intratumoral T1 hyperintensity may be a useful imaging feature for differentiating trichilemmal cysts from proliferating trichilemmal tumours.

scholarly journals LAB–QA2GO: A Free, Easy-to-Use Toolbox for the Quality Assessment of Magnetic Resonance Imaging Data

2019 ◽  
Vol 13 ◽  
Author(s):  
Christoph Vogelbacher ◽  
Miriam H. A. Bopp ◽  
Verena Schuster ◽  
Peer Herholz ◽  
Andreas Jansen ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Quality Assessment ◽  
Imaging Data ◽  
Resonance Imaging ◽  
Magnetic Resonance Imaging Data

scholarly journals Parallel Imaging Artifacts in Body Magnetic Resonance Imaging

2009 ◽  
Vol 60 (2) ◽  
pp. 91-98 ◽  
Author(s):  
Patricia Noël ◽  
Roland Bammer ◽  
Caroline Reinhold ◽  
Masoom A. Haider
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Parallel Imaging ◽  
Negative Impact ◽  
Significant Advance ◽  
Resonance Imaging ◽  
Imaging Characteristics ◽  
Coil Geometry ◽  
Body Magnetic Resonance Imaging ◽  
Time Required

Objective To familiarize the reader with the fundamental concepts of partial parallel imaging (PPI); to review the technical aspects of PPI including calibration scan, coil geometry, and field of view (FOV); and to illustrate artifacts related to parallel imaging and describe solutions to minimize their negative impact. Results PPI has led to a significant advance in body magnetic resonance imaging by reducing the time required to generate an image without loss of spatial resolution. Although PPI can improve image quality, it is not free of artifacts, which can result in significant image degradation. Knowledge of these artifacts and how to minimize their effect is important to optimize the use of parallel imaging for specific body magnetic resonance imaging applications. Conclusions The reader will be introduced to the fundamental principles of PPI. Common imaging characteristics of PPI artifacts will be displayed with an emphasis on those seen with image-based methods, the principles behind their generation presented, and measures to minimize their negative impact will be proposed.

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