scholarly journals Family history of type 2 diabetes and characteristics of children with newly diagnosed type 1 diabetes

Diabetologia ◽  
2020 ◽  
Author(s):  
Anna Parkkola ◽  
◽  
Maaret Turtinen ◽  
Taina Härkönen ◽  
Jorma Ilonen ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Type 1 Diabetes ◽  
Family History ◽  
Positive Family History ◽  
Newly Diagnosed ◽  
Family History Of Diabetes ◽  
The Family ◽  
History Of

Abstract Aims/hypothesis Shared aetiopathogenetic factors have been proposed in type 1 diabetes and type 2 diabetes and both diseases have been shown to cluster in families. Characteristics related to type 2 diabetes have been described in patients with type 1 diabetes with a positive family history of type 2 diabetes. We wanted to characterise the family history of type 2 diabetes and its possible effects on the phenotype and genotype of type 1 diabetes in affected children at diagnosis. Methods A total of 4993 children under the age of 15 years with newly diagnosed type 1 diabetes from the Finnish Pediatric Diabetes Register were recruited (56.6% boys, median age of 8.2 years) for a cross-sectional, observational, population-based investigation. The family history of diabetes at diagnosis was determined by a structured questionnaire, and markers of metabolic derangement, autoantibodies and HLA class II genetics at diagnosis were analysed. Results Two per cent of the children had an immediate family member and 36% had grandparents with type 2 diabetes. Fathers and grandfathers were affected by type 2 diabetes more often than mothers and grandmothers. The children with a positive family history for type 2 diabetes were older at the diagnosis of type 1 diabetes (p < 0.001), had higher BMI-for-age (p = 0.01) and more often tested negative for all diabetes-related autoantibodies (p = 0.02). Conclusions/interpretation Features associated with type 2 diabetes, such as higher body weight, older age at diagnosis and autoantibody negativity, are more frequently already present at the diagnosis of type 1 diabetes in children with a positive family history of type 2 diabetes. Graphical abstract

scholarly journals Diabetes onset before age 40: more and more often it is type 2 diabetes

ABOUTOPEN ◽  
2018 ◽  
Vol 4 (1) ◽  
pp. 126-128
Author(s):  
Viola Sanga
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 1 Diabetes ◽  
Family History ◽  
Young Age ◽  
Family History Of Diabetes ◽  
Diabetes Onset ◽  
History Of

An increase in the appearance of diabetes mellitus at young age is observed, and not necessarily type 1 diabetes is involced. We report the case of a 35-year-old patient, with a family history of diabetes, with type 2 diabetes at onset (Diabetology).

scholarly journals Family history of diabetes and distribution of class II HLA genotypes in children with newly diagnosed type 1 diabetes: effect on diabetic ketoacidosis

2011 ◽  
Vol 165 (5) ◽  
pp. 813-817 ◽  
Author(s):  
Anne Hekkala ◽  
Jorma Ilonen ◽  
Mikael Knip ◽  
Riitta Veijola ◽  
_ _
Keyword(s):  
Type 2 Diabetes ◽  
Type 1 Diabetes ◽  
Family History ◽  
Diabetic Ketoacidosis ◽  
Family History Of Diabetes ◽  
Hla Dr ◽  
Hla Genotypes ◽  
History Of

ObjectiveOur purpose was to assess whether family history of diabetes or the HLA-DR-DQ genotype of the index case was associated with the frequency of diabetic ketoacidosis (DKA) at diagnosis of childhood type 1 diabetes.Patients and methodsThe study cohort comprised 1518 children aged <15 years and diagnosed with type 1 diabetes in Finland in 2002–2005. Family history of type 1 and type 2 diabetes among first-degree relatives (FDRs) and grandparents was assessed at diagnosis. HLA-DR-DQ genotypes were analysed using time-resolved fluorometry.ResultsIn total, 12.6 and 1.7% of children had at least one FDR affected with type 1 or type 2 diabetes, respectively, and 6.6 and 34.8% had at least one grandparent with type 1 or type 2 diabetes. DKA (pH <7.30) occurred less frequently in children having a type 1 diabetes affected FDR (7.4 vs 20.5%, P<0.001). Type 2 diabetes among the parents or grandparents had no such effect. Lower risk HLA genotypes were observed to predispose to DKA (P<0.024). In a logistic regression analysis, the risk of DKA was independently associated with the absence of a family member affected by type 1 diabetes, the presence of a low-risk HLA genotype and older age at diagnosis (odds ratio 3.23, 1.45 and 1.07 respectively).ConclusionThe presence of type 1 diabetes in an FDR is associated with an decreased risk of DKA at diagnosis. The rate of DKA seems to be higher in children with lower HLA-conferred risk for type 1 diabetes.

scholarly journals Differential expression of micro RNA-29 family in non-diabetic adults of diabetic and non-diabetic parents

2021 ◽  
Vol 14 (1) ◽  
Author(s):  
Uzair Abbas ◽  
Bushra Imdad ◽  
Sikander Adil Mughal ◽  
Israr Ahmed Baloch ◽  
Afshan Mehboob Khan ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Family History ◽  
Positive Family History ◽  
Cross Sectional Study ◽  
Vital Role ◽  
Micro Rna ◽  
Cross Sectional ◽  
Family History Of Diabetes ◽  
History Of

Abstract Objective MicroRNAs are known to regulate 60% of genes at post translational level. MicroRNAs including Micro RNA-29 family play a vital role in cellular activities and have validate role in numerous metabolic disorders inclusive of diabetes mellitus and its complications. While micro RNA profile changes years before the occurrence of disease. This cross-sectional study was conducted in non-diabetic adults of diabetic and non-diabetic parents to explore the early changes in expression of micro RNA-29 family as it can be served as early biomarker of type 2 diabetes in non-diabetic adults. This study was conducted from January 2019 to January 2021. Micro RNA was extracted from plasma of 50 participants and expression was compared through qPCR. While data was analyzed through SPSS version 21.0. Results 29a and 29b had lower expression in participants with family history of DM compared to those having no family history of DM (P < 0.0001). While micro RNA 29c was found to be significantly higher in participants with positive family history of type 2 diabetes as compared to those without family history of diabetes (P = 0.001).

Family history of type 2 diabetes is increased in patients with type 1 diabetes

2008 ◽  
Vol 82 (1) ◽  
pp. e1-e4 ◽  
Author(s):  
B. Barone ◽  
M. Rodacki ◽  
L. Zajdenverg ◽  
M.H. Almeida ◽  
C.A. Cabizuca ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Type 1 Diabetes ◽  
Family History ◽  
History Of

Family history of Type 1 diabetes affects insulin secretion in patients with ‘Type 2’ diabetes

2013 ◽  
Vol 30 (5) ◽  
pp. e163-e169 ◽  
Author(s):  
V. M. Lundgren ◽  
M. K. Andersen ◽  
B. Isomaa ◽  
T. Tuomi
Keyword(s):  
Type 2 Diabetes ◽  
Type 1 Diabetes ◽  
Insulin Secretion ◽  
Family History ◽  
History Of

scholarly journals Potential risk factors for developing diabetes mellitus type 2

2010 ◽  
Vol 63 (3-4) ◽  
pp. 231-236 ◽  
Author(s):  
Dusica Zivanovic ◽  
Sandra Sipetic ◽  
Marina Stamenkovic-Radak ◽  
Jelena Milasin
Keyword(s):  
Risk Factors ◽  
Type 2 Diabetes ◽  
Family History ◽  
Physical Inactivity ◽  
Positive Family History ◽  
Diabetes Type 2 ◽  
Diabetes Type ◽  
Family History Of Diabetes ◽  
History Of

Introduction Type 2 diabetes mellitus is a common multifactorial genetic syndrome, which is determined by several genes and environmental factors. The aim of the present study was to investigate the presence of risk factors for developing diabetes type 2 among diabetic individuals and to compare the presence of risk factors among diabetic individuals with and without positive family history for type 2 diabetes. Material and methods This study was conducted in Cuprija during the period from February to June 2002. The case group included 137 individuals having diagnosis type 2 diabetes. The control group included 129 subjects having the following diagnoses: hypertension, angina pectoris, chronic obstructive lung disease, gastric ulcer or duodenal ulcer. All participants were interviewed at the Medical Center Cuprija using structural questionnaire. The data were collected regarding demographic characteristics, exposure to various chemical and physical agents, stress, smoking, obesity, physical inactivity and family history of diabetes. In the statistical analysis chi square test was used. Results The diabetic individuals were statistically significantly older (40 and more years old) (p=0,000), and they came from rural areas more frequently (p=0,006) than the individuals without diabetes. Significantly more diabetics had lower educational level (p=0,000) and they were agriculture workers and housewives significantly more frequently (p=0,000) than nondiabetic individuals. Furthermore, obesity (p=0,000) and physical inactivity (p=0,003) were significantly more frequent among the diabetic individuals than the nondiabetics. The diabetic individuals had significanly (p=0,000) more numbers of relatives with diabetes mellitus type 2 than the nondiabetics. The diabetic individuals with positive family history of diabetes were significantly older (p=0,021) and more frequently from urban areas (p=0,018) than the diabetic individuals without the positive family history of diabetes. Also they were significantly less exposed to physical agents (p=0,004). Discussion In our study, like in many others, age, place of residence, education, occupation, obesity, physical inactivity, positive family history of diabetes type 2 and exposure to physical agents were identified as potential risk factors for diabetes type 2. Conclusion Different risk factors are probably responsible for developing type 2 diabetes among individuals with and without positive family history of type 2 diabetes.

scholarly journals Prevalence and Family History Characteristics of Type 1 Diabetes Mellitus in Children and Adolescents: A Nigerian Tertiary-Healthcare Based Study

2020 ◽  
Vol 24 (1) ◽  
Author(s):  
Elizabeth Eberechi Oyenusi ◽  
Alphonsus Ndidi Onyiriuka ◽  
Yahaya Saidu Alkali
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Family History ◽  
Children And Adolescents ◽  
Positive Family History ◽  
Risk Category ◽  
Family History Of Diabetes ◽  
Tertiary Healthcare ◽  
History Of

Background: Family history of diabetes mellitus is a useful tool for detecting children and adolescents at risk of the disease. The aim of this study is to determine the prevalence and describe the characteristics of family history of diabetes mellitus in Nigerian children and adolescents with type 1 diabetes. Methods: A retrospective chart review of children and adolescents newly diagnosed with type 1 diabetes was conducted in three tertiary-healthcare institutions in Nigeria. In addition to the review of charts of old patients, other children and adolescents who presented with new-onset diabetes during  the review process were also included. An interviewer-administered questionnaire was used in obtaining information from the patients and their parents. Using the criteria suggested by Scheuner et al, the family history risk category was stratified into average, moderate and high. Results: Out of a total of 65 children and adolescents with type 1 diabetes, 29(44.6%, 95% CI= 32.6-56.7) had a positive family history of diabetes mellitus. Of the affected family members, 42.9% were first-degree relatives. The frequencies of family history risk category were average 65.5%, moderate 27.6% and high 6.9%. Among the affected family members in whom information on their diabetes status was available, 19(86.4%) had type 2 diabetes and only 3(13.6%) had type 1 diabetes. Conclusion: Four out of every ten patients with type 1 diabetes in the paediatric age group, have a first- degree relative with a positive family history of diabetes.

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