scholarly journals Circulating semicarbazide-sensitive amine oxidase is raised both in Type I (insulin-dependent), in Type II (non-insulin-dependent) diabetes mellitus and even in childhood Type I diabetes at first clinical diagnosis

Diabetologia ◽  
1999 ◽  
Vol 42 (2) ◽  
pp. 233-237 ◽  
Author(s):  
F. Boomsma ◽  
A. H. van den Meiracker ◽  
S. Winkel ◽  
H. J. Aanstoot ◽  
M. R. Batstra ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Clinical Diagnosis ◽  
Amine Oxidase ◽  
Type I Diabetes ◽  
Insulin Dependent Diabetes Mellitus ◽  
Dependent Diabetes Mellitus ◽  
Type I ◽  
Type Ii ◽  
Insulin Dependent ◽  
Childhood Type

scholarly journals Mechanisms of membranoreceptor function disturbances in pregnant patients with insulin-dependent diabetes mellitus

1994 ◽  
Vol 40 (4) ◽  
pp. 4-7 ◽  
Author(s):  
N P Mikaelyan ◽  
Yu. A. Knyazev ◽  
A. G. Maxina ◽  
V. A. Petrukhin
Keyword(s):  
Diabetes Mellitus ◽  
Type I Diabetes ◽  
Glucose Consumption ◽  
Insulin Dependent Diabetes Mellitus ◽  
Insulin Binding ◽  
Insulin Dependent Diabetes ◽  
Dependent Diabetes Mellitus ◽  
Type I ◽  
Functional Changes ◽  
Insulin Dependent

Studies of membranoreceptor system in patients with insulin-dependent diabetes mellitus revealed that insulin resistance in pregnant patients with type I diabetes is caused by disordered cellular sensitivity to threshold physiological and submaximal insulin doses, whereas the maximal doses of the hormone normalize glucose consumption by the cells. High insulin doses intensify lipid peroxidation, normalize the status of membranous proteins, reduce the number of thiol groups, reduce AOA level in membranes, and, hence, reduce membranous capacity to bind active peroxide radicals. Structural and functional changes in red cell membranes are associated with reduced affinity of insulin receptors, reduction in the number of insulin-binding sites in membranes, this disordering intracellular effects of insulin.

scholarly journals WORLD HEALTH DAY–DIABETES, A GROWING MENACE

2016 ◽  
Vol 2 (2) ◽  
pp. 1
Author(s):  
Sofia Shehzad
Keyword(s):  
Diabetes Mellitus ◽  
Blood Sugar ◽  
Insulin Dependent Diabetes Mellitus ◽  
Insulin Dependent Diabetes ◽  
World Health ◽  
Dependent Diabetes Mellitus ◽  
Type I ◽  
Type Ii ◽  
Insulin Dependent ◽  
Sugar Levels

World Health day, celebrated each year on 7th of April is all about creating awareness regarding health issues confronting the global population. The theme this year is Diabetes — a metabolic disorder of menacing proportion. There are a host of misconceptions and lack of understanding amongst the general public regards its exact etiology, prevention, control and socio-economic impact. As of 2015 the prevalence of the disease worldwide is estimated around 415 million affectees1. This number is expected to rise to 592 million by 2035 2. The incidence and resultant mortality secondary to this epidemic is on the rise in low and middle economy countries such as Pakistan, with the disease expected to be the 7th leading cause of death by 2030 3 . Diabetes occurs when the pancreas loses its ability to produce the required insulin or the body fails to utilize the later resulting in raised blood sugar levels 4. As a consequence, malfunctioning of various organ systems ensues and various life threatening illnesses including heart attacks, strokes, nerve damage, kidney failure, blindness, impotence and infections takes a toll on the patient's health. Broadly it is classified into 3 types - Type I or Insulin dependent diabetes mellitus also referred to as 'juvenile diabetes' in which the production of insulin is affected - Type II or Non insulin dependent diabetes mellitus characterized by insulin resistance, and having a strong correlation with increased body weight and lack of exercise 5. It is also called `adult onset 'diabetes'. - Gestational diabetes affecting pregnant women with no past history of the disease, usually in the 2Ild or 3rd trimester 6. The disease usually manifests with the symptoms of frequent urination, thirst and hunger. Once a diagnosis is made based on Blood sugar estimation and monitoring levels of glaciated hemoglobin - HbAl c, management ensues directed at achieving optimum level of blood glucose and avoiding systemic complications. This goal is achieved by introducing life style changes from a sedentary to more active and less stressful way of living, supplemented with a balanced diet and regular exercise. This is especially helpful in Type II DM. Treatment is offered by means of Oral hypoglycemic or injectable insulin as guided by the physician/endocrinologist. More recently bariatric Surgery has shown considerable promise as an effective measure to control blood sugar levels.7 This year the main objective of observing the world health day is to enhance awareness about prevention, care and surveillance of this disease. This will form the basis for launching the first ever global report on Diabetes. The core functions of WHO in this regard are as follows: - To frame internationally acceptable standards and guidelines for prevention, diagnosis and treatment of Diabetes and its associated complications - To closely monitor the morbidity and mortality associate with this disease. - Capacity building at different levels to address different aspects of this disease - To project diabetes as a global health issue and identify the population at risk Efforts to prevent and treat diabetes are essential to achieve the global sustainable development goal target of reducing premature mortality from non communicable diseases by one third by 2030. The community at large and the health care professionals and organizations in particular have a key role to play in highlighting the steps to be taken in this regard through organizing seminars and lectures and making use of the media to effectively communicate their  message to the masses.Globalhealth dayfocusing onDiabetes certainlypromises tobe akeyeventin raising awareness andproposing effective measures supplementing themanagement of this disease ona globalstage.

scholarly journals ADAPTIVE CAPACITY IMPAIRMENT IN CHILDREN WITH INSULIN-DEPENDENT DIABETES MELLITUS AS SHOWN BY TIME INTERVAL ASSESSMENT

2021 ◽  
Vol 14 (5) ◽  
pp. 112-116
Author(s):  
YURI V. BYKOV ◽  
◽  
VLADIMIR A. BATURIN ◽  
Keyword(s):  
Diabetes Mellitus ◽  
Type I Diabetes ◽  
Insulin Dependent Diabetes Mellitus ◽  
Insulin Dependent Diabetes ◽  
Dependent Diabetes Mellitus ◽  
Control Group ◽  
Study Group ◽  
Type I ◽  
Level Of Consciousness ◽  
Insulin Dependent

Aim. The aim of the study was to diagnose and study the severity of impaired adaptive capacity in children with insulin-dependent diabetes mellitus using the method of assessment of time intervals. Material and methods. The study included 54 adolescents, aged 14 to 18 years. 27 adolescents with type I diabetes mellitus, who were urgently hospitalized in the intensive care unit in a serious condition, constituted the study group, the other 27 adolescents who were hospitalized for planned surgical intervention constituted the control group (conditionally healthy children). The diagnosis of type I diabetes mellitus was confirmed by clinical and laboratory data (hyperglycemia, ketoacidosis, impaired level of consciousness (deafening-sore). Study protocol: psychophysiological testing in adolescents was performed using the original «Rhythm» program, which presented patients with a reference sequence of sound signals and pauses between them, after which the patients played back the sound sequence using a personal computer. Adolescents in the study group were tested after diabetic ketoacidosis had subsided, glycemia had stabilized, and the level of consciousness had normalized (3–5 days after admission). The control group was tested upon admission to thehospital for planned treatment. Significance of the total index of deviations from the specified reference was determined using Student’s t-criterion. Results and discussion. Significant adaptation disorders were detected both in the study group and in the control group. However, in children with diabetes mellitus these disorders were more pronounced due to a greater shortening of the total duration of the cycle, as well as a greater aggregate index of deviations from the duration of set signals and pauses as compared to the «reference standard». Conclusion. The findings support the hypothesis that impaired adaptation mechanisms as a manifestation of desynchronization of biological rhythms may lie in the mechanism of insulin-dependent diabetes mellitus development.

Hyperglycemia following Intralesional Corticosteroid Injection in a Patient with Type I Diabetes Mellitus

2014 ◽  
Vol 18 (4) ◽  
pp. 275-276 ◽  
Author(s):  
Patrick Fleming ◽  
Leah Drazek ◽  
James C. Shaw
Keyword(s):  
Diabetes Mellitus ◽  
Type I Diabetes ◽  
Corticosteroid Injection ◽  
Insulin Dependent Diabetes Mellitus ◽  
Local Effect ◽  
Dependent Diabetes Mellitus ◽  
Type I ◽  
Systemic Complications ◽  
Intralesional Corticosteroid ◽  
Insulin Dependent

Case Report: A 36-year-old woman with well-controlled type 1 diabetes mellitus reported hyperglycemia (plasma glucose peaked at 21.3 mmol/L) after her first injection with intralesional triamcinolone acetonide for alopecia areata. Conclusion: Intralesional corticosteroids are used to maximize local effect while presumably minimizing systemic complications. This adverse effect is an important consideration when treating patients with insulin-dependent diabetes mellitus, and it would be reasonable to counsel patients of such a possibility.

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