Neuromuscular Blockade Does Not Decrease Oxygen Consumption or Energy Expenditure Beyond Sedation in the Mechanically Ventilated Child

1997 ◽  
Vol 12 (6) ◽  
pp. 321-323
Author(s):  
Robert L. Sheridan ◽  
Kathy Prelack ◽  
Stanislaw K. Szyfelbein
Keyword(s):  
Carbon Dioxide ◽  
Oxygen Consumption ◽  
Energy Expenditure ◽  
Neuromuscular Blockade ◽  
The Body ◽  
Controlled Study ◽  
Average Weight ◽  
Mechanically Ventilated ◽  
Significant Difference ◽  
Expired Gas

Minimizing the high oxygen consumption and energy expenditure of the critically ill is an important therapeutic goal. This study was done to determine if neuromuscular blockade decreases oxygen consumption or energy expenditure more than sedation alone in the mechanically ventilated child. Twelve burned children, with an average age of 5.1- 1.6 yrs, average weight of 22.8 − 6.5 kg, and average burn size of 28.3 − 5.8% of the body surface, scheduled for a planned surgical procedure under general anesthesia were enrolled in this prospective self-controlled study. In conjunction with planned operative procedures and using an intravenous anesthetic technique, the children underwent expired gas collection before and after neuromuscular blockade was induced. Expired gas was collected and analyzed for the fractional concentration of oxygen and carbon dioxide. Oxygen consumption (VO2), carbon dioxide production (VCO2), energy expenditure (EE), and respiratory quotient (RQ) were calculated. We found no significant difference in EE, VO2, VCO2, or RQ between the well-sedated and mechanically ventilated and the well-sedated, mechanically ventilated and paralyzed states. We therefore concluded that neuromuscular blockade does not decrease energy expenditure in the otherwise well-sedated burned child.

Measurement of ‘Basal’ and Total Metabolism in Hereditarily Obese-Hyperglycemic Mice

1958 ◽  
Vol 193 (3) ◽  
pp. 495-498 ◽  
Author(s):  
Ruth McClintock ◽  
Nathan Lifson
Keyword(s):  
Carbon Dioxide ◽  
Oxygen Consumption ◽  
Energy Expenditure ◽  
Voluntary Movement ◽  
Carbon Dioxide Production ◽  
Open Circuit ◽  
Energy Output ◽  
Obese Mice ◽  
Energy Expenditures ◽  
Isotope Method

Measurements of oxygen consumption and carbon dioxide production were made by the Haldane open circuit method on hereditarily obese mice and littermate controls, and the energy expenditures were estimated. Studies were made on mice for short periods under ‘basal’ conditions, and for periods of approximately a day with the mice fasted and confined, fasted and relatively unconfined, and fed and unconfined. The total energy expenditures of fed and unconfined obese mice were found to be higher than those of nonobese littermate controls by virtue of a) increased ‘basal metabolism’, b) greater energy expenditure associated with feeding, and possibly c) larger energy output for activity despite reduced voluntary movement. The values obtained for total metabolism confirm those previously determined by an isotope method for measuring CO2 output.

scholarly journals The effect of red-fleshed pitaya (Hylocereus polyrhizus) on heat shock protein 70 and cortisol expression in strenuous exercise induced rats

F1000Research ◽  
2019 ◽  
Vol 8 ◽  
pp. 130
Author(s):  
Novita Sari Harahap ◽  
Aznan Lelo ◽  
Ambrosius Purba ◽  
Awaluddin Sibuea ◽  
Rina Amelia ◽  
...  
Keyword(s):  
Body Weight ◽  
Heat Shock ◽  
Heat Shock Protein ◽  
Heat Shock Protein 70 ◽  
The Body ◽  
Male Rats ◽  
Strenuous Exercise ◽  
Hsp70 Expression ◽  
Average Weight ◽  
Significant Difference

Background: Oxidative stress from exercise can contribute to damaging cells, increasing heat shock protein 70 (HSP70) and suppressing the immune system in the body. This research aimed to determine the antioxidant potential of red-fleshed pitaya extract on HSP70 and cortisol expression in rats which were subjected to strenuous exercise. Methods: The subjects of this research were 32 Sprague Dawley male rats, aged 3 months, with an average weight of 200 g. Red-fleshed pitaya extract was obtained from methanol extraction process; a maceration technique was performed and the extract was concentrated using an air-drying method. Rats were randomly divided into four groups. Group 1 were subjected to strenuous exercise and treated with distilled water only; while Groups 2, 3 and 4 were subjected to strenuous exercise and treated with 100 mg/kg body weight, 200 mg/kg body weight and 300 mg/kg body weight of red-fleshed pitaya extract, respectively. Strenuous exercises in rats was performed by intense swimming of 20 min/day, 3 days a week for 3 weeks. HSP70 expression and cortisol were measured with Enzyme-Linked Immune Sorbent Assay (ELISA) method. Results: There was a significant reduction of HSP70 (p=0.000) and cortisol expression (p=0.000) between the groups. Also, there was a significant difference in the average decreasing of HSP70 expression between group 4 and either groups 1 or 2 (p=0.000). However, a significant difference between groups 4 and 3 was not observed (p=0.813). Lastly, a significant difference was found in the average decrease of cortisol expression between groups 4 and 1 (p=0.000), 2 (p=0.000), and 3 (p=0.000) respectively. Conclusion: Red-fleshed pitaya is potential to be utilized as antioxidant to decrease the HSP70 and cortisol expression.

scholarly journals COMPARISON OF EPOC AND RECOVERY ENERGY EXPENDITURE BETWEEN HIIT AND CONTINUOUS AEROBIC EXERCISE TRAINING

2019 ◽  
Vol 25 (1) ◽  
pp. 20-23 ◽  
Author(s):  
Mateus Ahlert ◽  
Fernando Matzenbacher ◽  
José Carlos dos Santos Albarello ◽  
Gustavo Henrique Halmenschlager
Keyword(s):  
Oxygen Consumption ◽  
Energy Expenditure ◽  
Aerobic Exercise ◽  
Maximal Oxygen Consumption ◽  
Aerobic Exercise Training ◽  
Fat Percentage ◽  
Level Of Evidence ◽  
Cross Sectional ◽  
Significant Difference ◽  
High Intensity Interval

ABSTRACT Objectives: The objective of this study was to compare EPOC - excess post-exercise oxygen consumption and recovery energy expenditure between high intensity interval aerobic exercise (HIIT) and continuous aerobic exercise in adult amateur runners. Methods: The study included 10 runners, with a mean age of 35.7 ± 5.87 years, height 1.69 ± 0.11 m; body mass 74.13 ± 11.26 kg; fat percentage 19.31 ± 4.27% and maximal oxygen consumption (VO2max) of 3.50 ± 0.64 l/kg/min-1. The continuous aerobic exercise protocol consisted of 20 minutes of running with intensity of 70-75% HRmax. Two 20-second cycles of 8 sprints were performed for HIIT at the highest possible speed, with 10 seconds of rest and a 3-minute interval between cycles. The sample group performed the two protocols at least 48 hours and at most one week apart. EPOC was observed using ergospirometry after the running protocols, and mean consumption was analyzed between 25-30 minutes after exercise. Oxygen consumption at 9-10 minutes was used for resting consumption. The study has a cross-sectional experimental design. Results: Oxygen consumption of 0.57 ± 0.29l/kg/min1 and energy expenditure of 2.84 ± 1.44 kcal/min were observed for continuous aerobic exercise, with values of 0.61 ± 0.62 l/kg/min−1 and 3.06 ± 1.10 kcal/min respectively (p <0.05) for HIIT. Conclusion: The protocols performed did not show a statistically significant difference in terms of EPOC and energy expenditure, but the performance of HIIT increased lipid metabolism for exercise recovery, which may favor the weight loss process. Moreover, this activity model takes up less time. Level of evidence I, randomized clinical trial.

Combined heart rate and activity improve estimates of oxygen consumption and carbon dioxide production rates

1996 ◽  
Vol 81 (4) ◽  
pp. 1754-1761 ◽  
Author(s):  
Jon K. Moon ◽  
Nancy F. Butte
Keyword(s):  
Carbon Dioxide ◽  
Heart Rate ◽  
Oxygen Consumption ◽  
Energy Expenditure ◽  
Carbon Dioxide Production ◽  
Alternative Methods ◽  
Prediction Errors ◽  
Nonlinear Functions ◽  
Production Rates ◽  
Basal Energy Expenditure

Moon, Jon K., and Nancy F. Butte. Combined heart rate and activity improve estimates of oxygen consumption and carbon dioxide production rates. J. Appl. Physiol.81(4): 1754–1761, 1996.—Oxygen consumption (V˙o 2) and carbon dioxide production (V˙co 2) rates were measured by electronically recording heart rate (HR) and physical activity (PA). Mean daily V˙o 2 andV˙co 2 measurements by HR and PA were validated in adults ( n = 10 women and 10 men) with room calorimeters. Thirteen linear and nonlinear functions of HR alone and HR combined with PA were tested as models of 24-h V˙o 2 andV˙co 2. Mean sleepV˙o 2 andV˙co 2 were similar to basal metabolic rates and were accurately estimated from HR alone [respective mean errors were −0.2 ± 0.8 (SD) and −0.4 ± 0.6%]. The range of prediction errors for 24-h V˙o 2 andV˙co 2 was smallest for a model that used PA to assign HR for each minute to separate active and inactive curves (V˙o 2, −3.3 ± 3.5%; V˙co 2, −4.6 ± 3%). There were no significant correlations betweenV˙o 2 orV˙co 2 errors and subject age, weight, fat mass, ratio of daily to basal energy expenditure rate, or fitness. V˙o 2,V˙co 2, and energy expenditure recorded for 3 free-living days were 5.6 ± 0.9 ml ⋅ min−1 ⋅ kg−1, 4.7 ± 0.8 ml ⋅ min−1 ⋅ kg−1, and 7.8 ± 1.6 kJ/min, respectively. Combined HR and PA measured 24-h V˙o 2 andV˙co 2 with a precision similar to alternative methods.

Efficiency of correction of autonomic disorders in the conditions of meteo-climatic maladaptation by the methods of reflex and crystal therapy

2015 ◽  
Vol 9 (4) ◽  
pp. 0-0
Author(s):  
Михайлова ◽  
A. Mikhaylova ◽  
Круглянин ◽  
K. Kruglyanin ◽  
Файзуллоев ◽  
...  
Keyword(s):  
Nervous System ◽  
Environmental Changes ◽  
Climatic Conditions ◽  
The Body ◽  
Controlled Study ◽  
Health Improvement ◽  
Control Group ◽  
Vegetative Nervous System ◽  
Significant Difference ◽  
Autonomic Disorders

The change of climatic conditions often leads to stress and sometimes failure of adaptive resources. Vegetative nervous system is one of the main participants of adaptation to environmental changes. Its functions inevitably decline in cases of short-term change of meteorological and climatic conditions, especially, in people with history of vascular dystonia. The article presents the results of correction of the autonomic function by the methods of reflex- and crystal therapy in the conditions of maladaptation due to meteo-climatic changes. Due to its popularization in world medical practice and absence of research within evidence-based medicine, non-drug therapy, used in complementary medicine, in particular crystal therapy, require evaluation of its effectiveness for correction of autonomic disorders in cases of maladaptation and comparing with the generally accepted method of reflexology. Crystal therapy is a method of health improvement, which involves applying precious and semiprecious minerals to various parts of the body. Assessment of vegetative nervous system in healthy men and women with the diagnosis of vascular dystonia was carried out on the first day and 7-8 days after the arrival to Anapa. Randomized, blind, placebo controlled study has shown significant difference of the effect of reflex- and crystal therapy from the control group and the placebo group, in the correction of vegetative disturbances according to the heart rate variability and a number of mental health indicators. It has proven the effectiveness of reflexotherapy in the case of a high degree of maladaptation and crystal therapy in case of mild to moderate severity of maladaptation, identified according to the coefficient of weather variability in traffic along various routes.

Continuous Arterial PO(2) and PCO(2) Measurements in Swine during Nitrous Oxide and Xenon Elimination 

1999 ◽  
Vol 90 (3) ◽  
pp. 829-834 ◽  
Author(s):  
Enrico Calzia ◽  
Wolfgang Stahl ◽  
Thomas Handschuh ◽  
Thomas Marx ◽  
Gebhardt Froba ◽  
...  
Keyword(s):  
Carbon Dioxide ◽  
Nitrous Oxide ◽  
Oxygen Tension ◽  
Arterial Oxygen Tension ◽  
Gas Mixtures ◽  
Arterial Oxygen ◽  
Mechanically Ventilated ◽  
Significant Difference ◽  
Blood Solubility ◽  
Xenon Washout

Background During nitrous oxide (N2O) elimination, arterial oxygen tension (PaO2) decreases because of the phenomenon commonly called diffusive hypoxia. The authors questioned whether similar effects occur during xenon elimination. Methods Nineteen anesthetized and paralyzed pigs were mechanically ventilated randomly for 30 min using inspiratory gas mixtures of 30% oxygen and either 70% N2O or xenon. The inspiratory gas was replaced by a mixture of 70% nitrogen and 30% oxygen. PaO2 and carbon dioxide tensions were recorded continuously using an indwelling arterial sensor. Results The PaO2 decreased from 119+/-10 mm Hg to 102+/-12 mm Hg (mean+/-SD) during N2O washout (P&lt;0.01) and from 116+/-9 mm Hg to 110+/-8 mm Hg during xenon elimination (P&lt;0.01), with a significant difference (P&lt;0.01) between baseline and minimum PaO2 values (deltaPaO2, 17+/-6 mm Hg during N2O washout and 6+/-3 mm Hg during xenon washout). The PaCO2 value also decreased (from 39.3+/-6.3 mm Hg to 37.6+/-5.8 mm Hg) during N2O washout (P&lt;0.01) and during xenon elimination (from 35.4+/-1.6 mm Hg to 34.9+/-1.6 mm Hg; P&lt; 0.01). The deltaPaCO2 was 1.7+/-0.9 mm Hg in the N2O group and 0.5+/-0.3 mm Hg in the xenon group (P&lt;0.01). Conclusion Diffusive hypoxia is unlikely to occur during recovery from xenon anesthesia, probably because of the low blood solubility of this gas.

scholarly journals High-risk pregnancy: effectiveness of personalized pregravid preparation and positive perinatal experience

2021 ◽  
pp. 34-41
Author(s):  
G.S. Manasova ◽  
N.V. Didenkul ◽  
N.V. Kuzmyn
Keyword(s):  
First Trimester ◽  
Evidence Base ◽  
Cross Sectional Study ◽  
Convincing Evidence ◽  
Controlled Study ◽  
Average Weight ◽  
Cross Sectional ◽  
Planning Stage ◽  
Risk Pregnancy ◽  
Significant Difference

Research objective: to study the possibilities of improving perinatal results by optimizing pergravid preparation in women with high perinatal risk.Materials and methods. The first stage – a cross-sectional study – consisted in determining the vitamin D (VD) status and assessing the course of pregnancy in 459 women in the II and III trimester; the second stage was a randomized controlled study of women with VD deficiency in group IIA (planning stage, 54 women) and IIB (I trimester, 60 women), who received the vitamin and mineral complex (VMC) Pregna-5 with a high calcitriol content and perinatal results were evaluated. VD in the blood was determined by the enzyme-linked immunosorbent assay.Results. VD level was optimal only in 30.7% of pregnant women (group ІА), in 69.3% of women its insufficiency or deficiency was found (group ІB). The frequency of threatened termination (9.9 vs. 45.6%; p < 0.01), preeclampsia (2.0 vs. 11%; p < 0.05), intrauterine growth retardation (7% only in group IIB, p < 0.01) was significantly higher against the background of BD deficiency. Normalization of the VD level (groups IIA and IIB) after VMC administration was observed within 1–3 months. Pregnancy complications value was higher in the group where the VMC was started in the first trimester: early gestosis (15 vs. 28.57%; p < 0.05), the threat of termination (22.2 vs. 36.7%; p < 0.05), bacterial vaginosis (7.4 vs. 31.7%; p < 0.05), placental dysfunction (18.5 vs. 40.0%; p <0.01), placental pathology in group IIB was detected 2–3 times more often. The differences between the preeclampsia (1.9 vs. 6.7%; p > 0.05) and anemia (16.6 vs. 28.3%; p > 0.05) were insignificant. Analysis of the childbirth results showed a significantly higher frequency of cesarean sections in group IIB (38.3 vs. 22.2%; p < 0.05), the average weight of newborns was less (3299.11 ± 128 g vs. 3643.24 ± 136 g; p < 0.01). The most effective was the VMC start at the stage of pregnancy planning (F = 13.35482; p = 0.000016); a significant difference was revealed in the course of pregnancy in the groups where VMC started in the first, second and third trimesters of pregnancy (Q = 4.67, p = 0.00458).Conclusions. Timely donation of VMC with a high content of cholecalciferol in women with high perinatal risk may lead to a positive course of pregnancy. Further research is required to obtain a convincing evidence base.

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