As an important Solid Free Form Fabrication (SFF) technology, three-dimensional printing (3DP) has become popular in applications due to its properties of rapid prototyping, no pollution, and high productivity. Based on the experiment platform of ZP310, this paper investigates that powder layer thickness and blinder saturation level for different location of parts placement have effect on the part surface topography and forming accuracy, the location of parts placement includes right, middle and left, respectively, which represents the different face contact to the bottom of manufacturing box. The experiments show that: when the left of part is placed to contact to the bottom of manufacturing box, the powder layer thickness is 0.1 mm and the binder saturation level is 70%, the best surface topography can be obtained.