Systemic treatment with strontium ranelate promotes tibial fracture healing in ovariectomized rats

2009 ◽  
Vol 21 (11) ◽  
pp. 1889-1897 ◽  
Author(s):  
Y. F. Li ◽  
E. Luo ◽  
G. Feng ◽  
S. S. Zhu ◽  
J. H. Li ◽  
...  
Keyword(s):  
Fracture Healing ◽  
Strontium Ranelate ◽  
Tibial Fracture ◽  
Systemic Treatment ◽  
Ovariectomized Rats

scholarly journals Cumulative Effects Of Strontium Ranelate and Impact Exercise On Bone Mass In Ovariectomized Rats

2021 ◽  
Vol 22 (6) ◽  
pp. 3040
Author(s):  
Priscilla Aveline ◽  
Annabelle Cesaro ◽  
Marija Mazor ◽  
Thomas M. Best ◽  
Eric Lespessailles ◽  
...  
Keyword(s):  
Bone Mineral ◽  
Fat Mass ◽  
Lipid Content ◽  
Strontium Ranelate ◽  
Bending Test ◽  
Ovariectomized Rats ◽  
Whole Body ◽  
Left Femur ◽  
Osteocyte Apoptosis ◽  
Ovx Rats

OBJECTIVE: To explore the effect of physical exercise (EXE), strontium ranelate (SR), or their combination on bone status in ovariectomized (OVX) rats. DESIGN: Sixty female Wistar rats were randomized to one of five groups: sham (Sh), OVX (O), OVX+EXE (OE), OVX+SR (OSR), and OVX+EXE+SR (OESR). Animals in EXE groups were subjected to 10 drops per day (45 cm in height); rats in SR groups received 625 mg/kg/day of SR, 5 days/week for 8 weeks. Bone mineral density (BMD) and bone mineral content (BMC, dual-energy X-ray absorptiometry (DXA)), mechanical strength of the left femur (three-point bending test), and femur microarchitecture of (micro-computed tomography imaging, microCT) analyses were performed to characterize biomechanical and trabecular/cortical structure. Bone remodeling, osteocyte apoptosis, and lipid content were evaluated by ELISA and immunofluorescence tests. RESULTS: In OVX rats, whole-body BMD, trabecular parameters, and osteocalcin (OCN) levels decreased, while weight, lean/fat mass, osteocyte apoptosis, and lipid content all increased. EXE after ovariectomy improved BMD and BMC, trabecular parameters, cross-sectional area (CSA), moment of inertia, and OCN levels while decreasing osteocyte apoptosis and lipid content. SR treatment increased BMD and BMC, trabecular parameters, CSA, stiffness, OCN, and alkaline phosphatase (ALP) levels. Furthermore, fat mass, N-telopeptide (NTX) level, osteocyte apoptosis, and lipid content significantly decreased. The combination of both EXE and SR improved bone parameters compared with EXE or SR alone. CONCLUSION: EXE and SR had positive and synergistic effects on bone formation and resorption.

scholarly journals Different doses of strontium ranelate and mechanical vibration modulate distinct responses in the articular cartilage of ovariectomized rats

2017 ◽  
Vol 25 (7) ◽  
pp. 1179-1188 ◽  
Author(s):  
A.G.H. Mierzwa ◽  
J.F. Campos ◽  
M.F. Jesus ◽  
H.B. Nader ◽  
M. Lazaretti-Castro ◽  
...  
Keyword(s):  
Articular Cartilage ◽  
Strontium Ranelate ◽  
Mechanical Vibration ◽  
Ovariectomized Rats ◽  
Different Doses

Natural frequency of fracture fragments in the assessment of tibial fracture healing

1984 ◽  
Vol 6 (3) ◽  
pp. 227-229 ◽  
Author(s):  
L.D.M. Nokes ◽  
W.J. Mintowt-Czyzt ◽  
J.A. Fairclough ◽  
I. Mackie ◽  
C. Howard ◽  
...  
Keyword(s):  
Fracture Healing ◽  
Natural Frequency ◽  
Tibial Fracture

scholarly journals The Effect of Strontium Ranelate on Fracture Healing: An Animal Study

2020 ◽  
Vol 2020 ◽  
pp. 1-9
Author(s):  
Ourania I. Koukou ◽  
Lampros D. Pappas ◽  
Pelagia Chloropoulou ◽  
Maria A. Kouroupi ◽  
Konstantinos I. Koukos ◽  
...  
Keyword(s):  
Treatment Group ◽  
Fracture Healing ◽  
Strontium Ranelate ◽  
Fibrous Tissue ◽  
Rabbit Model ◽  
Control Group ◽  
Biomechanical Assessment ◽  
Osteoclast Number ◽  
Histopathological Studies ◽  
Area Percentage

Background. Strontium ranelate (StR) is an antiosteoporotic agent previously utilized for the enhancement of fracture union. We investigated the effects of StR on fracture healing using a rabbit model. Methods. Forty adult female rabbits were included in the study and were divided in 2 equal groups, according to StR treatment or untreated controls. All animals were subjected to osteotomy of the ulna, while the contralateral ulna remained intact and served as a control for the biomechanical assessment of fracture healing. Animals in the study group received 600 mg/kg/day of StR orally. All animals received ordinary food. At 2 and 4 weeks, all animals were euthanatized and the osteotomy sites were evaluated for healing through radiological, biomechanical, and histopathological studies. Results. The treatment group presented statistically significant higher callus diameter, total callus area, percentage of fibrous tissue ( p < 0.001 ), vessels/mm2, number of total vessels, and lower osteoclast number/mm2 ( p < 0.05 ) than the control group at 2 weeks. Additionally, the treatment group presented significantly higher percentages of new trabecular bone, vessels/mm2, osteoclast number/mm2, and lower values for callus diameter, as well as total callus area ( p < 0.05 ), than the control group at 4 weeks. At 4 weeks, in the treatment group, force applied ( p = 0.003 ), energy at failure ( p = 0.004 ), and load at failure ( p = 0.003 ) were all significantly higher in the forearm specimens with the osteotomized ulnae compared to those without. Radiological bone union was demonstrated for animals receiving StR at 4 weeks compared with controls ( p = 0.045 ). Conclusion. StR appears to enhance fracture healing but further studies are warranted in order to better elucidate the mechanisms and benefits of StR treatment.

Simvastatin promotes femoral fracture healing in ovariectomized rats

Bone ◽  
2010 ◽  
Vol 47 ◽  
pp. S396
Author(s):  
Liu Zhang ◽  
Fa-ming Tian ◽  
Yang Luo
Keyword(s):  
Fracture Healing ◽  
Femoral Fracture ◽  
Ovariectomized Rats
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