scholarly journals Early effects of parathyroid hormone on bisphosphonate/steroid-associated compromised osseous wound healing

2013 ◽  
Vol 25 (3) ◽  
pp. 1141-1150 ◽  
Author(s):  
S. Kuroshima ◽  
P. Entezami ◽  
L. K. McCauley ◽  
J. Yamashita
Keyword(s):  
Wound Healing ◽  
Parathyroid Hormone ◽  
Early Effects

Early Effects of Parathyroid Hormone and Thyrocalcitonin on Bone in Organ Culture

Nature ◽  
1967 ◽  
Vol 214 (5087) ◽  
pp. 486-487 ◽  
Author(s):  
LAWRENCE G. RAISZ ◽  
INGRID NIEMANN
Keyword(s):  
Parathyroid Hormone ◽  
Organ Culture ◽  
Early Effects

Early Effects of Parathyroid Hormone on Rat Calvarian Bone Alkaline Phosphatase

Endocrinology ◽  
1978 ◽  
Vol 103 (5) ◽  
pp. 1573-1578 ◽  
Author(s):  
J. McPARTLIN ◽  
P. SKRABANEK ◽  
D. POWELL
Keyword(s):  
Alkaline Phosphatase ◽  
Parathyroid Hormone ◽  
Bone Alkaline Phosphatase ◽  
Early Effects

scholarly journals Early effects of atorvastatin on Vitamin D and parathyroid hormone serum levels following acute myocardial infarction

2019 ◽  
Vol 8 (1) ◽  
pp. 7
Author(s):  
Ali Moradi ◽  
Batool Zarei ◽  
Maryam Mousavi ◽  
Saeideh Mehdizadeh ◽  
Hassan Mehrad-Majd ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Vitamin D ◽  
Parathyroid Hormone ◽  
Serum Levels ◽  
Early Effects

Inhibition of net calcium efflux from bone by ethanol in vitro

1984 ◽  
Vol 246 (1) ◽  
pp. C30-C36 ◽  
Author(s):  
W. K. Ramp ◽  
D. N. Demaree
Keyword(s):  
Parathyroid Hormone ◽  
Inorganic Phosphate ◽  
Lactate Production ◽  
Chick Embryos ◽  
Calcium Efflux ◽  
Suckling Rats ◽  
Consistent Effect ◽  
Early Effects ◽  
Net Fluxes

Ethanol administered to animals is known to cause hypocalcemia. This investigation was undertaken to evaluate direct early effects of ethanol on the net fluxes of Ca2+ and inorganic phosphate (Pi) into or out of bone using tibiae from 13-day-old chick embryos and 8-day-old suckling rats in vitro. When chick bones were incubated with ethanol in the medium (10 microliters/ml), net Ca2+ efflux was decreased 19, 22, 27, and 31% at 2, 4, 6, and 8 h, respectively. Metabolically inhibited bones showed a net influx rather than efflux of Ca2+ and were not further affected by ethanol. The ethanol had no consistent effect on net Pi efflux and slightly reduced lactate production. At three doses of ethanol (3, 10, and 30 microliters/ml of medium) the reduction of Ca2+ efflux was dose related in both chick and rat bones. Ethanol completely inhibited parathyroid hormone-stimulated, net Ca2+ efflux from chick bones, even at ethanol levels that by themselves did not affect Ca2+ efflux. These findings are consistent with the hypothesis that the hypocalcemia in ethanol-treated animals may be due in part to inhibition of net Ca2+ efflux from bone.

scholarly journals Different effects of Wnt/β-catenin activation and PTH activation in adult and aged male mice metaphyseal fracture healing

2020 ◽  
Author(s):  
Daocheng Liu ◽  
Hao Qin ◽  
Jiazhi Yang ◽  
Lei Yang ◽  
Sihao He ◽  
...  
Keyword(s):  
Parathyroid Hormone ◽  
Fracture Healing ◽  
Signaling Pathway ◽  
Tartrate Resistant Acid Phosphatase ◽  
Mrna Levels ◽  
Wild Type ◽  
Long Term Effects ◽  
Femoral Metaphysis ◽  
Related Transcription Factor ◽  
Early Effects

Abstract Background: Fractures in older men are not uncommon and need to be healed as soon as possible to avoid related complications. Anti-osteoporotic drugs targeting Wnt/β-catenin and PTH (parathyroid hormone) to promote fracture healing have become an important direction in recent years.Objective: Observe whether there is a difference in adult and aged situations by activating two signal paths.Methods: A single cortical hole with a diameter of 0.6 mm was made in the femoral metaphysis of Catnblox(ex3) mice and wild-type mice. The fracture healing effects of CA(Wnt/β-catenin activation) and PTH (activated by PTH (1–34) injections) were assessed by X-ray and CT imaging on days 7, 14, and 21 after fracture. The mRNA levels of β-catenin, PTH1R(Parathyroid hormone 1 receptor), and RUNX2(Runt-related transcription factor 2) in the fracture defect area were detected using RT-PCR. Angiogenesis and osteoblasts were observed by immunohistochemistry and osteoclasts were observed by TRAP (Tartrate-resistant Acid Phosphatase).Result: Adult CA mice and adult PTH mice showed slightly better fracture healing than adult wild-type (WT) mice, but there was no statistical difference. Aged CA mice showed better promotion of angiogenesis and osteoblasts and better fracture healing than aged PTH mice.Conclusion: The application of Wnt/β-catenin signaling pathway drugs for fracture healing in elderly patients may bring better early effects than PTH signaling pathway drugs, but the long-term effects need to be observed.

scholarly journals Spatial and Temporal Expression of Parathyroid Hormone-Related Protein during Wound Healing

1999 ◽  
Vol 112 (5) ◽  
pp. 788-795 ◽  
Author(s):  
Eric A.G. Blomme ◽  
Charles C. Capen ◽  
Thomas J. Rosol ◽  
Hong Zhou ◽  
Vicky Kartsogiannis
Keyword(s):  
Wound Healing ◽  
Parathyroid Hormone ◽  
Related Protein ◽  
Temporal Expression ◽  
Parathyroid Hormone Related Protein
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