Lack of maternal dietary exposure effects of bisphenol A and nonylphenol during the critical period for brain sexual differentiation on the reproductive/endocrine systems in later life

2004 ◽  
Vol 78 (2) ◽  
pp. 97-105 ◽  
Author(s):  
Masao Hirose ◽  
Hironori Takagi ◽  
Makoto Shibutani ◽  
Naoya Masutomi ◽  
Chikako Uneyama ◽  
...  
Keyword(s):  
Bisphenol A ◽  
Sexual Differentiation ◽  
Critical Period ◽  
Dietary Exposure ◽  
Later Life ◽  
Brain Sexual Differentiation ◽  
Reproductive Endocrine

scholarly journals Evidence of Altered Brain Sexual Differentiation in Mice Exposed Perinatally to Low, Environmentally Relevant Levels of Bisphenol A

Endocrinology ◽  
2006 ◽  
Vol 147 (8) ◽  
pp. 3681-3691 ◽  
Author(s):  
Beverly S. Rubin ◽  
Jenny R. Lenkowski ◽  
Cheryl M. Schaeberle ◽  
Laura N. Vandenberg ◽  
Paul M. Ronsheim ◽  
...  
Keyword(s):  
Sex Differences ◽  
Bisphenol A ◽  
Brain Development ◽  
Sexual Differentiation ◽  
Female Offspring ◽  
Sexually Dimorphic ◽  
Critical Periods ◽  
Neuron Number ◽  
Brain Sexual Differentiation ◽  
Estrogenic Chemical

Humans are routinely exposed to bisphenol A (BPA), an estrogenic chemical present in food and beverage containers, dental composites, and many products in the home and workplace. BPA binds both classical nuclear estrogen receptors and facilitates membrane-initiated estrogenic effects. Here we explore the ability of environmentally relevant exposure to BPA to affect anatomical and functional measures of brain development and sexual differentiation. Anatomical evidence of alterations in brain sexual differentiation were examined in male and female offspring born to mouse dams exposed to 0, 25, or 250 ng BPA/kg body weight per day from the evening of d 8 of gestation through d 16 of lactation. These studies examined the sexually dimorphic population of tyrosine hydroxylase (TH) neurons in the rostral periventricular preoptic area, an important brain region for estrous cyclicity and estrogen-positive feedback. The significant sex differences in TH neuron number observed in control offspring were diminished or obliterated in offspring exposed to BPA primarily because of a decline in TH neuron number in BPA-exposed females. As a functional endpoint of BPA action on brain sexual differentiation, we examined the effects of perinatal BPA exposure on sexually dimorphic behaviors in the open field. Data from these studies revealed significant sex differences in the vehicle-exposed offspring that were not observed in the BPA-exposed offspring. These data indicate that BPA may be capable of altering important events during critical periods of brain development.

Androgen receptors exist throughout the ‘critical period’ of brain sexual differentiation

Nature ◽  
1979 ◽  
Vol 282 (5736) ◽  
pp. 308-310 ◽  
Author(s):  
Christine C. Vito ◽  
Steven J. Wieland ◽  
Thomas O. Fox
Keyword(s):  
Sexual Differentiation ◽  
Critical Period ◽  
Androgen Receptors ◽  
Brain Sexual Differentiation

Delayed onset of puberty in male offspring from bisphenol A-treated dams is followed by the modulation of gene expression in the hypothalamic–pituitary–testis axis in adulthood

2017 ◽  
Vol 29 (12) ◽  
pp. 2496 ◽  
Author(s):  
Isabela M. Oliveira ◽  
Renata M. Romano ◽  
Patricia de Campos ◽  
Monica D. Cavallin ◽  
Claudio A. Oliveira ◽  
...  
Keyword(s):  
Estrogen Receptor ◽  
Bisphenol A ◽  
Mrna Expression ◽  
Sexual Differentiation ◽  
Later Life ◽  
World Health ◽  
Control Group ◽  
Adult Rats ◽  
Endocrine Disrupting Chemical ◽  
Hpt Axis

Bisphenol A (BPA) is a synthetic endocrine-disrupting chemical of high prevalence in the environment, which may affect the function of the hypothalamic–pituitary–testis (HPT) axis in adult rats. The aim of the present study was to evaluate whether exposure to BPA during hypothalamic sexual differentiation at doses below the reproductive no observable adverse effect level of the World Health Organization causes changes in the regulation of the HPT axis. For this, 0.5 or 5 mg kg−1 BPA was injected subcutaneously to the mothers from gestational day 18 to postnatal day (PND) 5. In adulthood (PND90), the mRNA expression of genes related to HPT axis was evaluated in hypothalamus, pituitary and testis. Hypothalamic expression of gonadotrophin-releasing hormone (Gnrh) and estrogen receptor 2 (Esr2) mRNA was increased in both BPA-treated groups compared to control group. In the pituitary, follicle stimulating hormone beta subunit (Fshb) and androgen receptor (Ar) mRNA expression was increased compared to control group in rats treated with 0.5 mg kg−1 of BPA, whereas estrogen receptor 1 (Esr1) mRNA expression was only increased in the group treated with 5 mg kg−1 of BPA, compared to control group. In the testis, there was increased expression of FSH receptor (Fshr) and inhibin beta B subunit (Inhbb) transcripts only in rats treated with 0.5 mg kg−1 of BPA. Serum testosterone and LH concentrations were increased in the group treated with 5 mg kg−1 of BPA. The results of the present study demonstrate for the first time that perinatal exposure to low doses of BPA during the critical period of hypothalamic sexual differentiation modifies the activity of the HPT axis in the offspring, with consequences for later life in adult rats.

scholarly journals Twenty-Four Hour Human Urine and Serum Profiles of Bisphenol A during High-Dietary Exposure

2011 ◽  
Vol 123 (1) ◽  
pp. 48-57 ◽  
Author(s):  
Justin G. Teeguarden ◽  
Antonia M. Calafat ◽  
Xiaoyum Ye ◽  
Daniel R. Doerge ◽  
Mona I. Churchwell ◽  
...  
Keyword(s):  
Bisphenol A ◽  
Human Urine ◽  
Dietary Exposure ◽  
Human Urine And Serum ◽  
Urine And Serum

scholarly journals PATTERNS OF WEALTH TRAJECTORY IN LATER LIFE: CRITICAL PERIOD, ACCUMULATION, AND SOCIAL MOBILITY MODELS

2019 ◽  
Vol 3 (Supplement_1) ◽  
pp. S382-S382
Author(s):  
Yu-Chih Chen ◽  
Sojung Park ◽  
Nancy Morrow-Howell
Keyword(s):  
Life Course ◽  
Social Mobility ◽  
Critical Period ◽  
Reference Group ◽  
Multinomial Logistic Regression ◽  
Later Life ◽  
Well Being ◽  
Economic Stress ◽  
Mobility Models ◽  
The Life Course

Abstract Wealth, an important financial cushion for older adults to buffer economic stress, requires a longer time to accumulate and develop in one’s course of life. However, little is known about the trajectories of wealth in later life, and how the life course socioeconomic status (SES) may contribute to the development of wealth at old-age. This study investigated longitudinal patterns of wealth trajectory and whether SES across the life course affects these trajectories using critical period, accumulation, and social mobility models. Using data from 16,189 adults aged 51 and older from the 2004-2014 Health and Retirement Study, a growth mixture model was used to explore distinct wealth trajectories. Impacts of life course models were studied using multinomial logistic regression. Results showed that four heterogeneous latent classes of wealth were identified: Stable high (reference group), Low and increasing, Stable low, and High but decline. Disadvantaged adulthood SES, accumulated exposure to socioeconomic risks, and downward or persistent socioeconomic disadvantage over the life course were associated with Stable low, Low and increasing, and High but decline, supporting all three life course mechanisms on wealth development in later life. Evidence suggests that wealth development is heterogeneous across individuals, and a strong gradient effect of life-course SES on wealth trajectories are clearly observed. Programs and policies should address the effects of life course on wealth development to strengthen the economic well-being in later life.

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