Effects of an acute exposure to toluene on the DNA repair activity of the human 8-oxoguanine DNA glycosylase 1 (hOGG1) in healthy subjects

2009 ◽  
Vol 83 (8) ◽  
pp. 777-784
Author(s):  
P. Finkenwirth ◽  
U. Spelmeyer ◽  
G. Hommel ◽  
D.-M. Rose ◽  
D. Jung ◽  
...  
Keyword(s):  
Dna Repair ◽  
Healthy Subjects ◽  
Acute Exposure ◽  
Dna Glycosylase ◽  
Repair Activity

Elevated N3-methylpurine-DNA glycosylase DNA repair activity is associated with lung cancer

2012 ◽  
Vol 732 (1-2) ◽  
pp. 43-46 ◽  
Author(s):  
Philip A.J. Crosbie ◽  
Amanda J. Watson ◽  
Raymond Agius ◽  
Philip V. Barber ◽  
Geoffrey P. Margison ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Dna Repair ◽  
Dna Glycosylase ◽  
Repair Activity ◽  
Methylpurine Dna Glycosylase

DNA repair activity of 8-oxoguanine DNA glycosylase 1 (OGG1) in human lymphocytes is not dependent on genetic polymorphism Ser326/Cys326

2001 ◽  
Vol 486 (3) ◽  
pp. 207-216 ◽  
Author(s):  
Kai Janssen ◽  
Kirsten Schlink ◽  
Walter Götte ◽  
Birgit Hippler ◽  
Bernd Kaina ◽  
...  
Keyword(s):  
Dna Repair ◽  
Genetic Polymorphism ◽  
Human Lymphocytes ◽  
Dna Glycosylase ◽  
Repair Activity

scholarly journals Germ Line Variants of HumanN-Methylpurine DNA Glycosylase Show Impaired DNA Repair Activity and Facilitate 1,N6-Ethenoadenine-induced Mutations

2014 ◽  
Vol 290 (8) ◽  
pp. 4966-4980 ◽  
Author(s):  
Sanjay Adhikari ◽  
Mahandranauth A. Chetram ◽  
Jordan Woodrick ◽  
Partha S. Mitra ◽  
Praveen V. Manthena ◽  
...  
Keyword(s):  
Dna Repair ◽  
Germ Line ◽  
Dna Glycosylase ◽  
Induced Mutations ◽  
Repair Activity ◽  
Methylpurine Dna Glycosylase

scholarly journals DASH-type cryptochromes – solved and open questions

2020 ◽  
Vol 401 (12) ◽  
pp. 1487-1493
Author(s):  
Stephan Kiontke ◽  
Tanja Göbel ◽  
Annika Brych ◽  
Alfred Batschauer
Keyword(s):  
Dna Repair ◽  
Circadian Clock ◽  
Blue Light ◽  
Dna Repair Enzymes ◽  
Repair Enzymes ◽  
Open Questions ◽  
Essential Components ◽  
Repair Activity ◽  
Almost All ◽  
Uv Lesions

AbstractDrosophila, Arabidopsis, Synechocystis, human (DASH)-type cryptochromes (cry-DASHs) form one subclade of the cryptochrome/photolyase family (CPF). CPF members are flavoproteins that act as DNA-repair enzymes (DNA-photolyases), or as ultraviolet(UV)-A/blue light photoreceptors (cryptochromes). In mammals, cryptochromes are essential components of the circadian clock feed-back loop. Cry-DASHs are present in almost all major taxa and were initially considered as photoreceptors. Later studies demonstrated DNA-repair activity that was, however, restricted to UV-lesions in single-stranded DNA. Very recent studies, particularly on microbial organisms, substantiated photoreceptor functions of cry-DASHs suggesting that they could be transitions between photolyases and cryptochromes.

scholarly journals P-glycoprotein attenuates DNA repair activity in multidrug-resistant cells by acting through the Cbp-Csk-Src cascade

Oncotarget ◽  
2017 ◽  
Vol 8 (28) ◽  
pp. 45072-45087 ◽  
Author(s):  
Li-Fang Lin ◽  
Ming-Hsi Wu ◽  
Vijaya Kumar Pidugu ◽  
I-Ching Ho ◽  
Tsann-Long Su ◽  
...  
Keyword(s):  
Dna Repair ◽  
Multidrug Resistant ◽  
P Glycoprotein ◽  
Repair Activity ◽  
Resistant Cells

scholarly journals The Mechanism of Dna Repair by Uracil-Dna Glycosylase: Studies Using Nucleotide Analogues

2000 ◽  
Vol 19 (10-12) ◽  
pp. 1505-1516 ◽  
Author(s):  
Angelika Rösler ◽  
George Panayotou ◽  
David P. Hornby ◽  
Tom Barlow ◽  
Tom Brown ◽  
...  
Keyword(s):  
Dna Repair ◽  
Dna Glycosylase ◽  
Uracil Dna Glycosylase ◽  
Nucleotide Analogues

A mammalian cell line deficient in activity of the DNA repair enzyme 5-hydroxymethyluracil-DNA glycosylase is resistant to the toxic effects of the thymidine analog 5-hydroxymethyl-2'-deoxyuridine

1992 ◽  
Vol 12 (12) ◽  
pp. 5536-5540
Author(s):  
R J Boorstein ◽  
L N Chiu ◽  
G W Teebor
Keyword(s):  
Dna Repair ◽  
Cell Line ◽  
Mammalian Cell ◽  
Dna Glycosylase ◽  
Mammalian Cell Line ◽  
Repair Enzyme ◽  
Thymidine Analog ◽  
Large Numbers ◽  
Mechanism Of Toxicity ◽  
Base Excision

We isolated a mutant mammalian cell line lacking activity for the DNA repair enzyme 5-hydroxymethyluracil-DNA glycosylase (HmUra-DNA glycosylase). The mutant was isolated through its resistance to the thymidine analog 5-hydroxymethyl-2'-deoxyuridine (HmdUrd). The mutant incorporates HmdUrd into DNA to the same extent as the parent line but, lacking the repair enzyme, does not remove it. The phenotype of the mutant demonstrates that the toxicity of HmdUrd does not result from substitution of thymine in DNA by HmUra but rather from the removal via base excision of large numbers of HmUra residues in DNA. This finding elucidates a novel mechanism of toxicity for a xenobiotic nucleoside. Furthermore, the isolation of this line supports our hypothesis that the enzymatic repairability of HmUra derives not from its formation opposite adenine via the oxidation of thymine, but rather from its formation opposite guanine as a product of the oxidation and subsequent deamination of 5-methylcytosine.

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