THA disrupts mismatch negativity in Alzheimer disease

1997 ◽  
Vol 133 (2) ◽  
pp. 203-206 ◽  
Author(s):  
P. Riekkinen Jr. ◽  
A. Pääkkönen ◽  
Jari Karhu ◽  
Juhani Partanen ◽  
Hilkka Soininen ◽  
...  
Keyword(s):  
Alzheimer Disease ◽  
Mismatch Negativity

Mismatch negativity as a potential neurobiological marker of early-stage Alzheimer disease and vascular dementia

2017 ◽  
Vol 647 ◽  
pp. 26-31 ◽  
Author(s):  
Shixiang Jiang ◽  
Chang Yan ◽  
Zhengxue Qiao ◽  
Haiqian Yao ◽  
Shiquan Jiang ◽  
...  
Keyword(s):  
Alzheimer Disease ◽  
Vascular Dementia ◽  
Mismatch Negativity ◽  
Early Stage

T52. Mismatch negativity in the diagnosis of Alzheimer disease

2018 ◽  
Vol 129 ◽  
pp. e21-e22
Author(s):  
Jui-Cheng Chen ◽  
Antonella Macerollo ◽  
Mark Edwards
Keyword(s):  
Alzheimer Disease ◽  
Mismatch Negativity

Structural and Chemical Studies of Pathological Fibers in Human Neurofibrillary Degeneration

1985 ◽  
Vol 43 ◽  
pp. 726-729
Author(s):  
K.S. Kosik ◽  
L.K. Duffy ◽  
S. Bakalis ◽  
C. Abraham ◽  
D.J. Selkoe
Keyword(s):  
Monoclonal Antibodies ◽  
Alzheimer Disease ◽  
Human Brain ◽  
Neurofibrillary Tangles ◽  
Morphological Analysis ◽  
High Specificity ◽  
Cytoskeletal Proteins ◽  
Neuritic Plaque ◽  
Protein Chemistry ◽  
Chemical Studies

The major structural lesions of the human brain during aging and in Alzheimer disease (AD) are the neurofibrillary tangles (NFT) and the senile (neuritic) plaque. Although these fibrous alterations have been recognized by light microscopists for almost a century, detailed biochemical and morphological analysis of the lesions has been undertaken only recently. Because the intraneuronal deposits in the NFT and the plaque neurites and the extraneuronal amyloid cores of the plaques have a filamentous ultrastructure, the neuronal cytoskeleton has played a prominent role in most pathogenetic hypotheses.The approach of our laboratory toward elucidating the origin of plaques and tangles in AD has been two-fold: the use of analytical protein chemistry to purify and then characterize the pathological fibers comprising the tangles and plaques, and the use of certain monoclonal antibodies to neuronal cytoskeletal proteins that, despite high specificity, cross-react with NFT and thus implicate epitopes of these proteins as constituents of the tangles.

Musical Experience Shapes Neural Processing

2020 ◽  
Vol 31 (2) ◽  
pp. 81-86
Author(s):  
Wido Nager ◽  
Tilla Franke ◽  
Tobias Wagner-Altendorf ◽  
Eckart Altenmüller ◽  
Thomas F. Münte
Keyword(s):  
Mismatch Negativity ◽  
Pure Tone ◽  
Musical Instrument ◽  
Active Listening ◽  
Musical Experience ◽  
Neural Processing ◽  
Neural Adaptations

Abstract. Playing a musical instrument professionally has been shown to lead to structural and functional neural adaptations, making musicians valuable subjects for neuroplasticity research. Here, we follow the hypothesis that specific musical demands further shape neural processing. To test this assumption, we subjected groups of professional drummers, professional woodwind players, and nonmusicians to pure tone sequences and drum sequences in which infrequent anticipations of tones or drum beats had been inserted. Passively listening to these sequences elicited a mismatch negativity to the temporally deviant stimuli which was greater in the musicians for tone series and particularly large for drummers for drum sequences. In active listening conditions drummers more accurately and more quickly detected temporally deviant stimuli.

Effects of Experimentally Induced Pain on Mismatch Negativity

2006 ◽  
Vol 20 (1) ◽  
pp. 21-31 ◽  
Author(s):  
Bruce D. Dick ◽  
John F. Connolly ◽  
Michael E. Houlihan ◽  
Patrick J. McGrath ◽  
G. Allen Finley ◽  
...  
Keyword(s):  
Cognitive Processing ◽  
Mismatch Negativity ◽  
Event Related Potentials ◽  
Disruptive Effect ◽  
Ischemic Pain ◽  
Active Attention ◽  
Early Processing ◽  
Related Potentials ◽  
Healthy Participants ◽  
Experimentally Induced

Abstract: Previous research has found that pain can exert a disruptive effect on cognitive processing. This experiment was conducted to extend previous research with participants with chronic pain. This report examines pain's effects on early processing of auditory stimulus differences using the Mismatch Negativity (MMN) in healthy participants while they experienced experimentally induced pain. Event-related potentials (ERPs) were recorded using target and standard tones whose pitch differences were easy- or difficult-to-detect in conditions where participants attended to (active attention) or ignored (passive attention) the stimuli. Both attention manipulations were conducted in no pain and pain conditions. Experimentally induced ischemic pain did not disrupt the MMN. However, MMN amplitudes were larger to difficult-to-detect deviant tones during painful stimulation when they were attended than when they were ignored. Also, MMN amplitudes were larger to the difficult- than to the easy-to-detect tones in the active attention condition regardless of pain condition. It appears that rather than exerting a disruptive effect, the presence of experimentally induced pain enhanced early processing of small stimulus differences in these healthy participants.

Human Event-Related Potentials to Higher-Order Acoustic Spatial Changes

2002 ◽  
Vol 16 (2) ◽  
pp. 114-118 ◽  
Author(s):  
Timo Ruusuvirta ◽  
Heikki Hämäläinen
Keyword(s):  
Working Memory ◽  
Mismatch Negativity ◽  
Spatial Information ◽  
Free Field ◽  
Event Related Potentials ◽  
Negative Polarity ◽  
Positive Polarity ◽  
Spatial Changes ◽  
Related Potentials ◽  
Human Event

Abstract Human event-related potentials (ERPs) to a tone continuously alternating between its two spatial loci of origin (middle-standards, left-standards), to repetitions of left-standards (oddball-deviants), and to the tones originally representing these repetitions presented alone (alone-deviants) were recorded in free-field conditions. During the recordings (Fz, Cz, Pz, M1, and M2 referenced to nose), the subjects watched a silent movie. Oddball-deviants elicited a spatially diffuse two-peaked deflection of positive polarity. It differed from a deflection elicited by left-standards and commenced earlier than a prominent deflection of negative polarity (N1) elicited by alone-deviants. The results are discussed in the context of the mismatch negativity (MMN) and previous findings of dissociation between spatial and non-spatial information in auditory working memory.

The Involuntary Capture of Attention by Sound

2010 ◽  
Vol 57 (1) ◽  
pp. 68-76 ◽  
Author(s):  
Fabrice B. R. Parmentier ◽  
Pilar Andrés
Keyword(s):  
Older Adults ◽  
Mismatch Negativity ◽  
Visual Task ◽  
The Novel ◽  
Auditory Oddball ◽  
Current Trial ◽  
Electrophysiological Responses ◽  
Electrophysiological Studies ◽  
The Cross ◽  
Task Sets

The presentation of auditory oddball stimuli (novels) among otherwise repeated sounds (standards) triggers a well-identified chain of electrophysiological responses: The detection of acoustic change (mismatch negativity), the involuntary orientation of attention to (P3a) and its reorientation from the novel. Behaviorally, novels reduce performance in an unrelated visual task (novelty distraction). Past studies of the cross-modal capture of attention by acoustic novelty have typically discarded from their analysis the data from the standard trials immediately following a novel, despite some evidence in mono-modal oddball tasks of distraction extending beyond the presentation of deviants/novels (postnovelty distraction). The present study measured novelty and postnovelty distraction and examined the hypothesis that both types of distraction may be underpinned by common frontally-related processes by comparing young and older adults. Our data establish that novels delayed responses not only on the current trial and but also on the subsequent standard trial. Both of these effects increased with age. We argue that both types of distraction relate to the reconfiguration of task-sets and discuss this contention in relation to recent electrophysiological studies.

Superior pitch perception in autism? Evidence of auditory mismatch negativity from Chinese

2013 ◽  
Author(s):  
Suiping Wang ◽  
Luodi Yu ◽  
Yuebo Fan ◽  
Zhizhou Deng ◽  
Dan Huang ◽  
...  
Keyword(s):  
Mismatch Negativity ◽  
Pitch Perception
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