Recent advances in synthetic biology–enabled and natural whole-cell optical biosensing of heavy metals

2020 ◽  
Author(s):  
Ankur Singh ◽  
Vipin Kumar
Keyword(s):  
Heavy Metals ◽  
Synthetic Biology ◽  
Optical Biosensing ◽  
Whole Cell ◽  
Recent Advances

scholarly journals Applications, challenges, and needs for employing synthetic biology beyond the lab

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Sierra M. Brooks ◽  
Hal S. Alper
Keyword(s):  
Synthetic Biology ◽  
Great Promise ◽  
Long Term Storage ◽  
Autonomous Function ◽  
Recent Advances ◽  
Resource Limited ◽  
Major Application ◽  
Further Development ◽  
Probiotic Delivery

AbstractSynthetic biology holds great promise for addressing global needs. However, most current developments are not immediately translatable to ‘outside-the-lab’ scenarios that differ from controlled laboratory settings. Challenges include enabling long-term storage stability as well as operating in resource-limited and off-the-grid scenarios using autonomous function. Here we analyze recent advances in developing synthetic biological platforms for outside-the-lab scenarios with a focus on three major application spaces: bioproduction, biosensing, and closed-loop therapeutic and probiotic delivery. Across the Perspective, we highlight recent advances, areas for further development, possibilities for future applications, and the needs for innovation at the interface of other disciplines.

Recent advances in the application of noble metal nanoparticles in colorimetric sensors for lead ions

2021 ◽  
Author(s):  
H Singh ◽  
Amy Bamrah ◽  
Sanjeev Kumar ◽  
A Deep ◽  
M Khatri ◽  
...  
Keyword(s):  
Heavy Metals ◽  
Metal Nanoparticles ◽  
Noble Metal ◽  
Chemical Properties ◽  
Lead Ions ◽  
Noble Metal Nanoparticles ◽  
Physical Chemical ◽  
Recent Advances ◽  
Recent Developments ◽  
Colorimetric Sensors

Recent developments in nanotechnology and engineering have produced a plethora of nanomaterials with amazing physical/chemical properties and enhanced sensing potential for various heavy metals in the environment. Noble metal nanoparticles...

scholarly journals Recent advances in natural products exploitation in Streptomyces via synthetic biology

2019 ◽  
Vol 19 (6) ◽  
pp. 452-462 ◽  
Author(s):  
Qiyuan Zhao ◽  
Liping Wang ◽  
Yunzi Luo
Keyword(s):  
Natural Products ◽  
Synthetic Biology ◽  
Recent Advances

scholarly journals Collaborating constructively for sustainable biotechnology

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Nicholas E. Matthews ◽  
Carrie A. Cizauskas ◽  
Donovan S. Layton ◽  
Laurence Stamford ◽  
Philip Shapira
Keyword(s):  
Life Cycle ◽  
Synthetic Biology ◽  
Social Impact ◽  
New Technologies ◽  
Sustainability Assessment ◽  
Early Stage ◽  
Impact Categories ◽  
Recent Advances ◽  
Trade Offs ◽  
Analytical Approaches

AbstractTackling the pressing sustainability needs of society will require the development and application of new technologies. Biotechnology, emboldened by recent advances in synthetic biology, offers to generate sustainable biologically-based routes to chemicals and materials as alternatives to fossil-derived incumbents. Yet, the sustainability potential of biotechnology is not without trade-offs. Here, we probe this capacity for sustainability for the case of bio-based nylon using both deliberative and analytical approaches within a framework of Constructive Sustainability Assessment. We highlight the potential for life cycle CO2 and N2O savings with bio-based processes, but report mixed results in other environmental and social impact categories. Importantly, we demonstrate how this knowledge can be generated collaboratively and constructively within companies at an early stage to anticipate consequences and to inform the modification of designs and applications. Application of the approach demonstrated here provides an avenue for technological actors to better understand and become responsive to the sustainability implications of their products, systems and actions.

Deciphering the regulation of metabolism with dynamic optimization: an overview of recent advances

2017 ◽  
Vol 45 (4) ◽  
pp. 1035-1043 ◽  
Author(s):  
Jan Ewald ◽  
Martin Bartl ◽  
Christoph Kaleta
Keyword(s):  
Dynamic Optimization ◽  
Metabolic Pathways ◽  
Regulatory Networks ◽  
Optimization Problems ◽  
Treatment Strategies ◽  
Whole Cell ◽  
Recent Advances ◽  
Regulatory Strategies ◽  
Regulation Of Metabolism ◽  
Optimality Principles

Understanding optimality principles shaping the evolution of regulatory networks controlling metabolism is crucial for deriving a holistic picture of how metabolism is integrated into key cellular processes such as growth, adaptation and pathogenicity. While in the past the focus of research in pathway regulation was mainly based on stationary states, more recently dynamic optimization has proved to be an ideal tool to decipher regulatory strategies for metabolic pathways in response to environmental cues. In this short review, we summarize recent advances in the elucidation of optimal regulatory strategies and identification of optimal control points in metabolic pathways. We discuss biological implications of the discovered optimality principles on genome organization and provide examples how the derived knowledge can be used to identify new treatment strategies against pathogens. Furthermore, we briefly discuss the variety of approaches for solving dynamic optimization problems and emphasize whole-cell resource allocation models as an important emerging area of research that will allow us to study the regulation of metabolism on the whole-cell level.

Whole cell- and protein-based biosensors for the detection of bioavailable heavy metals in environmental samples

1999 ◽  
Vol 387 (3) ◽  
pp. 235-244 ◽  
Author(s):  
Philippe Corbisier ◽  
Daniel van der Lelie ◽  
Brigitte Borremans ◽  
Ann Provoost ◽  
Victor de Lorenzo ◽  
...  
Keyword(s):  
Heavy Metals ◽  
Environmental Samples ◽  
Whole Cell

Recent advances in synthetic biology of cyanobacteria

2018 ◽  
Vol 102 (13) ◽  
pp. 5457-5471 ◽  
Author(s):  
Annesha Sengupta ◽  
Himadri B. Pakrasi ◽  
Pramod P. Wangikar
Keyword(s):  
Synthetic Biology ◽  
Recent Advances

scholarly journals Advances in heavy metal removal by sulfate-reducing bacteria

2020 ◽  
Vol 81 (9) ◽  
pp. 1797-1827 ◽  
Author(s):  
Ya-Nan Xu ◽  
Yinguang Chen
Keyword(s):  
Heavy Metals ◽  
Heavy Metal ◽  
Industrial Development ◽  
Metal Removal ◽  
Heavy Metal Removal ◽  
Sulfate Reducing Bacteria ◽  
Sulfate Reducing ◽  
Recent Advances ◽  
Conventional Methods ◽  
Reducing Bacteria

Abstract Industrial development has led to generation of large volumes of wastewater containing heavy metals, which need to be removed before the wastewater is released into the environment. Chemical and electrochemical methods are traditionally applied to treat this type of wastewater. These conventional methods have several shortcomings, such as secondary pollution and cost. Bioprocesses are gradually gaining popularity because of their high selectivities, low costs, and reduced environmental pollution. Removal of heavy metals by sulfate-reducing bacteria (SRB) is an economical and effective alternative to conventional methods. The limitations of and advances in SRB activity have not been comprehensively reviewed. In this paper, recent advances from laboratory studies in heavy metal removal by SRB were reported. Firstly, the mechanism of heavy metal removal by SRB is introduced. Then, the factors affecting microbial activity and metal removal efficiency are elucidated and discussed in detail. In addition, recent advances in selection of an electron donor, enhancement of SRB activity, and improvement of SRB tolerance to heavy metals are reviewed. Furthermore, key points for future studies of the SRB process are proposed.

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