Application of Photoacoustic Imaging for Lymphedema Treatment

Background Lymphatic vessels are difficult to identify using existing modalities as because of their small diameter and the transparency of the lymph fluid flowing through them. Methods Here, we introduce photoacoustic lymphangiography (PAL), a new modality widely used for lymphedema treatment, to observe limb lymphatic vessels. The photoacoustic imaging system used in this study can simultaneously visualize lymphatic vessels and veins with a high resolution (0.2 mm) and can also observe their three-dimensional relationship with each other. Results High-resolution images of the lymphatic vessels, detailed structure of the dermal back flow, and the three-dimensional positional relationship between the lymphatic vessels and veins were observed by PAL. Conclusion The clear image provided by PAL could have a major application in pre- and postoperative use during lymphaticovenular anastomosis for lymphedema treatment.

A comprehensive review of the pyrolysis process: from carbon nanomaterial synthesis to waste treatment

Thermally induced chemical decomposition of organic materials in the absence of oxygen is defined as pyrolysis. This process has four major application areas: (i) production of carbon materials, (ii) fabrication of pre-patterned micro and nano carbon-based structures, (iii) fragmentation of complex organic molecules for analytical purposes and (iv) waste treatment. While the underlying process principles remain the same in all cases, the target products differ owing to the phase and composition of the organic precursor, heat-treatment temperature, influence of catalysts and the presence of post-pyrolysis steps during heat-treatment. Due to its fundamental nature, pyrolysis is often studied in the context of one particular application rather than as an independent operation. In this review article an effort is made to understand each aspect of pyrolysis in a comprehensive fashion, ensuring that all state-of-the-art applications are approached from the core process parameters that influence the ensuing product. Representative publications from recent years for each application are reviewed and analyzed. Some classical scientific findings that laid the foundation of the modern-day carbon material production methods are also revisited. In addition, classification of pyrolysis, its history and nomenclature and the plausible integration of different application areas are discussed.

IDBR: Iot Enabled Depth Base Routing Method for Underwater Wireless Sensor Network

Underwater wireless sensor networks (UWSNs) gained the attention of researchers due to their substantial applications in various fields. The major application areas of UWSN are environmental monitoring, underwater oil and gas extraction and military surveillance, smart farming, communication, and others. However, UWSNs are also prone to significant issues, such as limited network lifetime, the low processing capability of nodes, high energy consumption to run routing protocols, and difficult node replacement. Therefore, enhancing the lifetime of UWSN by reducing energy consumption and processing is a research issue. In this research, we proposed the IoT enabled depth base routing method (IDBR) to utilize energy efficiently. The performance of the proposed IDBR method is compared with conventional DBR protocol using simulation conducting in MATLAB. The performance of both the methods (i.e., IDBR and DBR) is evaluated in network energy consumption, the number of alive nodes, sink utilization, and end-to-end delay. The simulation-based experiment results show that IDBR consumes 27.7% less energy and increases network stability than the DBR. Similarly, the utilization of the surface sinks in IDBR is more as compared to DBR as in IDBR, and sinks work as relay forward data to the base station without processing which increases the power of field nodes. The proposed mechanism improves the network’s lifetime and increases the accessibility and security of the sensed data.

Analysis of solar cooker with thermal storage for remote hilly areas: determination of heating and cooling characteristic time

Solar cooking finds a major application in rural areas of Uttarakhand, India, yet its utilization is still limited due to certain limitation such as intermittent nature of solar radiations. This drawback limits solar cooker in becoming a viable alternate solution of LPG and other pollution causing resources such as wood. In order to cater this problem a numerical analysis of box type solar cooker with storage is carried out. The energy stored in the storage material will keep the cooker warm up to the time when food is consumed. Charging and discharging time analysis is performed in with an aim to understand the effect of storage on solar cooker. Heating and cooling characteristic time are being evaluated and analysed with storage. Thermal performance of box type solar cooker is measured in terms of figures of merit according to BIS standards. The effect of storage has also been analysed in terms of charging and discharging time and first figure of merit of box type solar cooker.it has been observed that during discharging the heat is stored for more duration as compared to the charging time as discharge time is approx. 4-5 hours while charging time for the same amount of insolation is around 3-4 hours.

Exosomes in Dogs and Cats: An Innovative Approach to Neoplastic and Non-Neoplastic Diseases

Exosomes are extracellular vesicles with a diameter between 40 and 120 nm, which are derived from all types of cells and released into all biological fluids, such as blood plasma, serum, urine, breast milk, colostrum, and more. They contain proteins, nucleic acids (mRNA, miRNA, other non-coding RNA, and DNA), and lipids. Exosomes represent a potentially accurate footprint of the miRNA profile of the parental cell and can therefore be proposed as potential and sensitive biomarkers, both in diagnosing and monitoring a variety of diseases in humans and animals. Liquid biopsy offers itself as a non-invasive or minimally invasive, pain-free, time-saving alternative to conventional tissue biopsy. Exosomes in both human and veterinary medicine find their major application in neoplastic diseases, but applications in the field of veterinary cardiology, nephrology, reproduction, parasitology, and regenerative medicine are currently being explored. Exosomes can therefore be used as diagnostic, prognostic, and, in some cases, therapeutic tools for several conditions. The aim of this review was to assess the current applications of exosomes in veterinary medicine, particularly in dog and cat patients.

Neurocosmetics in Skincare—The Fascinating World of Skin–Brain Connection: A Review to Explore Ingredients, Commercial Products for Skin Aging, and Cosmetic Regulation

The “modern” cosmetology industry is focusing on research devoted to discovering novel neurocosmetic functional ingredients that could improve the interactions between the skin and the nervous system. Many cosmetic companies have started to formulate neurocosmetic products that exhibit their activity on the cutaneous nervous system by affecting the skin’s neuromediators through different mechanisms of action. This review aims to clarify the definition of neurocosmetics, and to describe the features of some functional ingredients and products available on the market, with a look at the regulatory aspect. The attention is devoted to neurocosmetic ingredients for combating skin stress, explaining the stress pathways, which are also correlated with skin aging. “Neuro-relaxing” anti-aging ingredients derived from plant extracts and neurocosmetic strategies to combat inflammatory responses related to skin stress are presented. Afterwards, the molecular basis of sensitive skin and the suitable neurocosmetic ingredients to improve this problem are discussed. With the aim of presenting the major application of Botox-like ingredients as the first neurocosmetics on the market, skin aging is also introduced, and its theory is presented. To confirm the efficacy of the cosmetic products on the market, the concept of cosmetic claims is discussed.

APPLICATION OF MULTIPLE CRITERIA DECISION MAKING METHODS IN CONSTRUCTION: A SYSTEMATIC LITERATURE REVIEW

Decision making is a key to business or project success in any sectors, especially in construction that requires handling numerous information and knowledge. Multiple criteria decision making (MCDM) is an important tool for decision problem solving due to simultaneous consideration of multiple criteria and objectives. Various MCDM methods are continually emerging and tend to be increasingly adopted to address the real-world construction problems. Therefore, it is urged to systematically review the existing body of literature to demonstrate the evolution of the mainstream MCDM methods in general and their application status in construction. A total of 530 construction articles published from 2000 to 2019 are selected in this study and then categorized into seven major application areas using a novel systematic literature review (SLR) methodology. The bibliometric analysis is then used to describe the research trend. Subsequently, the qualitative discussion by themes is conducted to analyze the application of MCDM methods in construction. A further discussion makes it possible to identify the potential challenges (e.g. applicability, robustness, postpone effect, dynamic and prospective challenges and scale problem) to existing research. It also contributes to the recommendation of future directions for the development of MCDM methods that would benefit construction research and practice.

ChCl: Gly (DESs) Promote Environmentally Benign Synthesis of Xanthene Derivatives and Their Antitubercular Activity

A ChCl: Gly (DESs) promoted environmentally benign method was developed for the first time using the reaction of aryl aldehydes and dimedone to give excellent yields of xanthene analogues. The major application of this present protocol is the use of green solvent, a wide range of substrate, short reaction times, ease of recovery, the recyclability of the catalyst, high reaction yield, and ChCl: Gly as an alternative catalyst and solvent. In addition to this, all the synthesized compounds were evaluated for their in vitro antimycobacterial activity against M. tuberculosis H37Ra (MTB) and M. bovis BCG strains. The compounds 3d, 3e, 3f, and 3j showed significant antitubercular activity against MTB and M. bovis strains with minimum inhibitory concentration (MIC) values of 2.5−15.10 µg/mL and 0.26–14.92 µg/mL, respectively. The compounds 3e, 3f, and 3j were found to be nontoxic against MCF-7, A549, HCT 116, and THP-1 cell lines. All the prepared compounds were confirmed by 1H NMR and 13C NMR analysis.

Machine learning in dental, oral and craniofacial imaging: a review of recent progress

Artificial intelligence has been emerging as an increasingly important aspect of our daily lives and is widely applied in medical science. One major application of artificial intelligence in medical science is medical imaging. As a major component of artificial intelligence, many machine learning models are applied in medical diagnosis and treatment with the advancement of technology and medical imaging facilities. The popularity of convolutional neural network in dental, oral and craniofacial imaging is heightening, as it has been continually applied to a broader spectrum of scientific studies. Our manuscript reviews the fundamental principles and rationales behind machine learning, and summarizes its research progress and its recent applications specifically in dental, oral and craniofacial imaging. It also reviews the problems that remain to be resolved and evaluates the prospect of the future development of this field of scientific study.