The effect of long-term microcrystalline chitosan therapy on plasma lipids and glucose concentrations in subjects with increased plasma total cholesterol: a randomised placebo-controlled double-blind crossover trial in healthy men and women

1. A randomized double-blind crossover trial was carried out to compare the influence on plasma lipid concentrations, platelet thromboxane B2production and platelet aggregation induced by ADP, collagen and U46619 (a prostaglandin endoperoxide analogue), of a daily 10 g supplement of a fish-oil concentrate (MaxEPA), which provided (g): 1·7 20:5ω3, 0·3 22:5ω3 and 1·2 22:6ω3, taken for 2 weeks by ten healthy subjects, with one of vegetable oil providing 3·4 18:2ω6.2. A lower response to platelet aggregation induced by 0·5 μg collagen/ml but not by other aggregating agents was observed following both types of supplement. Platelet thromboxane B2production induced by collagen also tended to be lower following the supplements.3. Plasma total cholesterol concentrations were unaffected by the supplements. The MaxEPA but not the vegetable-oil supplement lowered the concentration of plasma triglycerides and increased that of high-density-lipoprotein-cholesterol.

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Long-term Effect of Sotalol on Plasma Lipids

Clinical Science ◽

10.1042/cs057405s ◽

1979 ◽

Vol 57 (s5) ◽

pp. 405s-407s ◽

Cited By ~ 52

Author(s):

A. Lehtonen ◽

J. Viikari

Keyword(s):

Total Cholesterol ◽

Plasma Lipids ◽

Plasma Cholesterol ◽

Hdl Cholesterol ◽

Plasma Free Fatty Acid ◽

Cholesterol Concentration ◽

Plasma Total Cholesterol ◽

Long Term Effect ◽

The Difference

1. We studied the effect on plasma lipids of sotalol given orally over a 12 month period to patients with essential hypertension. 2. Plasma free fatty acid concentration was lower than initially at 1, 3, 6 and 12 months. The difference was significant (P < 0·01) at 1 and 3 months. 3. Plasma cholesterol (VLDL + LDL-cholesterol) increased during treatment. Plasma total cholesterol increased from 5·49 ± sd 0·94 mmol/l at the beginning to 6·37 ± 1·10 mmol/l at 12 months (P < 0·01). 4. HDL-cholesterol concentration and the ratio of HDL-cholesterol to total cholesterol decreased significantly. The ratios were 0·28 and 0·18 at the beginning and at 12 months respectively (P < 0·001). 5. Plasma triglycerides increased simultaneously from 1·14 ± 0·31 to 1·89 ± 0·99 mmol/l (P < 0·01).

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Reduction of Serum Total Cholesterol and LDL-cholesterol by Chocolate Containing Plant Sterol in Subjects with Borderline-high Cholesterol or Mild Hypercholesterolemia ―Efficacy and Safety of Long-term Intake in a Randomized Double-blind, Placebo-controlled Trial―

Nippon Eiyo Shokuryo Gakkaishi ◽

10.4327/jsnfs.65.261 ◽

2012 ◽

Vol 65 (6) ◽

pp. 261-270

Author(s):

Masataka Hoshino ◽

Yukari Soejima ◽

Yuuichi Maeda ◽

Toshiyuki Ogata ◽

Susumu Shimura ◽

...

Keyword(s):

Total Cholesterol ◽

Plant Sterol ◽

Ldl Cholesterol ◽

Controlled Trial ◽

Serum Total Cholesterol ◽

Efficacy And Safety ◽

High Cholesterol ◽

Double Blind ◽

Double Blind Placebo

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Guanidinoacetic acid versus creatine for improved brain and muscle creatine levels: a superiority pilot trial in healthy men

Applied Physiology Nutrition and Metabolism ◽

10.1139/apnm-2016-0178 ◽

2016 ◽

Vol 41 (9) ◽

pp. 1005-1007 ◽

Cited By ~ 17

Author(s):

Sergej M. Ostojic ◽

Jelena Ostojic ◽

Patrik Drid ◽

Milan Vranes

Keyword(s):

Grey Matter ◽

Crossover Trial ◽

Pilot Trial ◽

Double Blind ◽

Middle Cerebellar Peduncle ◽

Healthy Men ◽

Acid Versus ◽

Guanidinoacetic Acid ◽

Vastus Medialis Muscle ◽

Cerebellar Peduncle

In this randomized, double-blind, crossover trial, we evaluated whether 4-week supplementation with guanidinoacetic acid (GAA) is superior to creatine in facilitating creatine levels in healthy men (n = 5). GAA (3.0 g/day) resulted in a more powerful rise (up to 16.2%) in tissue creatine levels in vastus medialis muscle, middle-cerebellar peduncle, and paracentral grey matter, as compared with creatine (P < 0.05). These results indicate that GAA as a preferred alternative to creatine for improved bioenergetics in energy-demanding tissues.

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