scholarly journals Differentiation of high-grade from low-grade diffuse gliomas using diffusion-weighted imaging: a comparative study of mono-, bi-, and stretched-exponential diffusion models

2020 ◽  
Vol 62 (7) ◽  
pp. 815-823
Author(s):  
Masaoki Kusunoki ◽  
Kazufumi Kikuchi ◽  
Osamu Togao ◽  
Koji Yamashita ◽  
Daichi Momosaka ◽  
...  
Keyword(s):  
Comparative Study ◽  
Diffusion Weighted Imaging ◽  
Diffusion Models ◽  
Low Grade ◽  
High Grade ◽  
Stretched Exponential ◽  
Diffusion Weighted ◽  
Diffuse Gliomas

The Added Value of Inflow-Based Vascular-Space-Occupancy and Diffusion-Weighted Imaging in Preoperative Grading of Gliomas

2021 ◽  
pp. 1-8
Author(s):  
Haimei Cao ◽  
Xiang Xiao ◽  
Jun Hua ◽  
Guanglong Huang ◽  
Wenle He ◽  
...  
Keyword(s):  
Diagnostic Accuracy ◽  
Roc Curve ◽  
Diffusion Weighted Imaging ◽  
Low Grade ◽  
High Grade ◽  
Mr Images ◽  
Vascular Space ◽  
Diffusion Weighted ◽  
High Grade Gliomas ◽  
And Diffusion

Objectives: The present study aimed to study whether combined inflow-based vascular-space-occupancy (iVASO) MR imaging (MRI) and diffusion-weighted imaging (DWI) improve the diagnostic accuracy in the preoperative grading of gliomas. Methods: Fifty-one patients with histopathologically confirmed diffuse gliomas underwent preoperative structural MRI, iVASO, and DWI. We performed 2 qualitative consensus reviews: (1) structural MR images alone and (2) structural MR images with iVASO and DWI. Relative arteriolar cerebral blood volume (rCBVa) and minimum apparent diffusion coefficient (mADC) were compared between low-grade and high-grade gliomas. Receiver operating characteristic (ROC) curve analysis was performed to compare the tumor grading efficiency of rCBVa, mADC, and the combination of the two parameters. Results: Two observers diagnosed accurate tumor grade in 40 of 51 (78.4%) patients in the first review and in 46 of 51 (90.2%) in the second review. Both rCBVa and mADC showed significant differences between low-grade and high-grade gliomas. ROC analysis gave a threshold value of 1.52 for rCBVa and 0.85 × 10−3 mm2/s for mADC to provide a sensitivity and specificity of 88.0 and 81.2% and 100.0 and 68.7%, respectively. The area under the ROC curve (AUC) was 0.87 and 0.85 for rCBVa and mADC, respectively. The combination of rCBVa and mADC values increased the AUC to 0.92. Conclusion: The combined application of iVASO and DWI may improve the diagnostic accuracy of glioma grading.

Diffusion Weighted Imaging of Brain Gliomas in the Differential Diagnosis Value

2020 ◽  
Author(s):  
Jian JIANG ◽  
Liangcai BAI ◽  
Xueling ZHANG ◽  
Jianli LIU ◽  
Junlin ZHOU
Keyword(s):  
Brain Metastases ◽  
Diffusion Weighted Imaging ◽  
High Grade Glioma ◽  
Low Grade Glioma ◽  
Control Group ◽  
Low Grade ◽  
High Grade ◽  
Imaging Data ◽  
Grade Group ◽  
Diffusion Weighted

Background: To evaluate the diagnostic value of diffusion weighted imaging (DWI) and apparent diffusion coefficient measurement (ADC) in glioma. cient measurement (ADC) in glioma. Methods: Thirty two low-grade glioma patients and 31 high-grade glioma patients who were confirmed by pathology in Lanzhou University Second Hospital, Lanzhou, China from February 2016 to January 2019 were selected. The other 30 patients with brain metastases were selected as a control group. DWI imaging data of the three groups were collected, and ADC, relative ADC (rADC) values in tumor parenchyma, peritumor edema area, and contralateral normal white matter area were measured, and the levels of n-acetyl aspartic acid (NAA), choline (Cho), creatine (Cr) of tumor metabolites were analyzed. Results: rADC values in the peri-tumor edema areas of the high-grade glioma group were significantly lower than those in the low-grade group and the metastatic group （P=0.011）, and the low-grade group was significantly lower than that in the metastatic group (P < 0.05). NAA/Cho and NAA/Cr in parenchymal and peritumor edema areas of patients in the advanced group were significantly lower than those in the metastatic group (P < 0.05), and Cho /Cr was significantly higher than those in the metastatic group (P < 0.05). Conclusion: the rADC value, NAA/Cho, NAA/Cr and Cho/Cr in parenchymal and peritumor edema areas of the tumor can help to distinguish high-grade glioma, low-grade glioma and brain metastases.

Usefulness of perfusion- and diffusion-weighted imaging to differentiate between pilocytic astrocytomas and high-grade gliomas: a multicenter study in Japan

2018 ◽  
Vol 60 (4) ◽  
pp. 391-401 ◽  
Author(s):  
Kazufumi Kikuchi ◽  
Akio Hiwatashi ◽  
Osamu Togao ◽  
Koji Yamashita ◽  
Ryotaro Kamei ◽  
...  
Keyword(s):  
Multicenter Study ◽  
Diffusion Weighted Imaging ◽  
High Grade ◽  
Diffusion Weighted ◽  
Pilocytic Astrocytomas ◽  
High Grade Gliomas ◽  
And Diffusion

scholarly journals Multiparametrical diffusion weighted imaging for the detection of anaplastic transformation of low-grade gliomas

2014 ◽  
Vol 14 (S1) ◽  
Author(s):  
MT Freitag ◽  
C Weber ◽  
K Maier-Hein ◽  
R Tarnawski ◽  
B Bobek-Billewicz ◽  
...  
Keyword(s):  
Diffusion Weighted Imaging ◽  
Low Grade ◽  
Low Grade Gliomas ◽  
Diffusion Weighted ◽  
Anaplastic Transformation

scholarly journals Comparison of Monoexponential, Biexponential, Stretched-Exponential, and Kurtosis Models of Diffusion-Weighted Imaging in Differentiation of Renal Solid Masses

2019 ◽  
Vol 20 (5) ◽  
pp. 791 ◽  
Author(s):  
Jianjian Zhang ◽  
Shiteng Suo ◽  
Guiqin Liu ◽  
Shan Zhang ◽  
Zizhou Zhao ◽  
...  
Keyword(s):  
Diffusion Weighted Imaging ◽  
Stretched Exponential ◽  
Diffusion Weighted

Cerebral schistosomiasis: diffusion-weighted imaging helps to differentiate from brain glioma and metastasis

2017 ◽  
Vol 58 (11) ◽  
pp. 1371-1377 ◽  
Author(s):  
Jinbai Huang ◽  
Jing Luo ◽  
Jie Peng ◽  
Tao Yang ◽  
Huanghua Zheng ◽  
...  
Keyword(s):  
Brain Metastasis ◽  
Diffusion Weighted Imaging ◽  
Brain Mri ◽  
High Grade ◽  
Post Contrast ◽  
Adc Value ◽  
Diffusion Weighted ◽  
Perifocal Edema ◽  
Adc Values ◽  
High Grade Gliomas

Background Diffusion-weighted imaging (DWI) was introduced into clinical use some years ago. However, its use in the diagnosis of cerebral schistosomiasis has not been reported. Purpose To investigate the ability of the apparent diffusion coefficient (ADC) value of DWI in the diagnosis of cerebral schistosomiasis, and to differentiate it from brain high-grade gliomas and metastasis. Material and Methods Conventional brain MRI with pre-contrast, post-contrast, and DWI was performed on 50 cases of cerebral schistosomiasis, high-grade glioma, and brain metastasis. The ADC values of the three lesions, the proximal and the distal perifocal edema were measured. In order to remove the individual difference effect of ADC values, relative ADC (rADC) values were calculated through dividing the ADC value of the lesion area by that of the contralateral normal white matter. rADC values were used to evaluate the differences among cerebral schistosomiasis, brain high-grade gliomas, and metastasis. Results rADC of cerebral schistosomiasis was significantly lower than rADC of brain metastasis ( P < 0.05), without any significant differences when compared with high-grade gliomas. rADC of proximal perifocal edema in cerebral schistosomiasis was significantly higher than in high-grade gliomas ( P < 0.010), but not different compared with brain metastasis. Conclusion DWI examination with ADC values of lesions and proximal perifocal edema might be helpful in the exact diagnosis of cerebral schistosomiasis.

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