Embryonic Exposure to Low Concentrations of Bisphenol A and S Altered Genes Related to Pancreatic β-Cell Development and DNA Methyltransferase in Zebrafish

2021 ◽  
Vol 80 (2) ◽  
pp. 450-460
Author(s):  
Eric Gyimah ◽  
Xing Dong ◽  
Hai Xu ◽  
Zhen Zhang ◽  
John Kenneth Mensah
Keyword(s):  
Bisphenol A ◽  
Dna Methyltransferase ◽  
Cell Development ◽  
Pancreatic Β Cell ◽  
Β Cell ◽  
Embryonic Exposure ◽  
Low Concentrations

scholarly journals Epigenetic disruption and glucose homeostasis changes following low-dose maternal bisphenol A exposure

2016 ◽  
Vol 5 (5) ◽  
pp. 1400-1409 ◽  
Author(s):  
Huailong Chang ◽  
Danqi Wang ◽  
Wei Xia ◽  
Xinyun Pan ◽  
Wenqian Huo ◽  
...  
Keyword(s):  
Bisphenol A ◽  
Glucose Homeostasis ◽  
Early Life ◽  
Low Dose ◽  
Cell Development ◽  
Pancreatic Function ◽  
Pancreatic Β Cell ◽  
Β Cell ◽  
Developmental Exposure ◽  
Epigenetic Disruption

Developmental exposure to bisphenol A (BPA) has been linked to impaired glucose homeostasis and pancreatic function in adulthood, which has been hypothesized to result from the disruption of pancreatic β-cell development at early life.

Pancreatic β-Cell Development and Regeneration

2021 ◽  
pp. a040741
Author(s):  
Natanya Kerper ◽  
Sudipta Ashe ◽  
Matthias Hebrok
Keyword(s):  
Cell Development ◽  
Pancreatic Β Cell ◽  
Β Cell

scholarly journals NKX6.1 transcription factor: a crucial regulator of pancreatic β cell development, identity, and proliferation

2020 ◽  
Vol 11 (1) ◽  
Author(s):  
Idil I. Aigha ◽  
Essam M. Abdelalim
Keyword(s):  
Transcription Factor ◽  
Cell Function ◽  
Disease Modeling ◽  
Critical Role ◽  
Cell Mass ◽  
Cell Development ◽  
Pancreatic Β Cell ◽  
Β Cells ◽  
Β Cell ◽  
Β Cell Function

Abstract Understanding the biology underlying the mechanisms and pathways regulating pancreatic β cell development is necessary to understand the pathology of diabetes mellitus (DM), which is characterized by the progressive reduction in insulin-producing β cell mass. Pluripotent stem cells (PSCs) can potentially offer an unlimited supply of functional β cells for cellular therapy and disease modeling of DM. Homeobox protein NKX6.1 is a transcription factor (TF) that plays a critical role in pancreatic β cell function and proliferation. In human pancreatic islet, NKX6.1 expression is exclusive to β cells and is undetectable in other islet cells. Several reports showed that activation of NKX6.1 in PSC-derived pancreatic progenitors (MPCs), expressing PDX1 (PDX1+/NKX6.1+), warrants their future commitment to monohormonal β cells. However, further differentiation of MPCs lacking NKX6.1 expression (PDX1+/NKX6.1−) results in an undesirable generation of non-functional polyhormonal β cells. The importance of NKX6.1 as a crucial regulator in MPC specification into functional β cells directs attentions to further investigating its mechanism and enhancing NKX6.1 expression as a means to increase β cell function and mass. Here, we shed light on the role of NKX6.1 during pancreatic β cell development and in directing the MPCs to functional monohormonal lineage. Furthermore, we address the transcriptional mechanisms and targets of NKX6.1 as well as its association with diabetes.

scholarly journals Association of variants in genes involved in pancreatic β-cell development and function with type 2 diabetes in North Indians

2011 ◽  
Vol 56 (10) ◽  
pp. 695-700 ◽  
Author(s):  
Sreenivas Chavali ◽  
Anubha Mahajan ◽  
Rubina Tabassum ◽  
Om Prakash Dwivedi ◽  
Ganesh Chauhan ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Cell Development ◽  
Pancreatic Β Cell ◽  
Β Cell ◽  
North Indians ◽  
And Function

scholarly journals The Estrogenic Effect of Bisphenol A Disrupts Pancreatic β-Cell Function In Vivo and Induces Insulin Resistance

2006 ◽  
Vol 114 (1) ◽  
pp. 106-112 ◽  
Author(s):  
Paloma Alonso-Magdalena ◽  
Sumiko Morimoto ◽  
Cristina Ripoll ◽  
Esther Fuentes ◽  
Angel Nadal
Keyword(s):  
Insulin Resistance ◽  
Bisphenol A ◽  
Cell Function ◽  
Pancreatic Β Cell ◽  
Β Cell ◽  
Estrogenic Effect ◽  
Β Cell Function

S1816 GDNF Influences Pancreatic β-Cell Development Through Increased Pancreatic Endocrine Progenitor Expression

2009 ◽  
Vol 136 (5) ◽  
pp. A-276
Author(s):  
Simon Mwangi ◽  
Bindu P. Chandrasekharan ◽  
Mallappa Anitha ◽  
Yousef Usta ◽  
Shanthi V. Sitaraman ◽  
...  
Keyword(s):  
Cell Development ◽  
Pancreatic Β Cell ◽  
Β Cell

scholarly journals Bisphenol A and 17α-ethinylestradiol-induced transgenerational gene expression differences in the brain–pituitary–testis axis of medaka, Oryzias latipes†

2020 ◽  
Vol 103 (6) ◽  
pp. 1324-1335
Author(s):  
Albert J Thayil ◽  
Xuegeng Wang ◽  
Pooja Bhandari ◽  
Frederick S vom Saal ◽  
Donald E Tillitt ◽  
...  
Keyword(s):  
Gene Expression ◽  
Bisphenol A ◽  
Dna Methyltransferase ◽  
Endocrine Disrupting Chemicals ◽  
Embryo Survival ◽  
Embryonic Exposure ◽  
Expression Of Genes ◽  
F2 Generation ◽  
The Brain ◽  
Generation Male

Abstract Endocrine disrupting chemicals (EDCs), such as bisphenol A (BPA) and 17α-ethinylestradiol (EE2), can have far reaching health effects, including transgenerational abnormalities in offspring that never directly contacted either chemical. We previously reported reduced fertilization rates and embryo survival at F2 and F3 generations caused by 7-day embryonic exposure (F0) to 100 μg/L BPA or 0.05 μg/L EE2 in medaka. Crossbreeding of fish in F2 generation indicated subfertility in males. To further understand the mechanisms underlying BPA or EE2-induced adult onset and transgenerational reproductive defects in males, the present study examined the expression of genes regulating the brain–pituitary–testis (BPT) axis in the same F0 and F2 generation male medaka. Embryonic exposure to BPA or EE2 led to hyperactivation of brain and pituitary genes, which are actively involved in reproduction in adulthood of the F0 generation male fish, and some of these F0 effects continued to the F2 generation (transgenerational effects). Particularly, the F2 generation inherited the hyperactivated state of expression for kisspeptin (kiss1 and kiss2) and their receptors (kiss1r and kiss2r), and gnrh and gnrh receptors. At F2 generation, expression of DNA methyltransferase 1 (dnmt1) decreased in brain of the BPA treatment lineage, while EE2 treatment lineage showed increased dnmt3bb expression. Global hypomethylation pattern was observed in the testis of both F0 and F2 generation fish. Taken together, these results demonstrated that BPA or EE2-induced transgenerational reproductive impairment in the F2 generation was associated with alterations of reproductive gene expression in brain and testis and global DNA methylation in testis.

scholarly journals Revealing transcription factors during human pancreatic β cell development

2014 ◽  
Vol 25 (8) ◽  
pp. 407-414 ◽  
Author(s):  
Elizabeth Conrad ◽  
Roland Stein ◽  
Chad S. Hunter
Keyword(s):  
Transcription Factors ◽  
Cell Development ◽  
Pancreatic Β Cell ◽  
Β Cell
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