scholarly journals Phenotyping Thermal Responses of Yeasts and Yeast-like Microorganisms at the Individual and Population Levels: Proof-of-Concept, Development and Application of an Experimental Framework to a Plant Pathogen

2018 ◽  
Vol 78 (1) ◽  
pp. 42-56 ◽  
Author(s):  
Anne-Lise Boixel ◽  
Ghislain Delestre ◽  
Jean Legeay ◽  
Michaël Chelle ◽  
Frédéric Suffert
Keyword(s):  
Plant Pathogen ◽  
Concept Development ◽  
Proof Of Concept ◽  
The Individual

A novel clinical applicable bed-side tool for assessing conditioning pain modulation: proof-of-concept

2020 ◽  
Vol 20 (4) ◽  
pp. 801-807
Author(s):  
Lars Arendt-Nielsen ◽  
Jesper Bie Larsen ◽  
Stine Rasmussen ◽  
Malene Krogh ◽  
Laura Borg ◽  
...  
Keyword(s):  
Pain Modulation ◽  
Clinical Settings ◽  
Proof Of Concept ◽  
Finger Nail ◽  
Tonic Stimulus ◽  
Pressure Pain Thresholds ◽  
Custom Made ◽  
The Individual ◽  
Descending Pain Modulation ◽  
Finger Pressure

AbstractBackground and aimsIn recent years, focus on assessing descending pain modulation or conditioning pain modulation (CPM) has emerged in patients with chronic pain. This requires reliable and simple to use bed-side tools to be applied in the clinic. The aim of the present pilot study was to develop and provide proof-of-concept of a simple clinically applicable bed-side tool for assessing CPM.MethodsA group of 26 healthy volunteers participated in the experiment. Pressure pain thresholds (PPT) were assessed as test stimuli from the lower leg before, during and 5 min after delivering the conditioning tonic painful pressure stimulation. The tonic stimulus was delivered for 2 min by a custom-made spring-loaded finger pressure device applying a fixed pressure (2.2 kg) to the index finger nail. The pain intensity provoked by the tonic stimulus was continuously recorded on a 0–10 cm Visual Analog Scale (VAS).ResultsThe median tonic pain stimulus intensity was 6.7 cm (interquartile range: 4.6–8.4 cm) on the 10 cm VAS. The mean PPT increased significantly (P = 0.034) by 55 ± 126 kPa from 518 ± 173 kPa before to 573 ± 228 kPa during conditioning stimulation. When analyzing the individual CPM responses (increases in PPT), a distribution of positive and negative CPM responders was observed with 69% of the individuals classified as positive CPM responders (increased PPTs = anti-nociceptive) and the rest as negative CPM responders (no or decreased PPTs = Pro-nociceptive). This particular responder distribution explains the large variation in the averaged CPM responses observed in many CPM studies. The strongest positive CPM response was an increase of 418 kPa and the strongest negative CPM response was a decrease of 140 kPa.ConclusionsThe present newly developed conditioning pain stimulator provides a simple, applicable tool for routine CPM assessment in clinical practice. Further, reporting averaged CPM effects should be replaced by categorizing volunteers/patients into anti-nociceptive and pro-nociceptive CPM groups.ImplicationsThe finger pressure device provided moderate-to-high pain intensities and was useful for inducing conditioning stimuli. Therefore, the finger pressure device could be a useful bed-side method for measuring CPM in clinical settings with limited time available. Future bed-side studies involving patient populations are warranted to determine the usefulness of the method.

scholarly journals Proof of Concept: Development of Snow Liquid Water Content Profiler Using CS650 Reflectometers at Caribou, ME, USA

Sensors ◽  
2017 ◽  
Vol 17 (3) ◽  
pp. 647 ◽  
Author(s):  
Carlos Pérez Díaz ◽  
Jonathan Muñoz ◽  
Tarendra Lakhankar ◽  
Reza Khanbilvardi ◽  
Peter Romanov
Keyword(s):  
Water Content ◽  
Liquid Water ◽  
Liquid Water Content ◽  
Concept Development ◽  
Proof Of Concept

scholarly journals Extracting Interface Correlations from the Pair Distribution Function of Composite Materials

2021 ◽  
Author(s):  
Harry Geddes ◽  
Henry D. Hutchinson ◽  
Alex R Ha ◽  
Nicholas P. Funnell ◽  
Andrew Goodwin
Keyword(s):  
Distribution Function ◽  
Pair Distribution Function ◽  
Functional Materials ◽  
Model System ◽  
Complex Mixtures ◽  
Proof Of Concept ◽  
X Ray ◽  
The Individual ◽  
Theory And Experiment ◽  
Matrix Factorisation

<div> <div> <div> <p>Using a non-negative matrix factorisation (NMF) approach, we show how the pair distribution function (PDF) of complex mixtures can be deconvolved into the contributions from the individual phase components and also the interface between phases. Our focus is on the model system Fe||Fe3O4. We establish proof-of-concept using idealised PDF data generated from established theory-driven models of the Fe||Fe3O4 interface. Using X-ray PDF measurements for corroded Fe samples, and employing our newly-developed NMF analysis, we extract the experimental interface PDF (‘iPDF’) for this same system. We find excellent agreement between theory and experiment. The implications of our results in the broader context of interface characterisation for complex functional materials are discussed. </p> </div> </div> </div>

The development of concepts through thousands of years

2019 ◽  
pp. 105-112
Author(s):  
Katalin Fried
Keyword(s):  
Mathematics Education ◽  
Prime Number ◽  
Cognitive Processes ◽  
Visual Representation ◽  
Concept Development ◽  
Scientific Content ◽  
Number Concept ◽  
The Everyday ◽  
Development Goals ◽  
The Individual

There are several difficulties when teaching concepts; we have to consider its content, its abstract meaning, its visual representation, verbal and nonverbal aspects of it, etc. Also, the individual content of a concept changes with the knowledge of someone. However, the content of the concepts through the ages vary but education does not necessarily follow the changes. Not talking of the everyday meaning of a concept, this can get stuck at a certain level, while the scientific content changes. The concepts we teach in schools are not necessarily the actual ones. Thus, it is necessary to revise how we teach some of the concepts. One of the most important concepts of this kind is the prime number. Classification: D30, D39, C30, C39. Keywords: Prime number, concept development, goals of mathematics education, cognitive processes.

Proof of Concept Development of a Mobile Spirometer and Breath Sensor

CHEST Journal ◽  
2015 ◽  
Vol 148 (4) ◽  
pp. 892A
Author(s):  
Laren Tan ◽  
Alexander Fung ◽  
Theresa Duong ◽  
Michael Schivo ◽  
JP Delplanque ◽  
...  
Keyword(s):  
Concept Development ◽  
Proof Of Concept

Strong Integration in bilingual grammar, formalized

2018 ◽  
Vol 9 (3) ◽  
pp. 427-467 ◽  
Author(s):  
Lisa Hsin ◽  
Geraldine Legendre
Keyword(s):  
Formal Analysis ◽  
Production Data ◽  
Proof Of Concept ◽  
Interference Effects ◽  
English Bilingual ◽  
Wh Questions ◽  
Linguistic Interference ◽  
The Individual ◽  
As Effects ◽  
Made In

Abstract We present elicited production data reflecting cross-linguistic interference effects in the English wh-questions of Spanish-English bilingual children to provide a proof-of-concept for a proposed new formal analysis of such effects across cross-linguistic influence phenomena. The observed interference effects are interpreted as evidence for the Strong Integration hypothesis of bilingual grammatical architecture, in the context of independently documented facilitation and interference effects in a range of bilingual acquisition contexts. Building on an existing Optimality-Theoretic (OT) model of monolingual acquisition and a specific account of the adult grammar of wh-structures across dialects of Spanish, we propose that the individual patterns documented, in particular the sensitivity in child English to distinctions made in Spanish dialects on the basis of an argument/adjunct contrast, find a straightforward explanation in the OT model of acquisition as adapted to bilingual situations. The generalizability of the model as well as effects of exposure and dominance are discussed.

Sand and shine: an inexpensive method to measure terrestrial arthropod movement in the laboratory

2020 ◽  
Vol 152 (6) ◽  
pp. 823-829
Author(s):  
Alexandre M.M.C. Loureiro ◽  
Vilis O. Nams
Keyword(s):  
Ultraviolet Light ◽  
Ground Beetle ◽  
Computer Software ◽  
Proof Of Concept ◽  
Inexpensive Method ◽  
Human Disturbances ◽  
Video Footage ◽  
Software Applications ◽  
Insect Movement ◽  
The Individual

AbstractUnderstanding what drives insect movement is crucial to understanding how they might be affected by environmental or human disturbances. Methods that measure movement can be expensive, and few are available that do not rely on some sort of video footage. We developed a relatively inexpensive method that allows the user to see the full path of the individual insects within an arena after a certain amount of time, which can be captured with a photograph and later analysed with computer software applications. In our proof-of-concept experiment, we found that the ground beetle, Harpalus rufipes (Coleoptera: Carabidae), was more active in darkness and in light than in ultraviolet light and that it displayed different movement patterns under all three light treatments.

scholarly journals Human-Centric Design of Unified Communications

2018 ◽  
Vol 14 (2) ◽  
pp. 1-18
Author(s):  
Carolina Abrantes ◽  
Óscar Mealha ◽  
Diogo Gomes ◽  
João Paulo Barraca ◽  
José Ferreira
Keyword(s):  
User Experience ◽  
Design Thinking ◽  
Added Value ◽  
Proof Of Concept ◽  
Technology System ◽  
Unified Communications ◽  
Individual Contributions ◽  
The Individual ◽  
Tracking Technology ◽  
Digital Prototype

This article describes a co-design process in the context of user experience (UX) and usability testing and analysis of a first proof of concept of e-collaboration features based on unified communications, co-designed within an organization aiming to optimize users' communication cognitive load. An initial digital prototype with a detailed graphical interface, and simulated user narratives was established and the qualitative validation process is described and discussed. The implemented R&D process is mainly supported on user-centred design (UCD) methodology, namely action research with service design thinking method and co-design techniques. Qualitative data was gathered with concurrent think-aloud activities (CTA) stimulated by user experience expectation questions, observation notes, with integration in an eye tracking technology system. The UCD process and results are discussed, substantiating the added value due to the individual contributions and consequent usefulness of a final unified communication service for the organization.

scholarly journals Project Reporting Management System with AI based Assistive Features for Text Summarization

2021 ◽  
Vol 11 (1) ◽  
pp. 21-27
Author(s):  
Jin Boon Benjamin Tan ◽  
Quan Chen ◽  
Chai Kiat Yeo
Keyword(s):  
Language Processing ◽  
Management System ◽  
Text Summarization ◽  
Research Centre ◽  
Proof Of Concept ◽  
Executive Summary ◽  
Concept System ◽  
Online Submission ◽  
Progress Reporting ◽  
The Individual

This paper details a proof-of-concept system called Project Reporting Management System (PRMS) to manage the project reporting process in a typical research centre where the process can be manual for many centres. In fact, it is general enough to be scaled up and deployed for a large department or scaled down for a smaller setup in any organization which needs a simple and efficient project progress reporting system but does not entail the kind of complexity and cost of commercial project management systems. Using a research centre scenario, the progress of the individual projects has to be tracked through the periodic submission of progress reports by the Principal Investigator (PI) of the project. The centre will need to consolidate these individual reports manually into a consolidated report and an executive summary for higher management. PRMS automates the tracking of individual projects and reporting deadlines, sends reminders and allows online submission of reports by the PIs. PRMS also incorporates assistive and automated features exploiting Machine Learning (ML) and Natural Language Processing (NLP) techniques to generate the consolidated report and rank sentences of verbose report for assistive text summarization to facilitate the manual process of producing an executive summary.

Sign in / Sign up

Export Citation Format

Share Document