Crucial role of N-terminal residue of binding peptides in recognition of the monoclonal antibody specific for the peptide-HLA-B5, -B35 complex

1997 ◽  
Vol 47 (2) ◽  
pp. 149-158 ◽  
Author(s):  
T. Sakaguchi ◽  
Y. Takamiya ◽  
Michael Edidin ◽  
Kiyoshi Nokihara ◽  
Kiyoshi Miwa ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Crucial Role ◽  
Terminal Residue ◽  
Binding Peptides

The Role of Rituximab in the Treatment of Myasthenia Gravis

2010 ◽  
Vol 5 (2) ◽  
pp. 95 ◽  
Author(s):  
Olivier Benveniste ◽  
David Hilton-Jones ◽  
◽  
Keyword(s):  
Rheumatoid Arthritis ◽  
Monoclonal Antibody ◽  
B Cells ◽  
Myasthenia Gravis ◽  
B Cell ◽  
Predictive Factors ◽  
Crucial Role ◽  
Efficacy And Safety ◽  
Off Label

Rituximab, a chimaeric monoclonal antibody against CD20, depletes B cells. It was initially approved for the treatment of B-cell lymphomas, but more recently has been approved for use in rheumatoid arthritis. It has been used extensively ‘off-label’ for the treatment of other autoimmune diseases with some evidence of efficacy, but there remain some as yet unanswered concerns about safety. Myasthenia gravis is the paradigm of an antibody-mediated disorder, and B cells are believed to play a crucial role. This article reviews experience of the efficacy and safety of rituximab in myasthenia gravis and considers predictive factors for the success and failure of rituximab in this disease.

Enkephalin-degrading enzyme inhibitors Crucial role of the C-terminal residue on the inhibitory potencies of retro-hydroxamate dipeptides

2009 ◽  
Vol 33 (2) ◽  
pp. 146-153 ◽  
Author(s):  
MARIE-CLAUDE FOURNIÉ-ZALUSKI ◽  
JEAN-FRANÇOIS HERNANDEZ ◽  
JEAN-MARC SOLEILHAC ◽  
NATHALIE RENWART ◽  
JACQUES PEYROUX ◽  
...  
Keyword(s):  
Crucial Role ◽  
Enzyme Inhibitors ◽  
Degrading Enzyme ◽  
Terminal Residue

Polarized distribution of Na,K-ATPase in honeybee photoreceptors is maintained by interaction with glial cells

1993 ◽  
Vol 105 (2) ◽  
pp. 287-301 ◽  
Author(s):  
O. Baumann ◽  
K. Takeyasu
Keyword(s):  
Monoclonal Antibody ◽  
Glial Cells ◽  
Crucial Role ◽  
Sodium Pump ◽  
Alpha Subunit ◽  
Membrane Domains ◽  
Sodium Pumps ◽  
Polarized Cells ◽  
Surface Domains

Arthropod photoreceptors are polarized cells displaying distinct surface domains. The distribution of the Na,K-ATPase (sodium pump) over these domains was examined in the honeybee photoreceptor using a monoclonal antibody that specifically recognizes the sodium pump alpha-subunit (approximately 100 kDa). We find that the sodium pump is restricted to sites of the nonreceptive photoreceptor surface closely juxtaposed to glial cells; no sodium pumps were detected on the glia-free domains of the nonreceptive surface and on the light-sensitive microvillar membranes. In order to determine the role of photoreceptor-glia contact in maintaining this polarized pump distribution, we assayed the distribution of the Na,K-ATPase after experimentally influencing photoreceptor-glia contact. Sodium pumps were present on the entire nonreceptive photoreceptor surface when photoreceptor-glia contact was removed by isolating the photoreceptors. Remodeling photoreceptor-glia contact by incubation in hyperosmotic saline caused a redistribution of sodium pumps on the photoreceptor surface corresponding to the redistribution of glial cells. We show, further, that both photoreceptor-glia contact and Na,K-ATPase distribution are independent of extracellular Ca2+. No junctional structures were observed at the borders between Na,K-ATPase-positive and Na,K-ATPase-negative membrane domains. Together, these results suggest that adhesion of glial cells to the photoreceptors plays a crucial role in the maintenance of the polarized distribution of Na,K-ATPase in the honeybee photoreceptors. The Ca(2+)-independent adhesion of glial cells to the photoreceptor surface may trap the pump molecules at the sites of photoreceptor-glia contact.

scholarly journals Requirement of c-kit for development of intestinal pacemaker system

Development ◽  
1992 ◽  
Vol 116 (2) ◽  
pp. 369-375 ◽  
Author(s):  
H. Maeda ◽  
A. Yamagata ◽  
S. Nishikawa ◽  
K. Yoshinaga ◽  
S. Kobayashi ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Smooth Muscle ◽  
Receptor Tyrosine Kinase ◽  
Crucial Role ◽  
Functional Role ◽  
Mutant Mice ◽  
Cell Lineages ◽  
Kinase C ◽  
Physiological Analysis

A discovery that the protooncogene encoding the receptor tyrosine kinase, c-kit, is allelic with the Dominant white spotting (W) locus establishes that c-kit plays a functional role in the development of three cell lineages, melanocyte, germ cell, and hematopoietic cell which are defective in W mutant mice. Recent analyses of c-kit expression in various tissues of mouse, however, have demonstrated that c-kit is expressed in more diverse tissues which are phenotypically normal in W mutant mice. Thus, whether or not c-kit expressed outside the three known cell lineages plays a functional role is one of the important questions needing answering in order to fully elucidate the role of c-kit in the development of the mouse. Here, we report that some of the cells in smooth muscle layers of developing intestine express c-kit. Blockade of its function for a few days postnatally by an antagonistic anti-c-kit monoclonal antibody (mAb) results in a severe anomaly of gut movement, which in BALB/c mice produces a lethal paralytic ileus. Physiological analysis indicates that the mechanisms required for the autonomic pacing of contraction in an isolated gut segment are defective in the anti-c-kit mAb-treated mice, W/Wv mice and even W/+ mice. These findings suggest that c-kit plays a crucial role in the development of a component of the pacemaker system that is required for the generation of autonomic gut motility.

Epitaxial YBa2Cu3O7-8 films : Crucial role of growth-induced linear defects in microwave properties

2001 ◽  
Vol 11 (PR11) ◽  
pp. Pr11-47-Pr11-52
Author(s):  
V. M. Pan ◽  
V. S. Flis ◽  
V. A. Komashko ◽  
O. G. Plys ◽  
C. G. Tretiatchenko ◽  
...  
Keyword(s):  
Crucial Role ◽  
Microwave Properties ◽  
Linear Defects

ANALISIS YURIDIS PUTUSAN PENGADILAN NEGERI BLORA TENTANG DUALISME KEPENGURUSAN YAYASAN PENDIDIKAN ISLAM KARTAYUDA YANG AKTA PENDIRIANNYA DIBUAT OLEH DAN DIHADAPAN NOTARIS (Studi Kasus Putusan Perkara PN Blora No. 34/Pdt.G/2015/PN.Bla)

Jurnal Akta ◽  
2017 ◽  
Vol 4 (3) ◽  
pp. 463
Author(s):  
Muslim Ansori ◽  
Akhmad Khisni
Keyword(s):  
Private Schools ◽  
Education System ◽  
Crucial Role ◽  
The State ◽  
Educational Institutions ◽  
Legal Entity ◽  
Non Profit ◽  
The Right

With the enactment of the Education System Act no 20 of 2003 (better known as the Sisdiknas Act), the State has determined that educational institutions should have a legal umbrella in the form of a legal entity, or better known as the Legal Entity Education. As a non-profit organization, the Foundation is the right legal entity that becomes a place for educational institutions, especially private schools. Therefore, of course, Notary has a very crucial role in making notary deed in the form of establishment and deed of change, such as example how in making the right basic budget and not multi interpresatasi for stake holders in the foundation. Therefore, the role of function and authority of the organ of the foundation must be clearly stated in the articles of association, so as not to cause a dispute in the future.KEYWORDS: Notaries, Foundation, Organ Foundation,

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