Heat and light stresses affect metabolite production in the fruit body of the medicinal mushroom Cordyceps militaris

2018 ◽  
Vol 102 (10) ◽  
pp. 4523-4533 ◽  
Author(s):  
Zhang Jiaojiao ◽  
Wang Fen ◽  
Liu Kuanbo ◽  
Liu Qing ◽  
Yang Ying ◽  
...  
Keyword(s):  
Fruit Body ◽  
Cordyceps Militaris ◽  
Medicinal Mushroom ◽  
Metabolite Production

scholarly journals Enhanced Cordycepin Production in Caterpillar Medicinal Mushroom, Cordyceps militaris (Ascomycetes), Mutated by a Multifunctional Plasma Mutagenesis System

2020 ◽  
Vol 22 (12) ◽  
pp. 1147-1159
Author(s):  
Hucheng Zhang ◽  
Lina Deng ◽  
Zhengtian Zhang ◽  
Yusen Guan ◽  
Bo Li ◽  
...  
Keyword(s):  
Cordyceps Militaris ◽  
Medicinal Mushroom

Cordyceps militaris fruit body extract ameliorates membranous glomerulonephritis by attenuating oxidative stress and renal inflammation via the NF-κB pathway

2016 ◽  
Vol 7 (4) ◽  
pp. 2006-2015 ◽  
Author(s):  
Jingjing Song ◽  
Yingwu Wang ◽  
Chungang Liu ◽  
Yan Huang ◽  
Liying He ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Fruit Body ◽  
Membranous Glomerulonephritis ◽  
Cordyceps Militaris ◽  
Adult Patients ◽  
Renal Inflammation ◽  
Nephritic Syndrome ◽  
Body Extract ◽  
Common Pathogenesis

Membranous glomerulonephritis (MGN) is a common pathogenesis of nephritic syndrome in adult patients.

scholarly journals Polysaccharides Obtained from Cordyceps militaris Alleviate Hyperglycemia by Regulating Gut Microbiota in Mice Fed a High-Fat/Sucrose Diet

Foods ◽  
2021 ◽  
Vol 10 (8) ◽  
pp. 1870
Author(s):  
Bao-Hong Lee ◽  
Chia-Hsiu Chen ◽  
Yi-Yun Hsu ◽  
Pei-Ting Chuang ◽  
Ming-Kuei Shih ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Gut Microbiota ◽  
Fruit Body ◽  
Cordyceps Militaris ◽  
Health Food ◽  
High Fat ◽  
The Metabolic Syndrome ◽  
Intestinal Dysbiosis ◽  
Sucrose Diet ◽  
Body Weight Increase

Polysaccharides isolated from fungus Cordyceps militaris display multi-biofunctions, such as immunostimulation, down-regulation of hyperlipidemia, and anti-cancer function. The occurrence of obesity and metabolic syndrome is related to the imbalance of gut microbiota. In this study, the effects of C. militaris and its fractions on modifying metabolic syndrome in mice were evaluated. Mice were fed a high-fat/high-sucrose diet (HFSD) for 14 weeks to induce body weight increase and hyperlipidemia symptoms in mice, and then the mice were simultaneously given a HFSD and C. militaris samples for a further 8 weeks. The results indicated that the fruit body, polysaccharides, and cordycepin obtained from C. militaris had different efficacies on regulating metabolic syndrome and gut microbiota in HFSD-treated mice. Polysaccharides derived from C. militaris decreased the levels of blood sugar and serum lipids in mice fed HFSD. In addition, C. militaris-polysaccharide treatment obviously improved intestinal dysbiosis through promoting the population of next generation probiotic Akkermansia muciniphila in the gut of mice fed HFSD. In conclusion, polysaccharides derived from C. militaris have the potential to act as dietary supplements and health food products for modifying the gut microbiota to improve the metabolic syndrome.

scholarly journals Biomass and Cordycepin Production by the Medicinal Mushroom Cordyceps militaris—A Review of Various Aspects and Recent Trends towards the Exploitation of a Valuable Fungus

2021 ◽  
Vol 7 (11) ◽  
pp. 986
Author(s):  
Dimitrios Kontogiannatos ◽  
Georgios Koutrotsios ◽  
Savvina Xekalaki ◽  
Georgios I. Zervakis
Keyword(s):  
Large Scale ◽  
Fruit Body ◽  
Cordyceps Militaris ◽  
Economic Losses ◽  
Ophiocordyceps Sinensis ◽  
Wide Range ◽  
Significant Research ◽  
Caterpillar Fungus ◽  
Recent Trends ◽  
Large Scale Cultivation

Cordyceps militaris is an entomopathogenic ascomycete with similar pharmacological importance to that of the wild caterpillar fungus Ophiocordyceps sinensis. C. militaris has attracted significant research and commercial interest due to its content in bioactive compounds beneficial to human health and the relative ease of cultivation under laboratory conditions. However, room for improvement exists in the commercial-scale cultivation of C. militaris and concerns issues principally related to appropriate strain selection, genetic degeneration of cultures, and substrate optimization. In particular, culture degeneration—usually expressed by abnormal fruit body formation and reduced sporulation—results in important economic losses and is holding back investors and potential growers (mainly in Western countries) from further developing this highly promising sector. In the present review, the main factors that influence the generation of biomass and metabolites (with emphasis on cordycepin biosynthesis) by C. militaris are presented and evaluated in conjunction with the use of a wide range of supplements or additives towards the enhancement of fungal productivity in large-scale cultivation processes. Moreover, physiological and genetic factors that increase or reduce the manifestation of strain degeneration in C. militaris are outlined. Finally, methodologies for developing protocols to be used in C. militaris functional biology studies are discussed.

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