The non-canonical functions of telomerase reverse transcriptase gene GlTert on regulating fungal growth, oxidative stress, and ganoderic acid biosynthesis in Ganoderma lucidum

2021 ◽  
Author(s):  
Guang Zhang ◽  
Chaohui Zhang ◽  
Doudou Leng ◽  
Peng Yan ◽  
Zhenhe Wang ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Reverse Transcriptase ◽  
Ganoderma Lucidum ◽  
Fungal Growth ◽  
Telomerase Reverse Transcriptase ◽  
Reverse Transcriptase Gene ◽  
Acid Biosynthesis ◽  
Ganoderic Acid

Non-canonical Functions of Telomerase Reverse Transcriptase: Emerging Roles and Biological Relevance

2020 ◽  
Vol 20 (6) ◽  
pp. 498-507 ◽  
Author(s):  
Connor A.H. Thompson ◽  
Judy M.Y. Wong
Keyword(s):  
Oxidative Stress ◽  
Dna Damage ◽  
Reverse Transcriptase ◽  
Cancer Cells ◽  
Telomere Length ◽  
Telomere Maintenance ◽  
Telomerase Reverse Transcriptase ◽  
Alternative Mechanism ◽  
Dependent Manner ◽  
Mitochondrial Integrity

Increasing evidence from research on telomerase suggests that in addition to its catalytic telomere repeat synthesis activity, telomerase may have other biologically important functions. The canonical roles of telomerase are at the telomere ends where they elongate telomeres and maintain genomic stability and cellular lifespan. The catalytic protein component Telomerase Reverse Transcriptase (TERT) is preferentially expressed at high levels in cancer cells despite the existence of an alternative mechanism for telomere maintenance (alternative lengthening of telomeres or ALT). TERT is also expressed at higher levels than necessary for maintaining functional telomere length, suggesting other possible adaptive functions. Emerging non-canonical roles of TERT include regulation of non-telomeric DNA damage responses, promotion of cell growth and proliferation, acceleration of cell cycle kinetics, and control of mitochondrial integrity following oxidative stress. Non-canonical activities of TERT primarily show cellular protective effects, and nuclear TERT has been shown to protect against cell death following double-stranded DNA damage, independent of its role in telomere length maintenance. TERT has been suggested to act as a chromatin modulator and participate in the transcriptional regulation of gene expression. TERT has also been reported to regulate transcript levels through an RNA-dependent RNA Polymerase (RdRP) activity and produce siRNAs in a Dicer-dependent manner. At the mitochondria, TERT is suggested to protect against oxidative stress-induced mtDNA damage and promote mitochondrial integrity. These extra-telomeric functions of TERT may be advantageous in the context of increased proliferation and metabolic stress often found in rapidly-dividing cancer cells. Understanding the spectrum of non-canonical functions of telomerase may have important implications for the rational design of anti-cancer chemotherapeutic drugs.

Tissue-specific expression of telomerase reverse transcriptase gene variants in Nicotiana tabacum

Planta ◽  
2016 ◽  
Vol 245 (3) ◽  
pp. 549-561 ◽  
Author(s):  
Jana Fišerová Jurečková ◽  
Eva Sýkorová ◽  
Said Hafidh ◽  
David Honys ◽  
Jiří Fajkus ◽  
...  
Keyword(s):  
Nicotiana Tabacum ◽  
Reverse Transcriptase ◽  
Telomerase Reverse Transcriptase ◽  
Gene Variants ◽  
Reverse Transcriptase Gene ◽  
Specific Expression ◽  
Tissue Specific ◽  
Tissue Specific Expression

scholarly journals Alternative oxidase impacts ganoderic acid biosynthesis by regulating intracellular ROS levels in Ganoderma lucidum

Microbiology ◽  
2017 ◽  
Vol 163 (10) ◽  
pp. 1466-1476 ◽  
Author(s):  
Deng-Ke Shi ◽  
Jing Zhu ◽  
Ze-Hua Sun ◽  
Guang Zhang ◽  
Rui Liu ◽  
...  
Keyword(s):  
Ganoderma Lucidum ◽  
Alternative Oxidase ◽  
Acid Biosynthesis ◽  
Ganoderic Acid ◽  
Intracellular Ros

Telomerase reverse transcriptase gene amplification in hepatocellular carcinoma

2004 ◽  
Vol 19 (11) ◽  
pp. 1300-1304 ◽  
Author(s):  
YOSHITAKA TAKUMA ◽  
KAZUHIRO NOUSO ◽  
YOSHIYUKI KOBAYASHI ◽  
SHINICHIRO NAKAMURA ◽  
HIRONORI TANAKA ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Reverse Transcriptase ◽  
Gene Amplification ◽  
Telomerase Reverse Transcriptase ◽  
Reverse Transcriptase Gene
Sign in / Sign up

Export Citation Format

Share Document