Surfactin-oleogel with therapeutic potential for inflammatory acne vulgaris induced by Propionibacterium acnes

2021 ◽  
Author(s):  
Mengyuan Shan ◽  
Fanqiang Meng ◽  
Chao Tang ◽  
Libang Zhou ◽  
Zhaoxin Lu ◽  
...  
Keyword(s):  
Propionibacterium Acnes ◽  
Therapeutic Potential ◽  
Acne Vulgaris

Cosmoceutical and Therapeutic Potential of Isotretinoin Nanoparticulate Gel in Management of Acne

2018 ◽  
Vol 4 (1-2) ◽  
Author(s):  
Jovita Kanoujia ◽  
Alok Kumar Yadav ◽  
Priyanka Maurya ◽  
Samipta Singh ◽  
Abhishek Yadav ◽  
...  
Keyword(s):  
Staphylococcus Epidermidis ◽  
Propionibacterium Acnes ◽  
Therapeutic Potential ◽  
Acne Vulgaris ◽  
Chitosan Nanoparticles ◽  
In Vitro Drug Release ◽  
Ionic Crosslinking ◽  
Sebum Production ◽  
Average Size

This study intended to develop and evaluate isotretinoin (ITR) loaded nanoparticles taking chitosan as a polymer of interest. Ionic crosslinking method was utilized to prepare nanoparticles. Nanoparticles were formulated using varying ratios (chitosan: tripolyphosphate) and evaluated for its size, distribution of size, zeta potential, percentage of ITR entrapped within nanoparticles, in vitro drug release and its stability under accelerated conditions. The prepared nanoparticles (NPs) were spherical, white in color and free flowing, 321± 4.5 nm was the average size of optimized chitosan nanoparticles and it was able to entrap 88.76 ± 3.5%. The outcomes assured vast promise of the CNs of ITR (optimized) in management of acne and also increasing the therapeutic efficacy, thus establish to be a promising, effective and patient compliant formulation. INTRODUCTION Acne, a cutaneous pleomorphic condition of the pilosebaceous unit involving sebum production rate anomaly and described by inflammatory (pustules, nodules and papules) as well as non-inflammatory comedones (closed and/or open)(Knutson, 1974). Regular pus-forming microbes Propionibacterium acnes and Staphylococcus epidermidis are responsible for development of many forms of acne vulgaris(Rawat, Tripathi et al., 2015). It is a pleomorphic disorder and can manifest at any time during life but it most commonly occurs between ages of 12-24 years, accounting effective 85% of population (Cordain, Lindeberg et al., 2002). P. acne is an anaerobic microorganismexisting in acne lesionsthat promotes inflammation through a variety of mechanisms and involved inproducing pro-inflammatory mediators that diffuses through the follicle wall (Itoh, Tsuchida et al., 2014). Prominent in adolescence and puberty, acne is definitely associated with function of sebaceous gland, which stimulate higher secretion of sebum androgenically (Singh, Gangwar et al., 2016).However, the consequential sebaceous

scholarly journals Antimicrobial Property of Lauric Acid Against Propionibacterium Acnes: Its Therapeutic Potential for Inflammatory Acne Vulgaris

2009 ◽  
Vol 129 (10) ◽  
pp. 2480-2488 ◽  
Author(s):  
Teruaki Nakatsuji ◽  
Mandy C. Kao ◽  
Jia-You Fang ◽  
Christos C. Zouboulis ◽  
Liangfang Zhang ◽  
...  
Keyword(s):  
Lauric Acid ◽  
Propionibacterium Acnes ◽  
Therapeutic Potential ◽  
Acne Vulgaris ◽  
Antimicrobial Property

Citrula Gel dari Limbah Kulit Buah Semangka (Citrullus lanatus (Thunb.) Matsum & Nakai) sebagai Antijerawat (Acne vulgaris)

2019 ◽  
Vol 16 (1) ◽  
pp. 74
Author(s):  
Yola Anggraeni ◽  
Tika Ambarwati ◽  
Irmas Miranti ◽  
Erza Genatrika
Keyword(s):  
Staphylococcus Aureus ◽  
Propionibacterium Acnes ◽  
Citrullus Lanatus ◽  
Acne Vulgaris ◽  
Carbopol 940

Jerawat  didefinisikan  sebagai  peradangan  kronik  dari  folikel  polisebasea  yang disebabkan  oleh  beberapa  faktor  dengan  gambaran  klinis  yang  khas.  Salah  satu tanaman  yang  dapat  mengatasi  jerawat  yaitu semangka.  Kulit buah semangka (Citrullus lanatus (Thunb.) Matsum & Nakai) memiliki   senyawa antibakteri di antaranya  alkaloid,  fenol,  saponin,  dan  terpenoid.  Dalam penelitian ini ekstrak limbah  kulit  buah semangka diformulasikan   dalam   sediaan   gel.   Tahap   penelitian   yang menggunakan  rancangan  acak  lengkap ini meliputi  penyiapan  dan  pengumpulan simplisia   limbah   kulit   buah   semangka,   ekstraksi,   uji kandungan senyawa, formulasi gel, evaluasi sifat fisik sediaan gel, dan uji aktivitas antibakteri  terhadap  bakteri  Propionibacterium acnes  dan  Staphylococcus  aureus. Ekstraksi yang dilakukan adalah dengan menggunakan metode maserasi dengan penyari kloroform. Uji kandungan senyawa dilakukan dengan menggunakan metode penapisan fitokimia meliputi uji alkaloid, uji triterpenoid, uji fenol, dan uji saponin. Ekstrak kulit buah semangka dengan konsentrasi 5, 10, dan 15% kemudian diformulasikan dengan carbopol 940 dan dilanjutkan dengan evaluasi sifat fisik gel, di antaranya uji organoleptis, uji homogenitas, uji daya sebar, uji daya lekat, uji pH, dan uji viskositas. Uji aktivitas antibakteri dari formulasi ekstrak kulit buah semangka dilakukan dengan menggunakan metode difusi agar. Hasil formulasi terbaik pada formulasi gel menghasilkan gel yang homogen, lekat, menyebar, pH yang cocok dengan kulit, dan memiliki viskositas yang cukup baik. Hasil terbaik dari zona hambat uji antibakteri pada bakteri Propionibacterium acnes yaitu 5,23 mm dan pada bakteri Staphylococcus  aureus yaitu 5,80 mm.

scholarly journals Oligochitosan as a potential anti-acne vulgaris agent: combined antibacterial effects against Propionibacterium acnes

2017 ◽  
Vol 26 (4) ◽  
pp. 1029-1036 ◽  
Author(s):  
Song-Hee Kim ◽  
Sung-Hwan Eom ◽  
Daeung Yu ◽  
Myung-Suk Lee ◽  
Young-Mog Kim
Keyword(s):  
Propionibacterium Acnes ◽  
Acne Vulgaris ◽  
Antibacterial Effects

scholarly journals a) Influência do índice de massa corporal e da dieta na fisiopatologia da Acne Vulgaris

2017 ◽  
Vol 75 (3) ◽  
Author(s):  
José Pedro Oliveira Pinheiro da Silva ◽  
Glória Maria Cardoso da Cunha Velho
Keyword(s):  
Growth Factor ◽  
Propionibacterium Acnes ◽  
Acne Vulgaris ◽  
Malassezia Furfur ◽  
Insulin Like Growth Factor ◽  
Forkhead Box

Acne vulgaris é uma das patologias dermatológicas mais comuns na população geral, principalmente em adolescentes e jovens adultos. Esta patologia afeta os folículos pilossebáceos através de processos de hiperqueratose, hipersecreção sebácea, colonização microbiana (Propionibacterium acnes e Malassezia furfur) e mecanismos imunológicos e pode ser descrita tanto como inflamatória (pápulas, pústulas ou nódulos) ou não inflamatória (comedões abertos ou fechados). Apesar de não existir mortalidade associada, existe normalmente significativa morbilidade física e psicológica, como cicatrizes permanentes, baixa autoestima, depressão e ansiedade. A fisiopatologia desta doença é multifatorial, sendo que vários estudos provam a importância de vários fatores genéticos e não genéticos, como diversos mecanismos reguladores endócrinos e a dieta, no aparecimento da acne. Estudos associam a dieta ocidental (carbohidratos hiperglicémicos, leite e lacticínios e gorduras saturadas) e o índice de massa corporal excessivo (excesso de peso e obesidade) ao aparecimento de Acne Vulgaris, sendo que existe evidência do papel da hiperinsulinémia e da resistência à insulina nesta associação. Será assim avaliada nesta dissertação a atual literatura que aborda a fisiopatologia da Acne Vulgaris, com especial foco na relação entre os reguladores endócrinos (androgénios e insulin-like growth factor 1) e reguladores celulares (Forkhead box protein 01, kinase proteica Akt) e os diferentes alimentos da dieta, dando relevância às peculiaridades da dieta ocidental e do seu papel no aparecimento de acne nas diferentes pool´s genéticas mundiais. Será também explorada a relação entre o índice de massa corporal e o aparecimento de acne, bem como a importância das adipocinas na etiologia da acne. O objetivo deste trabalho é contribuir para o melhor conhecimento da fisiopatologia desta interessante e frequente patologia. Sendo uma área muito estudada, torna-se fulcral a existência de artigos de revisão, que compilem, sintetizem e ao mesmo tempo analisem criticamente a literatura científica existente.

scholarly journals Hubungan antara Mencuci Wajah dengan Kejadian Akne Vulgaris pada Remaja Laki-laki di Manado

e-CliniC ◽  
2019 ◽  
Vol 8 (1) ◽  
Author(s):  
Fifin R. T. Sole ◽  
Pieter L. Suling ◽  
Tara S. Kairupan
Keyword(s):  
Propionibacterium Acnes ◽  
Acne Vulgaris ◽  
Adolescent Males ◽  
Personal Hygiene ◽  
P Value ◽  
Chi Square ◽  
Cross Sectional ◽  
Severe Acne ◽  
Akne Vulgaris ◽  
The Relationship

Abstract: Acne vulgaris is a chronic skin condition involving inflammation of the pilosebaceous follicle. The highest prevalence of acne vulgaris is at the age of 16-17 years. Pathogenic factors contributing to the development of acne vulgaris include increased sebum production, pilosebaceous follicular blockage, and increased colonization of Propionibacterium acnes. Personal hygiene is suggested as an important factor that needs to be maintained in acne prevention. Males tend to lack of awareness to seek information and health services in dealing with acne problems. This study was aimed to evaluate the relationship between facial washing and the incidence of acne vulgaris in adolescent males in Manado. This was an analytical and observational study using a cross-sectional design. Subjects were male students of 3rd grade at SMA Negeri 9 Manado, aged 16-19 years old, and met the inclusion and exclusion criteria, with a total number of 95 students. Subjects who washed their faces 2-3 times a day were 38 students (40%) while those who washed their faces less than twice or more than thrice a day were 57 students (60%). Subjects with no or mild acne vulgaris were 39 students (41.1%), while those with moderate to severe acne vulgaris were 56 students (58.9%). The chi-square showed a p-value of 0.004 for the relationship between the frequency of facial washing and the incidence of acne vulgaris. In conclusion, there was a significant relationship between facial washing and the incidence of acne vulgaris in adolescent males in Manado.Keywords: facial washing, acne vulgaris Abstrak: Akne vulgaris merupakan peradangan kronis folikel pilosebasea dengan prevalensi tertinggi pada usia 16-17 tahun. Faktor yang memengaruhi terjadinya akne vulgaris antara lain peningkatan produksi sebum, penyumbatan folikel pilosebasea, dan peningkatan kolonisasi bakteri Propionibacterium acnes. Kebersihan diri merupakan faktor penting yang perlu dijaga sebagai salah satu usaha untuk mencegah timbulnya akne. Laki-laki cenderung kurang memiliki kesadaran untuk mencari informasi dan pelayanan kesehatan dalam menangani masalah akne. Penelitian ini bertujuan untuk menilai hubungan antara mencuci wajah dengan kejadian akne vulgaris pada remaja laki-laki di Manado. Jenis penelitian ialah observasional analitik dengan desain potong lintang. Subjek penelitian ialah siswa laki-laki kelas 3 di SMA Negeri 9 Manado, usia 16-19 tahun, dan memenuhi kriteria inklusi dan eksklusi, dengan jumlah total 95 siswa. Subjek yang mencuci wajah 2-3 kali sehari sebanyak 38 siswa (40%) sedangkan yang mencuci wajah kurang dari 2 kali atau lebih dari 3 kali sehari sebanyak 57 siswa (60%). Subjek tanpa akne vulgaris atau akne derajat ringan sebanyak 39 siswa (41,1%) sedangkan yang dengan akne vulgaris derajat sedang sampai berat sebanyak 56 siswa (58,9%). Uji chi-square memperlihatkan nilai p=0.004 terhadap hubungan antara frekuensi mencuci wajah dengan kejadian akne vulgaris. Simpulan penelitian ini ialah terdapat hubungan bermakna antara mencuci wajah dengan kejadian akne vulgaris pada remaja laki-laki di Manado.Kata kunci: mencuci wajah, akne vulgaris

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