scholarly journals a) Influência do índice de massa corporal e da dieta na fisiopatologia da Acne Vulgaris

2017 ◽  
Vol 75 (3) ◽  
Author(s):  
José Pedro Oliveira Pinheiro da Silva ◽  
Glória Maria Cardoso da Cunha Velho
Keyword(s):  
Growth Factor ◽  
Propionibacterium Acnes ◽  
Acne Vulgaris ◽  
Malassezia Furfur ◽  
Insulin Like Growth Factor ◽  
Forkhead Box

Acne vulgaris é uma das patologias dermatológicas mais comuns na população geral, principalmente em adolescentes e jovens adultos. Esta patologia afeta os folículos pilossebáceos através de processos de hiperqueratose, hipersecreção sebácea, colonização microbiana (Propionibacterium acnes e Malassezia furfur) e mecanismos imunológicos e pode ser descrita tanto como inflamatória (pápulas, pústulas ou nódulos) ou não inflamatória (comedões abertos ou fechados). Apesar de não existir mortalidade associada, existe normalmente significativa morbilidade física e psicológica, como cicatrizes permanentes, baixa autoestima, depressão e ansiedade. A fisiopatologia desta doença é multifatorial, sendo que vários estudos provam a importância de vários fatores genéticos e não genéticos, como diversos mecanismos reguladores endócrinos e a dieta, no aparecimento da acne. Estudos associam a dieta ocidental (carbohidratos hiperglicémicos, leite e lacticínios e gorduras saturadas) e o índice de massa corporal excessivo (excesso de peso e obesidade) ao aparecimento de Acne Vulgaris, sendo que existe evidência do papel da hiperinsulinémia e da resistência à insulina nesta associação. Será assim avaliada nesta dissertação a atual literatura que aborda a fisiopatologia da Acne Vulgaris, com especial foco na relação entre os reguladores endócrinos (androgénios e insulin-like growth factor 1) e reguladores celulares (Forkhead box protein 01, kinase proteica Akt) e os diferentes alimentos da dieta, dando relevância às peculiaridades da dieta ocidental e do seu papel no aparecimento de acne nas diferentes pool´s genéticas mundiais. Será também explorada a relação entre o índice de massa corporal e o aparecimento de acne, bem como a importância das adipocinas na etiologia da acne. O objetivo deste trabalho é contribuir para o melhor conhecimento da fisiopatologia desta interessante e frequente patologia. Sendo uma área muito estudada, torna-se fulcral a existência de artigos de revisão, que compilem, sintetizem e ao mesmo tempo analisem criticamente a literatura científica existente.

Insulin-like growth factor-1 directly mediates expression of mitochondrial uncoupling protein 3 via forkhead box O4

2019 ◽  
Vol 46-47 ◽  
pp. 24-35
Author(s):  
Yukiko Watamoto ◽  
Kumi Futawaka ◽  
Misa Hayashi ◽  
Midori Matsushita ◽  
Mana Mitsutani ◽  
...  
Keyword(s):  
Growth Factor ◽  
Uncoupling Protein ◽  
Insulin Like Growth Factor ◽  
Mitochondrial Uncoupling ◽  
Mitochondrial Uncoupling Protein ◽  
Forkhead Box ◽  
Uncoupling Protein 3

scholarly journals Role of insulin-like growth factor 1 in pathogenesis of acne vulgaris: relation to acne severity and body mass index

2020 ◽  
Vol 6 (2) ◽  
pp. 147
Author(s):  
Shereen Adel ◽  
Talal A. Abd-El-Raheem ◽  
Ghada Ezzat ◽  
Nermeen M. Ismail
Keyword(s):  
Body Mass Index ◽  
Growth Factor ◽  
Body Mass ◽  
Scientific Evidence ◽  
Acne Vulgaris ◽  
Elevated Serum ◽  
Insulin Like Growth Factor ◽  
Dermatological Examination ◽  
Relationship Of

<div class="Section1"><p class="abstract"><strong>Background:</strong> Acne vulgaris is a multifactorial skin disease. A potential role for insulin-like growth factor-1 (IGF-1) has been suggested in the pathogenesis of acne. Several studies have shown that elevated levels of serum IGF-1 correlate with overproduction of sebum and acne. Objective: Measurement of the serum level of IGF-1 in acne patients in comparison to normal controls and evaluating the relationship of these levels to severity of acne and body mass index (BMI), in order to investigate the role of this factor in the pathogenesis of acne.</p><p class="abstract"><strong>Methods:</strong> Fifty-four patients with acne vulagaris and 42 healthy controls were included. History taking, dermatological examination, clinical assessments of acne severity, calculation of BMI were performed for patients. Blood samples were collected from all participants for estimation of serum IGF-1 level using enzyme linked immunosorbant assay.<strong></strong></p><p class="abstract"><strong>Results:</strong> There was a significantly higher serum IGF-1 level in acne patients (p&lt;0.05) than controls. Authors didn’t find a relation of significance between elevated serum IGF-1 level and degree of acne severity and BMI (p&gt;0.05). There was a significant positive correlation between serum IGF-1 level and age of the patients.</p><p class="abstract"><strong>Conclusions:</strong> There is a significantly higher serum IGF-1 in acne patients than controls not related to acne severity and BMI. That is adding to the scientific evidence of IGF-1 role in pathogenesis of acne vulgaris.</p></div>

Hoxa5 overexpression correlates with IGFBP1 upregulation and postnatal dwarfism: evidence for an interaction between Hoxa5 and Forkhead box transcription factors

Development ◽  
2002 ◽  
Vol 129 (17) ◽  
pp. 4065-4074
Author(s):  
Isabelle Foucher ◽  
Michel Volovitch ◽  
Monique Frain ◽  
J. Julie Kim ◽  
Jean-Claude Souberbielle ◽  
...  
Keyword(s):  
Transcription Factors ◽  
Growth Factor ◽  
Promoter Activity ◽  
Homeobox Gene ◽  
Direct Interaction ◽  
Fold Increase ◽  
Regulatory Elements ◽  
Insulin Like Growth Factor ◽  
Forkhead Box

Transgenic mice expressing the homeobox gene Hoxa5 under the control of Hoxb2 regulatory elements present a growth arrest during weeks two and three of postnatal development, resulting in proportionate dwarfism. These mice present a liver phenotype illustrated by a 12-fold increase in liver insulin-like growth factor binding protein 1 (IGFBP1) mRNA and a 50% decrease in liver insulin-like growth factor 1 (IGF1) mRNA correlated with a 50% decrease in circulating IGF1. We show that the Hoxa5 transgene is expressed in the liver of these mice, leading to an overexpression of total (endogenous plus transgene) Hoxa5 mRNA in this tissue. We have used several cell lines to investigate a possible physiological interaction of Hoxa5 with the main regulator of IGFBP1 promoter activity, the Forkhead box transcription factor FKHR. In HepG2 cells, Hoxa5 has little effect by itself but inhibits the FKHR-dependent activation of the IGFBP1 promoter. In HuF cells, Hoxa5 cooperates with FKHR to dramatically enhance IGFBP1 promoter activity. This context-dependent physiological interaction probably corresponds to the existence of a direct interaction between Hoxa5 and FKHR and FoxA2/HNF3β, as demonstrated by pull-down experiments achieved either in vitro or after cellular co-expression. In conclusion, we propose that the impaired growth observed in this transgenic line relates to a liver phenotype best explained by a direct interaction between Hoxa5 and liver-specific Forkhead box transcription factors, in particular FKHR but also Foxa2/HNF3β. Because Hoxa5 and homeogenes of the same paralog group are normally expressed in the liver, the present results raise the possibility that homeoproteins, in addition to their established role during early development, regulate systemic physiological functions.

Insulin-like growth factor-I gene polymorphism in acne vulgaris

2011 ◽  
Vol 27 (2) ◽  
pp. 254-257 ◽  
Author(s):  
L. Tasli ◽  
S. Turgut ◽  
N. Kacar ◽  
C. Ayada ◽  
M. Coban ◽  
...  
Keyword(s):  
Growth Factor ◽  
Gene Polymorphism ◽  
Acne Vulgaris ◽  
Insulin Like Growth Factor ◽  
Factor I ◽  
Growth Factor I ◽  
I Gene

scholarly journals Serum Level of Insulin-Like Growth Factor 1 in Patients with Acne Vulgaris Versus Healthy Subjects

2018 ◽  
Vol In Press (In Press) ◽  
Author(s):  
Elham Behrangi ◽  
Abbas Rasi ◽  
Parisa Navid ◽  
Behzad Dalvand ◽  
Zahra Azizian
Keyword(s):  
Growth Factor ◽  
Serum Level ◽  
Healthy Subjects ◽  
Acne Vulgaris ◽  
Insulin Like Growth Factor

scholarly journals Hubungan Indeks Massa Tubuh dan Angka Kejadian Akne Vulgaris pada Siswa-siswi di SMA Frater Don Bosco Manado

e-CliniC ◽  
2017 ◽  
Vol 5 (2) ◽  
Author(s):  
Ni M.S. Kristiani ◽  
Marlyn G. Kapantouw ◽  
Thigita A. Pandaleke
Keyword(s):  
Body Mass Index ◽  
Growth Factor ◽  
Body Mass ◽  
Acne Vulgaris ◽  
Chronic Inflammatory Disease ◽  
Insulin Like Growth Factor ◽  
Hormone Production ◽  
Cross Sectional ◽  
Cross Sectional Design ◽  
Akne Vulgaris

Abstract: Acne vulgaris is a chronic inflammatory disease of the pilosebasea follicle. Although the cause of acne vulgaris is not known for certain but there are several pathogenesis suspected to have some effects on the occurrence of acne vulgaris, inter alia the increase in sebum production which is controlled by androgen hormones. Stimulation of androgen hormone production is associated with elevated level of insulin-like growth factor-1 (IGF-1). Increased IGF-1 is correlated positively with body mass index (BMI). In general, acne vulgaris begins at age 12-15 years and most occur in adolescents aged 15-18 years. This study was aimed to determine the relationship between BMI and the incidence rate of acne vulgaris in students at SMA Frater Don Bosco Manado (senior high school). This was an analytical survey observation with a cross sectional design. Subjects were 69 students obtained by using systematic random sampling. Of the 69 students suffered from acne vulgaris, there were 8 (11.6%) with thin BMI; 50 (72.5%) with normal BMI; and 11 (15.9%) with fat and obese BMI. Conclusion: There was no significant association between BMI and the incidence of acne vulgaris among the students at SMA Frater Don Bosco Manado.Keywords: body mass index, acne vulgaris Abstrak: Akne vulgaris adalah penyakit radang kronis pada folikel pilosebasea. Walaupun penyebab dari akne vulgaris belum diketahui pasti namun terdapat beberapa patogenesis yang diduga berpengaruh pada timbulnya akne vulgaris, salah satunya yaitu peningkatan produksi sebum di bawah kontrol hormon androgen. Stimulasi produksi hormon androgen berhubungan dengan peningkatan kadar insulin-like growth factor-1 (IGF-1). Peningkatan IGF-1 berkorelasi positif dengan indeks massa tubuh (IMT). Umumnya akne vulgaris dimulai pada usia 12-15 tahun dan terbanyak pada remaja usia 15-18 tahun. Penelitian ini bertujuan untuk mengetahui hubungan antara IMT dan angka kejadian akne vulgaris pada siswa-siswi di SMA Frater Don Bosco Manado. Jenis penelitian ialah observasi analitik survei dengan desain potong lintang. Subyek penelitian ialah siswa-siswi di SMA Frater Don Bosco Manado diperoleh dengan pengambilan sampel secara acak sistematis. Pada 69 subyek dengan akne vulgaris, terdapat 8 orang (11,6%) dengan IMT kurus; 50 orang (72,5%) dengan IMT normal; dan 11 orang (15,9%) dengan IMT gemuk dan obesitas. Simpulan: Tidak terdapat hubungan bermakna antara IMT dan angka kejadian akne vulgaris pada siswa-siswi di SMA Frater Don Bosco Manado.Kata kunci: indeks massa tubuh, akne vulgaris

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