Enhanced production of pigment-free pullulan by a morphogenetically arrested Aureobasidium pullulans (ATCC 42023) in a two-stage fermentation with shift from soy bean oil to sucrose

1995 ◽  
Vol 43 (4) ◽  
pp. 595-603
Author(s):  
Y. Shabtai ◽  
I. Mukmenev
2009 ◽  
Vol 26 (4) ◽  
pp. 737-741 ◽  
Author(s):  
Shengjun Wu ◽  
Hanqing Chen ◽  
Zhengyu Jin ◽  
Qunyi Tong

2014 ◽  
Vol 152 ◽  
pp. 162-168 ◽  
Author(s):  
Yi-Xiang Zhu ◽  
Ling-Yun Yao ◽  
Rui-Hua Jiao ◽  
Yan-Hua Lu ◽  
Ren-Xiang Tan

2019 ◽  
Vol 68 (2) ◽  
pp. 561-566 ◽  
Author(s):  
Sheng-Jie Yue ◽  
Peng Huang ◽  
Song Li ◽  
Malik Jan ◽  
Hong-Bo Hu ◽  
...  

RSC Advances ◽  
2019 ◽  
Vol 9 (45) ◽  
pp. 26532-26536 ◽  
Author(s):  
Yifeng Yang ◽  
Yilin Hou ◽  
Zhaohui Chen ◽  
Huiqiu Wang ◽  
Yu Wang ◽  
...  

High-yield production of aromatics from propane with a temperature shifting, two-stage fluidized bed reactor technology.


2007 ◽  
Vol 292 (5) ◽  
pp. L1233-L1240 ◽  
Author(s):  
Navneet Kaur Dhillon ◽  
David Pinson ◽  
Sukhbir Dhillon ◽  
Ossama Tawfik ◽  
Marsha Danley ◽  
...  

Pneumonia is a major complication of human immunodeficiency virus (HIV) pathogenesis but it develops only after prolonged infection. We used the macaque model to explore a hypothesis that the disease is a two-stage process, the first stage being establishment of the viral infection in the lung and the second being amplification of virus replication by host factors induced by chemical agents or opportunistic pathogens in the lung. Bleomycin, a chemical known to induce diffuse alveolar damage and pulmonary fibrosis with accumulation of macrophages and a rich T helper type 2 (Th2) cytokine environment, was inoculated intratracheally into five of eight SHIV 89.6P-infected macaques and into one uninfected macaque. Three additional simian HIV (SHIV)-infected macaques without bleomycin treatment served as untreated virus controls. Although none of the animals became clinically ill, bleomycin induced classical host responses in the lungs of all the treated, virus-infected macaques. There was enhanced production of the chemokine, monocyte chemotactic protein-1 (MCP-1), that had previously been shown to cause enhanced replication of the virus. Four of the five treated animals developed more productive SHIV infection in the lungs compared with the infected untreated animals. Enhanced virus replication was found primarily in infiltrating macrophages. Enhanced replication of the virus in the lungs was associated with host factors induced by the drug and supported the hypothesis for a two-stage process of pulmonary pathogenesis.


2020 ◽  
Vol 104 (16) ◽  
pp. 7155-7164
Author(s):  
Wenjuan Song ◽  
Yuyi Yang ◽  
Xinjin Liang ◽  
Feixue Liu ◽  
Geoffrey Michael Gadd

Abstract Aureobasidium pullulans is a ubiquitous and widely distributed fungus in the environment, and exhibits substantial tolerance against toxic metals. However, the interactions between metals and metalloids with the copious extracellular polymeric substances (EPS) produced by A. pullulans and possible relationships to tolerance are not well understood. In this study, it was found that mercury (Hg) and selenium (Se), as selenite, not only significantly inhibited growth of A. pullulans but also affected the composition of produced EPS. Lead (Pb) showed little influence on EPS yield or composition. The interactions of EPS from A. pullulans with the tested metals and metalloids depended on the specific element and their concentration. Fluorescence intensity measurements of the EPS showed that the presence of metal(loid)s stimulated the production of extracellular tryptophan-like and aromatic protein-like substances. Examination of fluorescence quenching and calculation of binding constants revealed that the fluorescence quenching process for Hg; arsenic (As), as arsenite; and Pb to EPS were mainly governed by static quenching which resulted in the formation of a stable non-fluorescent complexes between the EPS and metal(loid)s. Se showed no significant interaction with the EPS according to fluorescence quenching. These results provide further understanding of the interactions between metals and metalloids and EPS produced by fungi and their contribution to metal(loid) tolerance. Key points • Metal(loid)s enhanced production of tryptophan- and aromatic protein-like substances. • Non-fluorescent complexes formed between the EPS and tested metal(loid)s. • EPS complexation and binding of metal(loid)s was dependent on the tested element. • Metal(loid)-induced changes in EPS composition contributed to metal(loid) tolerance.


2014 ◽  
Vol 159 ◽  
pp. 112-117 ◽  
Author(s):  
Ling-Yun Yao ◽  
Yi-Xiang Zhu ◽  
Rui-Hua Jiao ◽  
Yan-Hua Lu ◽  
Ren-Xiang Tan

2006 ◽  
Vol 82 (1) ◽  
pp. 58-64 ◽  
Author(s):  
EM Rodríguez Porcel ◽  
JL Casas López ◽  
JA Sánchez Pérez ◽  
Y Chisti

2015 ◽  
Vol 14 (1) ◽  
Author(s):  
Yu-Kuang Wang ◽  
Zhe Chi ◽  
Hai-Xiang Zhou ◽  
Guang-Lei Liu ◽  
Zhen-Ming Chi

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