Enhanced Production of 2-Hydroxyphenazine from Glycerol by a Two-Stage Fermentation Strategy in Pseudomonas chlororaphis GP72AN

2019 ◽  
Vol 68 (2) ◽  
pp. 561-566 ◽  
Author(s):  
Sheng-Jie Yue ◽  
Peng Huang ◽  
Song Li ◽  
Malik Jan ◽  
Hong-Bo Hu ◽  
...  
2020 ◽  
Vol 310 ◽  
pp. 123427 ◽  
Author(s):  
Cong Du ◽  
Yimin Li ◽  
Han Zong ◽  
Tangguo Yuan ◽  
Wenjie Yuan ◽  
...  

2014 ◽  
Vol 152 ◽  
pp. 162-168 ◽  
Author(s):  
Yi-Xiang Zhu ◽  
Ling-Yun Yao ◽  
Rui-Hua Jiao ◽  
Yan-Hua Lu ◽  
Ren-Xiang Tan

PLoS ONE ◽  
2017 ◽  
Vol 12 (2) ◽  
pp. e0166985 ◽  
Author(s):  
Fei Ren ◽  
Long Chen ◽  
Shuangli Xiong ◽  
Qunyi Tong

2021 ◽  
Vol 7 (12) ◽  
pp. 1038
Author(s):  
Hao Ji ◽  
Ke Xu ◽  
Xiameng Dong ◽  
Da Sun ◽  
Libo Jin

Improving the comprehensive utilization of sugars in lignocellulosic biomass is a major challenge for enhancing the economic viability of lignocellulose biorefinement. A robust yeast Pichia kudriavzevii N-X showed excellent performance in ethanol production under high temperature and low pH conditions and was engineered for ᴅ-xylonate production without xylitol generation. The recombinant strain P. kudriavzevii N-X/S1 was employed for sequential production of ᴅ-xylonate and ethanol from ᴅ-xylose, feeding on ᴅ-glucose without pH control in a two-stage strategy of aerobic and shifting micro-aerobic fermentation. Acid-pretreated corncob without detoxification and filtration was used for ᴅ-xylonate production, then simultaneous saccharification and ethanol fermentation was performed with cellulase added at pH 4.0 and at 40 °C. By this strategy, 33.5 g/L ᴅ-xylonate and 20.8 g/L ethanol were produced at yields of 1.10 g/g ᴅ-xylose and 84.3% of theoretical value, respectively. We propose a promising approach for the sequential production of ᴅ-xylonate and ethanol from non-detoxified corncob using a single microorganism.


RSC Advances ◽  
2019 ◽  
Vol 9 (45) ◽  
pp. 26532-26536 ◽  
Author(s):  
Yifeng Yang ◽  
Yilin Hou ◽  
Zhaohui Chen ◽  
Huiqiu Wang ◽  
Yu Wang ◽  
...  

High-yield production of aromatics from propane with a temperature shifting, two-stage fluidized bed reactor technology.


2007 ◽  
Vol 292 (5) ◽  
pp. L1233-L1240 ◽  
Author(s):  
Navneet Kaur Dhillon ◽  
David Pinson ◽  
Sukhbir Dhillon ◽  
Ossama Tawfik ◽  
Marsha Danley ◽  
...  

Pneumonia is a major complication of human immunodeficiency virus (HIV) pathogenesis but it develops only after prolonged infection. We used the macaque model to explore a hypothesis that the disease is a two-stage process, the first stage being establishment of the viral infection in the lung and the second being amplification of virus replication by host factors induced by chemical agents or opportunistic pathogens in the lung. Bleomycin, a chemical known to induce diffuse alveolar damage and pulmonary fibrosis with accumulation of macrophages and a rich T helper type 2 (Th2) cytokine environment, was inoculated intratracheally into five of eight SHIV 89.6P-infected macaques and into one uninfected macaque. Three additional simian HIV (SHIV)-infected macaques without bleomycin treatment served as untreated virus controls. Although none of the animals became clinically ill, bleomycin induced classical host responses in the lungs of all the treated, virus-infected macaques. There was enhanced production of the chemokine, monocyte chemotactic protein-1 (MCP-1), that had previously been shown to cause enhanced replication of the virus. Four of the five treated animals developed more productive SHIV infection in the lungs compared with the infected untreated animals. Enhanced virus replication was found primarily in infiltrating macrophages. Enhanced replication of the virus in the lungs was associated with host factors induced by the drug and supported the hypothesis for a two-stage process of pulmonary pathogenesis.


2014 ◽  
Vol 159 ◽  
pp. 112-117 ◽  
Author(s):  
Ling-Yun Yao ◽  
Yi-Xiang Zhu ◽  
Rui-Hua Jiao ◽  
Yan-Hua Lu ◽  
Ren-Xiang Tan

2006 ◽  
Vol 82 (1) ◽  
pp. 58-64 ◽  
Author(s):  
EM Rodríguez Porcel ◽  
JL Casas López ◽  
JA Sánchez Pérez ◽  
Y Chisti

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