scholarly journals Preliminary investigation of brown adipose tissue assessed by PET/CT and cancer activity

2018 ◽  
Vol 48 (3) ◽  
pp. 413-419 ◽  
Author(s):  
Stijn A. Bos ◽  
Corey M. Gill ◽  
Edgar L. Martinez-Salazar ◽  
Martin Torriani ◽  
Miriam A. Bredella
Keyword(s):  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Preliminary Investigation ◽  
Brown Adipose ◽  
Pet Ct ◽  
Cancer Activity

Determinants of Physiologic 18F-FDG Uptake in Brown Adipose Tissue in Sequential PET/CT Examinations

2010 ◽  
Vol 13 (5) ◽  
pp. 1029-1035 ◽  
Author(s):  
Leonardo Pace ◽  
Emanuele Nicolai ◽  
Domenico D’Amico ◽  
Francesco Ibello ◽  
Anna Maria Della Morte ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Fdg Uptake ◽  
Brown Adipose ◽  
Pet Ct ◽  
18F Fdg

scholarly journals The prevalence and predictors of active brown adipose tissue in Chinese adults

2014 ◽  
Vol 170 (3) ◽  
pp. 359-366 ◽  
Author(s):  
Zhaoyun Zhang ◽  
Aaron M Cypess ◽  
Qing Miao ◽  
Hongying Ye ◽  
Chong Wee Liew ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Glucose Uptake ◽  
High Glucose ◽  
Healthy Individuals ◽  
Chinese Adults ◽  
Bat Activity ◽  
The Metabolic Syndrome ◽  
Brown Adipose ◽  
Pet Ct

ObjectivePrevious studies have shown that active brown adipose tissue (BAT) is present in adults and may play important roles in the regulation of energy homeostasis. However, nearly every study has been carried out in patients undergoing scanning for cancer surveillance (CS), whose metabolism and BAT activity may not reflect those of healthy individuals. The objective of this study was to investigate the prevalence and predictors of active BAT in Chinese adults, particularly in healthy individuals.DesignA total of 31 088 consecutive subjects aged ≥18 years who had undergone positron emission tomography/computed tomography (PET/CT) scanning of BAT were evaluated in this study.MethodsWe measured BAT activity via18F-fluorodeoxyglucose PET/CT in subjects who had undergone scanning for either a routine medical checkup (MC) or CS in Shanghai. Then, we investigated the predictors of active BAT, particularly in healthy individuals.ResultsIn both groups, the prevalence of BAT was higher in women than in men. Using a multivariate logistic analysis, we found age, sex, BMI, and high thyroid glucose uptake to be significant predictors of BAT activity in the MC group. Similarly, we found age, sex, and BMI to be significant predictors of BAT activity, but not thyroid high glucose uptake, in the CS group.ConclusionsIn Chinese adults, BAT activity inversely correlates with BMI and thyroid high glucose uptake, which reinforces the central role of brown fat in adult metabolism and provides clues to a potential means for treating the metabolic syndrome.

scholarly journals Assessment of the Aging of the Brown Adipose Tissue by 18F-FDG PET/CT Imaging in the Progeria Mouse Model Lmna−/−

2018 ◽  
Vol 2018 ◽  
pp. 1-9 ◽  
Author(s):  
Zhengjie Wang ◽  
Xiaolong Xu ◽  
Yi Liu ◽  
Yongheng Gao ◽  
Fei Kang ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Fdg Pet ◽  
Uncoupling Protein ◽  
Ct Imaging ◽  
Terminal Deoxynucleotidyl Transferase ◽  
Expression Levels ◽  
Brown Adipose ◽  
Pet Ct ◽  
Fdg Pet Ct

Brown adipose tissue (BAT) is an important energy metabolic organ that is highly implicated in obesity, type 2 diabetes, and atherosclerosis. Aging is one of the most important determinants of BAT activity. In this study, we used 18F-FDG PET/CT imaging to assess BAT aging in Lmna−/− mice. The maximum standardized uptake value (SUVMax) of the BAT was measured, and the target/nontarget (T/NT) values of BAT were calculated. The transcription and the protein expression levels of the uncoupling protein 1 (UCP1), beta3-adrenergic receptor (β3-AR), and the PR domain-containing 16 (PRDM16) were measured by quantitative real-time polymerase chain reaction (RT-PCR) and Western blotting or immunohistochemical analysis. Apoptosis and cell senescence rates in the BAT of WT and Lmna−/− mice were determined by terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) and by CDKN2A/p16INK4a immunohistochemical staining, respectively. At 14 weeks of age, the BAT SUVMax and the expression levels of UCP1, β3-AR, and PRDM16 in Lmna−/− mice were significantly reduced relative to WT mice. At the same time, the number of p16INK4a and TUNEL positively stained cells (%) increased in Lmna−/− mice. Collectively, our results indicate that the aging characteristics and the aging regulatory mechanism in the BAT of Lmna−/− mice can mimic the normal BAT aging process.

scholarly journals The Relationship between Brown Adipose Tissue Activity and Neoplastic Status: an 18F-FDG PET/CT Study in the Tropics

2011 ◽  
Vol 10 (1) ◽  
pp. 238 ◽  
Author(s):  
Yung-Cheng Huang ◽  
Tai-Been Chen ◽  
Chien-Chin Hsu ◽  
Shau-Hsuan Li ◽  
Pei-Wen Wang ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Fdg Pet ◽  
Brown Adipose ◽  
Pet Ct ◽  
18F Fdg ◽  
Brown Adipose Tissue Activity ◽  
Fdg Pet Ct ◽  
The Tropics ◽  
The Relationship

scholarly journals Brown Adipose Tissue Volume and Fat Content are Positively Associated with Whole-Body Adiposity in Young Men, Not in Women

2021 ◽  
Author(s):  
Guillermo Sanchez-Delgado ◽  
Borja Martinez-Tellez ◽  
Francisco M. Acosta ◽  
Samuel Virtue ◽  
Antonio Vidal-Puig ◽  
...  
Keyword(s):  
Young Adults ◽  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Fat Mass ◽  
Visceral Adipose Tissue ◽  
Whole Body ◽  
Body Adiposity ◽  
Brown Adipose ◽  
Pet Ct ◽  
Visceral Adipose

<a>Human brown adipose tissue (BAT) volume has been consistently claimed as inversely associated with whole-body adiposity. However, recent advances in the assessment of human BAT suggest that previously reported associations may have been biased. The present cross-sectional study investigates the association of BAT volume, mean radiodensity, and <sup>18</sup>F-fluordeoxyglucose (<sup>18</sup>F-FDG) uptake (assessed via a static positron emission tomography-computerized tomography (PET-CT) scan after a 2-hour personalized cold exposure) with whole-body adiposity (measured by dual-energy X-ray absorptiometry) in 126 young adults (42 men / 84 women; 25±5 kg/m<sup>2</sup>). BAT volume, but not <sup>18</sup>F-FDG uptake, was positively associated with body mass index (BMI), fat mass, and visceral adipose tissue mass in men, but not in women. These associations were independent of the date when the PET-CT was performed, insulin sensitivity and body surface area. BAT mean radiodensity, an inverse proxy of BAT fat content, was negatively associated </a>was with BMI, waist circumference, fat mass and visceral adipose tissue mas in men and with percentage fat mass in women. These results refute the widely held belief that human BAT volume is reduced in obese persons, at least in young adults, and suggest that it might even be the opposite in young men.

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