Abstract No. 474 A Pilot study of the feasibility of ultrasound-PET/CT fusion–guided supraclavicular brown adipose tissue biopsy

2019 ◽  
Vol 30 (3) ◽  
pp. S206
Author(s):  
E. Levy ◽  
S. Xu ◽  
O. Alana ◽  
C. Cheryl ◽  
J. Johnson ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Pilot Study ◽  
Brown Adipose Tissue ◽  
Tissue Biopsy ◽  
Brown Adipose ◽  
Pet Ct

scholarly journals A pilot study of FDG PET/CT detects a link between brown adipose tissue and breast cancer

BMC Cancer ◽  
2014 ◽  
Vol 14 (1) ◽  
Author(s):  
Qi Cao ◽  
Jerome Hersl ◽  
Hongloan La ◽  
Mark Smith ◽  
Jason Jenkins ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Adipose Tissue ◽  
Pilot Study ◽  
Brown Adipose Tissue ◽  
Fdg Pet ◽  
Brown Adipose ◽  
Pet Ct ◽  
Fdg Pet Ct

Determinants of Physiologic 18F-FDG Uptake in Brown Adipose Tissue in Sequential PET/CT Examinations

2010 ◽  
Vol 13 (5) ◽  
pp. 1029-1035 ◽  
Author(s):  
Leonardo Pace ◽  
Emanuele Nicolai ◽  
Domenico D’Amico ◽  
Francesco Ibello ◽  
Anna Maria Della Morte ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Fdg Uptake ◽  
Brown Adipose ◽  
Pet Ct ◽  
18F Fdg

scholarly journals The prevalence and predictors of active brown adipose tissue in Chinese adults

2014 ◽  
Vol 170 (3) ◽  
pp. 359-366 ◽  
Author(s):  
Zhaoyun Zhang ◽  
Aaron M Cypess ◽  
Qing Miao ◽  
Hongying Ye ◽  
Chong Wee Liew ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Glucose Uptake ◽  
High Glucose ◽  
Healthy Individuals ◽  
Chinese Adults ◽  
Bat Activity ◽  
The Metabolic Syndrome ◽  
Brown Adipose ◽  
Pet Ct

ObjectivePrevious studies have shown that active brown adipose tissue (BAT) is present in adults and may play important roles in the regulation of energy homeostasis. However, nearly every study has been carried out in patients undergoing scanning for cancer surveillance (CS), whose metabolism and BAT activity may not reflect those of healthy individuals. The objective of this study was to investigate the prevalence and predictors of active BAT in Chinese adults, particularly in healthy individuals.DesignA total of 31 088 consecutive subjects aged ≥18 years who had undergone positron emission tomography/computed tomography (PET/CT) scanning of BAT were evaluated in this study.MethodsWe measured BAT activity via18F-fluorodeoxyglucose PET/CT in subjects who had undergone scanning for either a routine medical checkup (MC) or CS in Shanghai. Then, we investigated the predictors of active BAT, particularly in healthy individuals.ResultsIn both groups, the prevalence of BAT was higher in women than in men. Using a multivariate logistic analysis, we found age, sex, BMI, and high thyroid glucose uptake to be significant predictors of BAT activity in the MC group. Similarly, we found age, sex, and BMI to be significant predictors of BAT activity, but not thyroid high glucose uptake, in the CS group.ConclusionsIn Chinese adults, BAT activity inversely correlates with BMI and thyroid high glucose uptake, which reinforces the central role of brown fat in adult metabolism and provides clues to a potential means for treating the metabolic syndrome.

scholarly journals Assessment of the Aging of the Brown Adipose Tissue by 18F-FDG PET/CT Imaging in the Progeria Mouse Model Lmna−/−

2018 ◽  
Vol 2018 ◽  
pp. 1-9 ◽  
Author(s):  
Zhengjie Wang ◽  
Xiaolong Xu ◽  
Yi Liu ◽  
Yongheng Gao ◽  
Fei Kang ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Fdg Pet ◽  
Uncoupling Protein ◽  
Ct Imaging ◽  
Terminal Deoxynucleotidyl Transferase ◽  
Expression Levels ◽  
Brown Adipose ◽  
Pet Ct ◽  
Fdg Pet Ct

Brown adipose tissue (BAT) is an important energy metabolic organ that is highly implicated in obesity, type 2 diabetes, and atherosclerosis. Aging is one of the most important determinants of BAT activity. In this study, we used 18F-FDG PET/CT imaging to assess BAT aging in Lmna−/− mice. The maximum standardized uptake value (SUVMax) of the BAT was measured, and the target/nontarget (T/NT) values of BAT were calculated. The transcription and the protein expression levels of the uncoupling protein 1 (UCP1), beta3-adrenergic receptor (β3-AR), and the PR domain-containing 16 (PRDM16) were measured by quantitative real-time polymerase chain reaction (RT-PCR) and Western blotting or immunohistochemical analysis. Apoptosis and cell senescence rates in the BAT of WT and Lmna−/− mice were determined by terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) and by CDKN2A/p16INK4a immunohistochemical staining, respectively. At 14 weeks of age, the BAT SUVMax and the expression levels of UCP1, β3-AR, and PRDM16 in Lmna−/− mice were significantly reduced relative to WT mice. At the same time, the number of p16INK4a and TUNEL positively stained cells (%) increased in Lmna−/− mice. Collectively, our results indicate that the aging characteristics and the aging regulatory mechanism in the BAT of Lmna−/− mice can mimic the normal BAT aging process.

scholarly journals Preliminary investigation of brown adipose tissue assessed by PET/CT and cancer activity

2018 ◽  
Vol 48 (3) ◽  
pp. 413-419 ◽  
Author(s):  
Stijn A. Bos ◽  
Corey M. Gill ◽  
Edgar L. Martinez-Salazar ◽  
Martin Torriani ◽  
Miriam A. Bredella
Keyword(s):  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Preliminary Investigation ◽  
Brown Adipose ◽  
Pet Ct ◽  
Cancer Activity

scholarly journals The Relationship between Brown Adipose Tissue Activity and Neoplastic Status: an 18F-FDG PET/CT Study in the Tropics

2011 ◽  
Vol 10 (1) ◽  
pp. 238 ◽  
Author(s):  
Yung-Cheng Huang ◽  
Tai-Been Chen ◽  
Chien-Chin Hsu ◽  
Shau-Hsuan Li ◽  
Pei-Wen Wang ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Fdg Pet ◽  
Brown Adipose ◽  
Pet Ct ◽  
18F Fdg ◽  
Brown Adipose Tissue Activity ◽  
Fdg Pet Ct ◽  
The Tropics ◽  
The Relationship

scholarly journals Multimodal Imaging for the Detection of Brown Adipose Tissue Activation in Women: A Pilot Study Using NIRS and Infrared Thermography

2017 ◽  
Vol 2017 ◽  
pp. 1-6 ◽  
Author(s):  
Valentina Hartwig ◽  
Letizia Guiducci ◽  
Martina Marinelli ◽  
Laura Pistoia ◽  
Tommaso Minutoli Tegrimi ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Pilot Study ◽  
Brown Adipose Tissue ◽  
Infrared Thermography ◽  
Pharmacological Intervention ◽  
Oral Glucose ◽  
Cold Stimulation ◽  
Standard Clinical Practice ◽  
Obesity And Diabetes ◽  
Brown Adipose

Purpose. A clear link between obesity and brown adipose tissue (BAT) dysfunction has been recently demonstrated. The purpose of this pilot study is to determine if near-infrared spectroscopy (NIRS) 2D imaging together with infrared thermography (IRT) is capable of identifying thermal and vascular response in the supraclavicular (SCV) areas after the ingestion of an oral glucose load as a thermogenic stimulation. Method. We studied two groups of women (obese versus lean) for discerning their different responses. NIRS and IRT images were acquired on the neck in the left SCV region during a 3 h oral glucose tolerance test (OGTT) and immediately after a cold stimulation. Results. We detected a significant thermal response of BAT in SCV fossa in both groups. Both during OGTT and after cold stimulation, skin temperature was persistently higher in lean versus obese. This response was not coupled with changes in oxygen saturation of subcutaneous tissue in that area. Discussion and Conclusion. The results show that NIRS/IRT may be a novel, noninvasive, radiation-free, easy to use, and low-cost method for monitoring, during the standard clinical practice, the diet and pharmacological intervention which aims to stimulate BAT as a potential therapeutic target against obesity and diabetes.

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